{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T20:34:25Z","timestamp":1770064465597,"version":"3.49.0"},"reference-count":17,"publisher":"Scientific Scholar","content-domain":{"domain":["jpalliativecare.com"],"crossmark-restriction":true},"short-container-title":["IJPC"],"abstract":"\nObjectives:<\/jats:title>\nMorphine is the cornerstone of pain management in a palliative care setting. Nausea with or without vomiting usually occurs when patients are initiated on morphine for the 1st<\/jats:sup> time or when the dose is substantially increased.<\/jats:p>\n<\/jats:sec>\n\nMaterials and Methods:<\/jats:title>\nA total of 90 patients fulfilling the inclusion criteria were randomly allocated into two groups of 45 each. Group M received a tablet of metoclopramide 10 mg orally 3 times a day; Group H received a tablet of haloperidol (2.5 mg) orally at night. All the patients were provided NCI CTCAE V4.3 NAUSEA AND VOMITING SCALE and asked to mark their response from day 1 to day 7. At the follow-up visit on the 7th<\/jats:sup> day, the form was collected, and data were analysed.<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:title>\nIn Group M and Group H, the mean nausea score was between 1 and 2 and the difference was statistically insignificant. In Group M, the maximum vomiting score was 1.28 on day 5, while in Group H, the maximum score was 2 on day 5. The difference between the two groups was statistically significant.<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nMetoclopramide and haloperidol are equally efficacious in preventing nausea, but metoclopramide was found to be more effective with lesser side effects than haloperidol for morphine-induced vomiting in cancer patients when used prophylactically.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijpc_141_2024","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T06:35:36Z","timestamp":1727764536000},"page":"375-379","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Efficacy and Safety of Prophylactic Use of Metoclopramide and Haloperidol on Morphine-induced Nausea and Vomiting in Cancer Patients: A Comparative, Randomised, Prospective Study"],"prefix":"10.25259","volume":"30","author":[{"given":"Yogendra","family":"Singhal","sequence":"first","affiliation":[{"name":"Department of Palliative Medicine, Sawai Man Singh Medical College, Jaipur, Rajasthan, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surendra Kumar","family":"Pingoliya","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Sawai Man Singh Medical College, Jaipur, Rajasthan, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sreeharsh","family":"Saji","sequence":"additional","affiliation":[{"name":"Department of Palliative Medicine, Sawai Man Singh Medical College, Jaipur, Rajasthan, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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