{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:22:59Z","timestamp":1784956979364,"version":"3.55.0"},"reference-count":27,"publisher":"Scientific Scholar","content-domain":{"domain":["indianjnephrol.org"],"crossmark-restriction":true},"short-container-title":["Indian J Nephrol"],"abstract":"<jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Nephrotic syndrome (NS) is relapsing\u2013remitting illness affecting children and characterized by proteinuria, edema, and hypoalbuminemia. The disease involves the significant formative years of a child\u2019s life and profoundly impacts their physical and psychosocial well-being. There is a scarcity of literature exploring the quality of life (QoL) of children with NS and the factors influencing them. The study aimed to discuss the QoL of children with NS and the factors influencing it.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Materials and Methods<\/jats:title>\n<jats:p>A systematic search of electronic databases, including PubMed, Google Scholar, and Embase, was carried out from 2004 to August 2023. Nineteen original articles in English language that focused on evaluating the QoL of children with NS were included. Articles in languages other than English, letters, and editorial reviews, studies involving populations other than children, were excluded.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Children with NS tend to have a better QoL as compared to those with other chronic diseases (p = &lt;0.001), but it remains lower than that of healthy children (p&lt;0.05). School functioning was the most affected domain. Recurrent relapses, prolonged illness, high steroid dosages, and multiple medications are significant contributors to impaired QoL. Children with steroid-resistant nephrotic syndrome (SRNS) had poorer QoL among the clinical subtypes.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Children with NS face various challenges that impact their QoL. Comprehensive care strategies to enhance QoL are the need of the hour.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijn_5_2024","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T05:27:03Z","timestamp":1724304423000},"page":"234-242","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Quality of Life of Children with Idiopathic Nephrotic Syndrome"],"prefix":"10.25259","volume":"35","author":[{"given":"Jyoti","family":"Shukla","sequence":"first","affiliation":[{"name":"Chitkara School of Health Sciences, Chitkara University, Punjab, India"},{"name":"Kalawati Saran Children Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Gupta","sequence":"additional","affiliation":[{"name":"Chitkara School of Health Sciences, Chitkara University, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raminder","family":"Kalra","sequence":"additional","affiliation":[{"name":"Holy Family College of Nursing, Delhi University, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"10.25259\/IJN_5_2024\/ref-1","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(03)14184-0","article-title":"Nephrotic syndrome in childhood","volume":"362","author":"Eddy","year":"2003","journal-title":"Lancet"},{"key":"10.25259\/IJN_5_2024\/ref-2","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1542\/pir.30-3-94","article-title":"The nephrotic syndrome","volume":"30","author":"Gordillo","year":"2009","journal-title":"Pediatr Rev"},{"key":"10.25259\/IJN_5_2024\/ref-3","first-page":"419","article-title":"Steroid sensitive nephrotic syndrome","volume-title":"Pediatric kidney disease 2017","author":"Hodson","year":"2017"},{"key":"10.25259\/IJN_5_2024\/ref-4","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1007\/s004670100021","article-title":"Time trends and ethnic patterns of childhood nephrotic syndrome in Yorkshire, UK","volume":"16","author":"McKinney","year":"2001","journal-title":"Pediatr Nephrol"},{"key":"10.25259\/IJN_5_2024\/ref-5","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13052-015-0123-9","article-title":"Steroid-sensitive nephrotic syndrome in children: Triggers of relapse and evolving hypotheses on pathogenesis","volume":"41","author":"Uwaezuoke","year":"2015","journal-title":"Ital J Pediatr"},{"key":"10.25259\/IJN_5_2024\/ref-6","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1007\/s00467-015-3074-x","article-title":"The impact of disease duration on quality of life in children with nephrotic syndrome: A Midwest pediatric nephrology consortium study","volume":"30","author":"Selewski","year":"2015","journal-title":"Pediatr Nephrol"},{"key":"10.25259\/IJN_5_2024\/ref-7","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1542\/peds.2011-2111","article-title":"Pediatric self-management: A framework for research, practice, and policy","volume":"129","author":"Modi","year":"2012","journal-title":"Pediatrics"},{"key":"10.25259\/IJN_5_2024\/ref-8","first-page":"182","article-title":"Exploring conceptual context for resilience assessment scale for children with renal diseases","volume":"12","author":"Kaur","year":"2020","journal-title":"Int J Nurs Educ"},{"key":"10.25259\/IJN_5_2024\/ref-9","doi-asserted-by":"publisher","first-page":"4605","DOI":"10.1007\/s00431-023-05135-5","article-title":"Health-related quality of life of children with first onset steroid-sensitive nephrotic syndrome","volume":"182","author":"Veltkamp","year":"2023","journal-title":"Eur J Pediatr"},{"key":"10.25259\/IJN_5_2024\/ref-10","first-page":"703","article-title":"Health-related quality of life in children with nephrotic syndrome in Bangladesh","volume":"25","author":"Rahman","year":"2016","journal-title":"Mymensingh Med J"},{"key":"10.25259\/IJN_5_2024\/ref-11","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1007\/s11136-020-02438-0","article-title":"Health-related quality of life in egyptian children with nephrotic syndrome","volume":"29","author":"Eid","year":"2020","journal-title":"Qual Life Res"},{"key":"10.25259\/IJN_5_2024\/ref-12","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ekir.2019.05.358","article-title":"Sat-316 health related quality of life of children with nephrotic syndrome in Lagos Nigeria","volume":"4","author":"Solarin","year":"2019","journal-title":"Kidney Int Reports"},{"key":"10.25259\/IJN_5_2024\/ref-13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2147\/PHMT.S437364","article-title":"The clinical parameters affecting the health-related quality of life of children with nephrotic syndrome","volume":"1","author":"Rita Mbanefo","year":"2018","journal-title":"Arch Nephrol"},{"key":"10.25259\/IJN_5_2024\/ref-14","doi-asserted-by":"crossref","first-page":"401","DOI":"10.15562\/ism.v14i1.1658","article-title":"The quality of life in children with nephrotic syndrome at prof I.G.N.G Ngoerah hospital, denpasar, bali","volume":"14","author":"Kresnandari","year":"2023","journal-title":"Intisari Sains Medis"},{"key":"10.25259\/IJN_5_2024\/ref-15","doi-asserted-by":"crossref","first-page":"138","DOI":"10.36348\/gajms.2023.v05i03.003","article-title":"Quality of life in children with minimal change nephrotic syndrome","volume":"5","author":"Parveen","year":"2023","journal-title":"Glob Acad J Med Sci"},{"key":"10.25259\/IJN_5_2024\/ref-16","doi-asserted-by":"publisher","first-page":"154","DOI":"10.11604\/pamj.2022.43.154.34980","article-title":"Assessment of health-related quality of life in sudanese children with nephrotic syndrome: A questionnaire-based study","volume":"43","author":"Allam","year":"2022","journal-title":"Pan Afr Med J"},{"key":"10.25259\/IJN_5_2024\/ref-17","doi-asserted-by":"crossref","first-page":"118426","DOI":"10.5812\/ijp-118426","article-title":"Heath-related quality of life in iranian children with nephrotic syndrome","volume":"32","author":"Abbasi","year":"2022","journal-title":"Iran J Pediatr"},{"key":"10.25259\/IJN_5_2024\/ref-18","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1007\/s10157-022-02186-0","article-title":"Quality of life in children with nephrotic syndrome: A cross-sectional study using Hindi version of PedsQL 4.0 generic core scales","volume":"26","author":"Mazahir","year":"2022","journal-title":"Clin Exp Nephrol"},{"key":"10.25259\/IJN_5_2024\/ref-19","first-page":"306","article-title":"Psychosocial functioning and health-related quality of life in children with nephrotic syndrome: Preliminary findings","volume":"18","author":"Aier","year":"2022"},{"key":"10.25259\/IJN_5_2024\/ref-20","doi-asserted-by":"publisher","first-page":"745444","DOI":"10.3389\/fped.2021.745444","article-title":"Evaluating the quality of life of 231 children with primary nephrotic syndrome and assessing parental awareness of the disease","volume":"9","author":"Li","year":"2021","journal-title":"Front Pediatr"},{"key":"10.25259\/IJN_5_2024\/ref-21","doi-asserted-by":"publisher","first-page":"593","DOI":"10.4103\/1319-2442.206452","article-title":"Assessment of quality of life in children with nephrotic syndrome at a teaching hospital in South India","volume":"28","author":"Agrawal","year":"2017","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"10.25259\/IJN_5_2024\/ref-22","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1007\/s12098-020-03494-7","article-title":"Behavioral problems, quality of life and caregiver burden in children with idiopathic nephrotic syndrome: Improving outcomes by pragmatic interventions in a resource-poor setting","volume":"88","author":"Menon","year":"2021","journal-title":"Indian J Pediatr"},{"key":"10.25259\/IJN_5_2024\/ref-23","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1111\/apa.14912","article-title":"Quality of life in children with severe forms of idiopathic nephrotic syndrome in stable remission\u2014A cross-sectional study","volume":"108","author":"Roussel","year":"2019","journal-title":"Acta Paediatr Int J Paediatr"},{"key":"10.25259\/IJN_5_2024\/ref-24","doi-asserted-by":"publisher","first-page":"3193","DOI":"10.1007\/s00467-022-05809-6","article-title":"Family functioning and quality of life among children with nephrotic syndrome during the first pandemic wave","volume":"38","author":"Aman","year":"2023","journal-title":"Pediatr Nephrol"},{"key":"10.25259\/IJN_5_2024\/ref-25","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00467-020-04684-3","article-title":"Impact of steroids and steroid-sparing agents on quality of life in children with nephrotic syndrome","volume":"36","author":"Khullar","year":"2021","journal-title":"Pediatr Nephrol."},{"key":"10.25259\/IJN_5_2024\/ref-26","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.jpeds.2004.08.022","article-title":"Health-related quality of life and psychosocial adjustment in steroid-sensitive nephrotic syndrome","volume":"145","author":"R\u00fcth","year":"2004","journal-title":"J Pediatr"},{"key":"10.25259\/IJN_5_2024\/ref-27","first-page":"2281","article-title":"A Pre-experimental study to assess the effectiveness of structured teaching programme on knowledge regarding dietary modification among chronic kidney disease patients undergoing haemodialysis IJSRR","volume":"8","author":"Singh","year":"2019"}],"container-title":["Indian Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/indianjnephrol.org\/quality-of-life-of-children-with-idiopathic-nephrotic-syndrome-a-review\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/indianjnephrol.org\/quality-of-life-of-children-with-idiopathic-nephrotic-syndrome-a-review\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T10:34:31Z","timestamp":1740566071000},"score":1,"resource":{"primary":{"URL":"https:\/\/indianjnephrol.org\/quality-of-life-of-children-with-idiopathic-nephrotic-syndrome-a-review\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":27,"alternative-id":["10.25259\/IJN_5_2024"],"URL":"https:\/\/doi.org\/10.25259\/ijn_5_2024","relation":{},"ISSN":["1998-3662","0971-4065"],"issn-type":[{"value":"1998-3662","type":"electronic"},{"value":"0971-4065","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,22]]},"article-number":"234"}}