{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:03:48Z","timestamp":1789009428022,"version":"build-2803163510"},"reference-count":16,"publisher":"Scientific Scholar","content-domain":{"domain":["jpalliativecare.com"],"crossmark-restriction":true},"short-container-title":["IJPC"],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Objectives:<\/jats:title>\n<jats:p>Patients with advanced cancer with incurable diseases are generally cared for by their families in India. There is a lack of data on the perceived caregiver burden, quality of life (QOL) of patients and caregivers in India, especially among cancer patients not on any oncologic management.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Material and Methods:<\/jats:title>\n<jats:p>We conducted a cross-sectional study among 220 patients of advanced cancer on best supportive care and their respective 220 family caregivers. Our primary objective was to identify a correlation between caregiver burden and QOL. After taking informed consent from both patients and caregivers, we assessed the QOL of the patient using the European Organization for the Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire Core 15 Palliative Care (QLQ C15PAL) questionnaire from the patient, assessing the Caregiver Burden using Zarit Burden Interview, assessing the QOL of the caregiver using the WHO QOL BREF Questionnaire, in a single session during their routine follow-up in the Palliative Care Clinic of our institution.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results:<\/jats:title>\n<jats:p>We noticed a statistically significant negative (Spearman) correlation between the Caregiver Burden as assessed by Zarit Burden Interview (ZBI) and the psychological (r = \u22120.302, <jats:italic>P<\/jats:italic> &lt; 0.01), social (r= \u22120.498, <jats:italic>P<\/jats:italic> &lt; 0.01) and environmental (r = \u22120.396, <jats:italic>P<\/jats:italic> &lt; 0.01) domains of the WHO QOL BREF Questionnaire. Caregiving Burden as assessed ZBI total score was noted to have a statistically significant negative correlation with physical functioning (r = \u22120.37, <jats:italic>P<\/jats:italic> &lt; 0.01), emotional functioning (r = \u22120.435, <jats:italic>P<\/jats:italic> &lt; 0.01) and global QOL scores (r = \u22120.499, <jats:italic>P<\/jats:italic> &lt; 0.01) assessed from the patient using the EORTC QLQ C15 PAL questionnaire. It also had a statistically significant small positive correlation with EORTC QLQ C15 PAL symptom scores, such as dyspnoea, insomnia, constipation, nausea, fatigue and pain. The median caregiver burden score was 39, showing higher burden as compared to previous studies. Caregivers who were spouses of the patient, illiterate, homemakers, with low-income families reported higher burden.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>A high perceived caregiving burden is associated with impaired QOL in family caregivers of advanced cancer patients on best supportive care. Multiple patient related factors and demographic factors tend to affect burden of the caregiver.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijpc_175_2022","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T12:24:34Z","timestamp":1666009474000},"page":"89-93","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Correlation between Quality of Life and Burden in Caregivers of Advanced Stage Cancer Patients on Best Supportive Care"],"prefix":"10.25259","volume":"29","author":[{"given":"Manavalan","family":"Manivannan","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunaseelan","family":"Karunanithi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (Regional Cancer Center), Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subitha","family":"Lakshminarayanan","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"10.25259\/IJPC_175_2022\/ref-1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.25259\/IJPC_175_2022\/ref-2","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1200\/GO.20.00122","article-title":"Cancer statistics, 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