{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:58:02Z","timestamp":1790812682391,"version":"4.1.0"},"reference-count":21,"publisher":"Scientific Scholar","content-domain":{"domain":["indianjnephrol.org"],"crossmark-restriction":true},"short-container-title":["Indian J Nephrol"],"abstract":"\n Background<\/jats:title>\n Carbapenem-resistant urinary tract infections (CR-UTIs) are a major global health threat. Many factors contribute to the increasing incidence of CR-UTI. Owing to the limited availability of treatment options, CR-UTIs are highly challenging to treat.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n \n This was a single-center, hospital-based, observational, retrospective cohort study. We investigated the treatment results, microbiological profiles, and clinical manifestations of CR-UTI at our institution between January 2017 and December 2021. All patients exhibiting clinical signs and symptoms of urinary tract infection (UTI) and a urine culture that showed growth of a single organism greater than 10\n 5<\/jats:sup>\n colony-forming units\/ml were included. All patients were considered for a 1-year follow-up.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n From January 2017 to December 2022, 3016 (31%) CR-UTI episodes were noted. Approximately, 75% of CR-UTI episodes were caused by the most prevalent urinary pathogens,\n Escherichia coli<\/jats:italic>\n and\n Klebsiella pneumoniae<\/jats:italic>\n . Within 28 days, 308 patients (12.59%) died. Enterobacteriaceae treated for a minimum of 7\u201310 days showed a greater response to Aminoglycosides, Fosfomycin, Ceftizoxime, Colistin with Carbapenem, Tigecycline with Carbapenem, and Ceftazidime\/avibactam. Within a year, 994 CR-UTI episodes were identified in patients who were available for follow-up; and 38% of these episodes were the result of relapse. Three-quarters of the remaining incidents were recurrent, accounting for a higher mortality rate (14.2%) within a year.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Despite effective antibiotic treatment, CR-UTIs are associated with early relapse and recurrence. Newer effective treatment and preventive strategies are required to address this pandemic.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/ijn_530_23","type":"journal-article","created":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T08:57:58Z","timestamp":1721033878000},"page":"53-58","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical, Microbiological Profile, and Treatment Outcomes of Carbapenem-Resistant Urinary Tract Infections in a Tertiary Care Hospital"],"prefix":"10.25259","volume":"35","author":[{"given":"Mahesh","family":"Eshwarappa","sequence":"first","affiliation":[{"name":"Department of Nephrology, M S Ramaiah Medical College, Bangalore, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul Sai","family":"Gangula","sequence":"additional","affiliation":[{"name":"Department of Nephrology, M S Ramaiah Medical College, Bangalore, 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