{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T07:41:05Z","timestamp":1679298065531},"reference-count":35,"publisher":"Scientific Scholar","content-domain":{"domain":["jpalliativecare.com"],"crossmark-restriction":true},"short-container-title":["IJPC"],"abstract":"\nObjectives:<\/jats:title>\nAn increasing number of elderly subjects with cancer were admitted to the palliative care unit and they have suffered both distressing symptoms and cognitive impairment. We aim to identify the prevalence of cognitive impairment among elderly cancer patients receiving in-patient palliative care and to examine any difference between patients with cognitive impairment on self-reported symptoms.<\/jats:p>\n<\/jats:sec>\n\nMaterials and Methods:<\/jats:title>\nSubjects\u2019 age \u226565 admitted to a palliative care unit from 01 September 2015 to 31 August 2020 was included in the study. Exclusion criteria were those with an impaired conscious state, severe cognitive impairment, or language problems that were non-communicable. Variables collected included baseline demographics, cancer diagnosis, cancer stage, mobility state using the modified Barthel index (mBI), and performance status as measured by the palliative performance scale. Cognitive impairment was defined by abbreviated mental test \u22646. Self-reported symptoms scales were measured by the Chinese version of MD Anderson Symptom Inventory and EORTC QLQ C-30 (European Organisation for Research and Treatment of Cancer, Quality of Life Core Questionnaire 30).<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:title>\nNine hundred and ninety-one subjects with 1174 admissions were retrieved. Eight hundred and seventy-three admission episodes were included in this study. Three hundred and eight (35%) have cognitive impairment. Cognitively impaired subjects were older, showed worse physical function and performance status, and more often residing in old age homes. Independent predictors of cognitive impairment were age (OR 1.09), mBI (OR 0.96), chair\/bed bound state (OR 1.79), and presence of brain metastasis (OR 2.63). They reported lower scores in pain (P<\/jats:italic> < 0.001), distress (P<\/jats:italic> < 0.001), sleep disturbance (P<\/jats:italic> < 0.001) and nausea and vomiting (P<\/jats:italic> = 0.012) in the self-reported symptoms scale.<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nElderly cancer patients with cognitive impairment were older with poorer performance status. They have reported a lower level of pain, distress, and sleep disturbance. Clinicians should be alerted to this phenomenon to tackle the unmet concomitant symptoms.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijpc_18_2021","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T05:38:55Z","timestamp":1642657135000},"page":"167-173","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Do Cognitively Impaired Elderly Patients with Cancer Respond Differently on Self-reported Symptom Scores? A 5-Year Retrospective Analysis"],"prefix":"10.25259","volume":"28","author":[{"given":"Doris Ka Ying","family":"Miu","sequence":"first","affiliation":[{"name":"Department of Rehabilitation and Extended Care, Wong Tai Sin Hospital, Hong Kong,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai Yin","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Extended Care, Wong Tai Sin Hospital, Hong Kong,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung On","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation and Extended Care, Wong Tai Sin Hospital, Hong Kong,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"10.25259\/IJPC_18_2021\/ref-1","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.jgo.2018.02.010","article-title":"Neurocognitive deficits in older patients with cancer","volume":"9","author":"Edwards","year":"2018","journal-title":"J Geriatr Oncol"},{"key":"10.25259\/IJPC_18_2021\/ref-2","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1111\/jgs.14363","article-title":"Aggressiveness of end-of-life care for hospitalized individuals with cancer with and without dementia: A nationwide matched-cohort study in France","volume":"64","author":"Morin","year":"2016","journal-title":"J Am Geriatr Soc"},{"key":"10.25259\/IJPC_18_2021\/ref-3","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1016\/j.jpainsymman.2018.02.012","article-title":"Cognitive impairment and pain among nursing home residents with cancer","volume":"55","author":"Dube","year":"2018","journal-title":"J Pain Symptom Manage"},{"key":"10.25259\/IJPC_18_2021\/ref-4","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1053\/j.seminoncol.2011.03.014","article-title":"An update on cancer and chemotherapy related cognitive dysfunction: Current status","volume":"38","author":"Janelsians","year":"2011","journal-title":"Semin Oncol"},{"key":"10.25259\/IJPC_18_2021\/ref-5","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/j.jagp.2017.04.001","article-title":"Cognitive effects of chemotherapy and cancer-related treatments in older adults","volume":"25","author":"Vega","year":"2017","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.25259\/IJPC_18_2021\/ref-6","doi-asserted-by":"publisher","first-page":"1836","DOI":"10.1002\/cncr.10389","article-title":"The panorama of opioid-related cognitive dysfunction in patients with cancer: A critical literature appraisal","volume":"94","author":"Lawlor","year":"2002","journal-title":"Cancer"},{"key":"10.25259\/IJPC_18_2021\/ref-7","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3109\/09540261.2013.864260","article-title":"Prevalence, mechanisms and management of cancer-related cognitive impairment","volume":"26","author":"Janelsins","year":"2014","journal-title":"Int Rev Psychiatry"},{"key":"10.25259\/IJPC_18_2021\/ref-8","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1177\/0269216312457214","article-title":"Delirium prevalence, incidence and implications for screening in specialist palliative care inpatients settings: A systematic review","volume":"27","author":"Hosie","year":"2013","journal-title":"Palliat Med"},{"key":"10.25259\/IJPC_18_2021\/ref-9","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1200\/JCO.2010.32.6884","article-title":"Prevalence and predictors of cognitive dysfunction in opioid treated cancer patients: A multi-national study","volume":"29","author":"Kurita","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.25259\/IJPC_18_2021\/ref-10","doi-asserted-by":"publisher","first-page":"63596","DOI":"10.18632\/oncotarget.18867","article-title":"Do cancer patients with dementia receive less aggressive treatment in end-of-life care? A nationwide population-based cohort study","volume":"8","author":"Huang","year":"2017","journal-title":"Oncotarget"},{"key":"10.25259\/IJPC_18_2021\/ref-11","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s00520-016-3485-7","article-title":"Identification of the predictors of cognitive impairment in patients with cancer in palliative care: A prospective longitudinal analysis","volume":"25","author":"Kurita","year":"2017","journal-title":"Support Care Cancer"},{"key":"10.25259\/IJPC_18_2021\/ref-12","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1177\/082585979601200102","article-title":"Palliative performance scale (PPS): A new tool","volume":"12","author":"Anderson","year":"1996","journal-title":"J Palliat Care"},{"key":"10.25259\/IJPC_18_2021\/ref-13","first-page":"207","article-title":"Validation of the abbreviated mental test (Hong Kong version) in the elderly medical patients","volume":"1","author":"Chu","year":"1995","journal-title":"HKMJ"},{"key":"10.25259\/IJPC_18_2021\/ref-14","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/pon.727","article-title":"Quality of life of breast cancer patients in Taiwan: Validation of the Taiwan Chinese version of the EORTC QLQ-C30 and EORTC QLQ-BR23","volume":"12","author":"Chie","year":"2013","journal-title":"Psychooncology"},{"key":"10.25259\/IJPC_18_2021\/ref-15","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1002\/cncr.20448","article-title":"Chinese version of the MD Anderson symptom inventory","volume":"101","author":"Wang","year":"2004","journal-title":"Cancer"},{"key":"10.25259\/IJPC_18_2021\/ref-16","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1089\/jpm.1998.1.177","article-title":"Delirium, confusion and agitation at the end of life","volume":"1","author":"Shuster","year":"1998","journal-title":"J Palliat Med"},{"key":"10.25259\/IJPC_18_2021\/ref-17","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1097\/00002093-200110000-00005","article-title":"Scales for evaluation of end-of-life care in dementia","volume":"15","author":"Volicer","year":"2001","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.25259\/IJPC_18_2021\/ref-18","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1093\/gerona\/60.4.524","article-title":"Feasibility and reliability of four pain assessment scales and correlation with an observational rating scale in hospitalized elderly dementia patients","volume":"60","author":"Pantex","year":"2005","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.25259\/IJPC_18_2021\/ref-19","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.iccn.2010.08.007","article-title":"Facial expression and pain in the critically ill noncommunicative patient: State of science review","volume":"26","author":"Arif-Rahu","year":"2010","journal-title":"Intensive Crit Care Nurs"},{"key":"10.25259\/IJPC_18_2021\/ref-20","doi-asserted-by":"publisher","first-page":"E13","DOI":"10.1097\/NCC.0000000000000478","article-title":"Comorbid dementia and cancer in residents of nursing homes: Secondary analyses of a cross-sectional study","volume":"41","author":"Blytt","year":"2018","journal-title":"Cancer Nurs"},{"key":"10.25259\/IJPC_18_2021\/ref-21","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1111\/ggi.12049","article-title":"Pain and hospice care in nursing home residents with dementia and terminal cancer","volume":"13","author":"Monroe","year":"2013","journal-title":"Geriatr Gerontol Int"},{"key":"10.25259\/IJPC_18_2021\/ref-22","doi-asserted-by":"publisher","first-page":"c1345","DOI":"10.1136\/bmj.c1345","article-title":"The impact of advance care planning on end of life care in elderly patients: Randomized controlled trial","volume":"340","author":"Detering","year":"2010","journal-title":"BMJ"},{"key":"10.25259\/IJPC_18_2021\/ref-23","article-title":"End of Life: Helping with Comfort and Care","author":"Ageing","year":"2016"},{"key":"10.25259\/IJPC_18_2021\/ref-24","doi-asserted-by":"publisher","first-page":"e020250","DOI":"10.1136\/bmjopen-2017-020250","article-title":"Cancer-related information needs and treatment decision making experiences of people with dementia in England: A multiple perspective qualitative study","volume":"8","author":"McWillian","year":"2018","journal-title":"BMJ Open"},{"key":"10.25259\/IJPC_18_2021\/ref-25","doi-asserted-by":"publisher","first-page":"e0159056","DOI":"10.1371\/journal.pone.0159056","article-title":"Sampson EL","volume":"11","author":"Dening","year":"2016","journal-title":"Advance care planning in dementia: Do family carers know the treatment preferences of people with early dementia? PLoS One"},{"key":"10.25259\/IJPC_18_2021\/ref-26","doi-asserted-by":"publisher","first-page":"e018977","DOI":"10.1136\/bmjopen-2017-018977","article-title":"Shared decision making for people living with dementia in extended care settings: A systematic review","volume":"8","author":"Daly","year":"2018","journal-title":"BMJ Open"},{"key":"10.25259\/IJPC_18_2021\/ref-27","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1097\/SPC.0000000000000054","article-title":"Cognition and pain","volume":"8","author":"Moriarty","year":"2014","journal-title":"Curr Opin Support Palliat Care"},{"key":"10.25259\/IJPC_18_2021\/ref-28","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.jpainsymman.2015.07.013","article-title":"Symptoms clusters in advanced cancer patients: An empirical comparison of statistical methods and the impact on quality of life","volume":"51","author":"Dong","year":"2016","journal-title":"J Pain Symptom Manage"},{"key":"10.25259\/IJPC_18_2021\/ref-29","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0304-3959(00)00248-7","article-title":"Neuropsychological performance in cancer patients: The role of oral opioids, pan and performance status","volume":"86","author":"Sjogren","year":"2000","journal-title":"Pain"},{"key":"10.25259\/IJPC_18_2021\/ref-30","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1177\/0269216319839024","article-title":"The trajectory of functional decline over the last 4 months of life in a palliative care population: A prospective consecutive cohort study","volume":"33","author":"Morgan","year":"2019","journal-title":"Palliat Med"},{"key":"10.25259\/IJPC_18_2021\/ref-31","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.1111\/jgs.16458","article-title":"Characteristics of people with dementia vs other conditions on admission to inpatient palliative care","volume":"68","author":"Ding","year":"2020","journal-title":"J Am Geriatr Soc"},{"key":"10.25259\/IJPC_18_2021\/ref-32","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1212\/01.WNL.0000149523.35039.4C","article-title":"Effect of corticosteroids in short-term and long-term memory","volume":"64","author":"Brunner","year":"2005","journal-title":"Neurology"},{"key":"10.25259\/IJPC_18_2021\/ref-33","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1017\/S1041610213000823","article-title":"Assessing quality of life of nursing home residents with dementia: Feasibility and limitations in patients with severe cognitive impairment","volume":"25","author":"Crespe","year":"2013","journal-title":"Int Psychogeriatr"},{"key":"10.25259\/IJPC_18_2021\/ref-34","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3233\/JAD-160538","article-title":"How different are quality of life ratings for people with dementia reported by their family caregivers from those reported by the patients themselves?","volume":"55","author":"Jacob","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.25259\/IJPC_18_2021\/ref-35","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.pmn.2014.12.002","article-title":"Pain assessment using self-reported, nurse-reported and observational pain assessment tools among older individual with cognitive impairment","volume":"16","author":"Ngu","year":"2015","journal-title":"Pain Manag Nurs"}],"container-title":["Indian Journal of Palliative Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jpalliativecare.com\/do-cognitively-impaired-elderly-patients-with-cancer-respond-differently-on-self-reported-symptom-scores-a-5-year-retrospective-analysis\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpalliativecare.com\/do-cognitively-impaired-elderly-patients-with-cancer-respond-differently-on-self-reported-symptom-scores-a-5-year-retrospective-analysis\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T07:23:47Z","timestamp":1679297027000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpalliativecare.com\/do-cognitively-impaired-elderly-patients-with-cancer-respond-differently-on-self-reported-symptom-scores-a-5-year-retrospective-analysis\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,20]]},"references-count":35,"alternative-id":["10.25259\/IJPC_18_2021"],"URL":"https:\/\/doi.org\/10.25259\/ijpc_18_2021","relation":{},"ISSN":["1998-3735","0973-1075"],"issn-type":[{"value":"1998-3735","type":"electronic"},{"value":"0973-1075","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1,20]]},"article-number":"167"}}