{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:16:22Z","timestamp":1778652982506,"version":"3.51.4"},"reference-count":22,"publisher":"Scientific Scholar","content-domain":{"domain":["jpalliativecare.com"],"crossmark-restriction":true},"short-container-title":["IJPC"],"abstract":"\n Objectives:<\/jats:title>\n Oesophageal cancer (OC) is characterised by poor prognosis, a significant reduction in Quality of Life (QoL) and requirement for morbid therapy. The highest age-adjusted rate of OC incidence in India was seen in the East Khasi Hills district of Meghalaya, being 10 times the national average. This study aimed to develop and validate Khasi translations of the European Organisation for Research and Treatment of Cancer Core Quality of Life questionnaire (EORTC QLQ-C-30) Version 3.0 and EORTC QLQ-OES-18 questionnaires for use in the Khasi-speaking population of Meghalaya.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n This study was conducted as a part of a hospital-based cross-sectional study to develop and validate a Khasi-translated version of the QLQ-C-30 and QLQ-OES-18 questionnaires. The questionnaire was translated into the local (Khasi) language and validated (two-phase process: Two forward translations, two backward translations, followed by pilot testing). Reliability assessment was done using Cronbach\u2019s alpha. The construct validity and the correlation of each scale of the QLQ-C30 and QLQ-OES18 were evaluated using Spearman\u2019s correlation coefficient (r).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Cronbach\u2019s alpha was satisfactory (>0.70) for all the scales of QLQ-C-30 and QLQ-OES-18. Convergent validity was moderate to high (r = 0.541 to 0.995) (Global health domain convergent validity r = 0.983\u20130.995), whereas discriminant validity was acceptably low (Global health domain divergent validity of r = 0.006\u20130.474) for all scales. Correlation coefficient values for each scale between QLQ-C-30 and QLQ-OES-18 ranged from 0.001 to 0.557.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The Khasi versions of the QLQ-C-30 and QLQ-OES-18 demonstrate good psychometric validity, proving to be a reliable and culturally appropriate valuable tool for assessing QoL in OC patients in the Khasi-speaking population of North-East India.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/ijpc_192_2025","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T17:46:29Z","timestamp":1774028789000},"page":"175-182","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Translation and Validation of the Khasi version of European Organisation for Research and Treatment of Cancer Core Quality of Life Questionnaire (EORTC QLQ-C-30) and Oesophageal Cancer module (EORTC QLQ-OES-18)"],"prefix":"10.25259","volume":"32","author":[{"given":"Samapti","family":"Debnath","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caleb","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanthosh Priyan","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"10.25259\/IJPC_192_2025\/ref-1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.25259\/IJPC_192_2025\/ref-2","article-title":"World Health Organization","author":"International Agency for Research on Cancer","year":"2020"},{"key":"10.25259\/IJPC_192_2025\/ref-3","doi-asserted-by":"publisher","first-page":"2074","DOI":"10.1056\/NEJMoa1112088","article-title":"Preoperative chemoradiotherapy for esophageal or junctional cancer","volume":"366","author":"Van Hagen","year":"2012","journal-title":"N Engl J Med"},{"key":"10.25259\/IJPC_192_2025\/ref-4","article-title":"Indian Council of Medical Research - National Centre for Disease Informatics and Research","author":"National Cancer Registry Programme. Reports of National Cancer Registry Programme","year":"2020","journal-title":"Banglore"},{"key":"10.25259\/IJPC_192_2025\/ref-6","doi-asserted-by":"publisher","first-page":"S125","DOI":"10.1111\/j.1524-4733.2007.00275.x","article-title":"Patient-reported outcomes to support medical product labeling claims: FDA perspective","volume":"10","author":"Patrick","year":"2007","journal-title":"Value Health"},{"key":"10.25259\/IJPC_192_2025\/ref-7","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1586\/14737167.8.2.179","article-title":"Prognostic factor analysis of health-related quality of life data in cancer: A statistical methodological evaluation","volume":"8","author":"Mauer","year":"2008","journal-title":"Expert Rev Pharmacoecon Outcomes Res"},{"key":"10.25259\/IJPC_192_2025\/ref-8","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1200\/JCO.2007.13.3439","article-title":"The prognostic significance of patient-reported outcomes in cancer clinical trials","volume":"26","author":"Gotay","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.25259\/IJPC_192_2025\/ref-9","doi-asserted-by":"publisher","first-page":"119","DOI":"10.21037\/acs.2017.03.14","article-title":"8th edition. AJCC\/UICC staging of cancers of the esophagus and esophagogastric junction: Application to clinical practice","volume":"6","author":"Rice","year":"2017","journal-title":"Ann Cardiothorac Surg"},{"key":"10.25259\/IJPC_192_2025\/ref-10","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.69583","article-title":"Anatomy of Esophagus. Esophageal Abnormalities","author":"Ferhatoglu","year":"2017","journal-title":"Intech"},{"key":"10.25259\/IJPC_192_2025\/ref-11","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The european organisation for research and treatment of cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology","volume":"85","author":"Aaronson","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"10.25259\/IJPC_192_2025\/ref-12","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1016\/S0959-8049(03)00270-3","article-title":"Clinical and psychometric validation of an eortc questionnaire module, the EORTC QLQ-OES18, to assess quality of life in patients with oesophageal cancer","volume":"39","author":"Blazeby","year":"2003","journal-title":"Eur J Cancer"},{"key":"10.25259\/IJPC_192_2025\/ref-13","volume-title":"Fourth Edition","author":"Kulis","year":"2017"},{"key":"10.25259\/IJPC_192_2025\/ref-14","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/BF02310555","article-title":"Coefficient alpha and the internal structure of tests","volume":"16","author":"Cronbach","year":"1951","journal-title":"Psychometrika"},{"key":"10.25259\/IJPC_192_2025\/ref-15","volume-title":"Eortc qlq-c30 scoring manual. Rd edn. Brussels: EORTC","author":"Fayers","year":"2001"},{"key":"10.25259\/IJPC_192_2025\/ref-16","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.ejca.2012.09.037","article-title":"Validation of the reflux scale in the european organisation for research and treatment of cancer QLQ-OES18","volume":"49","author":"Lagergren","year":"2013","journal-title":"Eur J Cancer"},{"key":"10.25259\/IJPC_192_2025\/ref-17","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1007\/s00268-011-1123-6","article-title":"Long-term health-related quality of life for disease-free esophageal cancer patients","volume":"35","author":"Donohoe","year":"2011","journal-title":"World J Surg"},{"key":"10.25259\/IJPC_192_2025\/ref-18","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.jtcvs.2014.12.063","article-title":"Outcomes, quality of life, and survival after esophagectomy for squamous cell carcinoma: A propensity score-matched comparison of operative approaches","volume":"149","author":"Wang","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.25259\/IJPC_192_2025\/ref-19","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s41687-021-00354-6","article-title":"Translation and validation of the urdu version of the european organization for research and treatment of cancer core quality of life questionnaire (EORTC QLQ-C30) and brain module (QLQ-BN20) in primary brain tumor patients","volume":"5","author":"Zahid","year":"2021","journal-title":"J Patient Rep Outcomes"},{"key":"10.25259\/IJPC_192_2025\/ref-20","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1007\/s11136-010-9675-8","article-title":"Quality of life of patients with esophageal cancer in taiwan: Validation and application of the taiwan chinese (mandarin) version of the EORTC QLQ-OES18: A brief communication","volume":"19","author":"Chie","year":"2010","journal-title":"Qual Life Res"},{"key":"10.25259\/IJPC_192_2025\/ref-21","first-page":"855","article-title":"Development and evaluation on quality-of-life questionnaire for esophageal cancer patients during chemotherapy, chinese version","volume":"16","author":"Qian","year":"2007","journal-title":"Chin J Oncol"},{"key":"10.25259\/IJPC_192_2025\/ref-22","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s00268-005-7887-9","article-title":"Influence of surgery-related factors on quality of life after esophageal or cardia cancer resection","volume":"29","author":"Viklund","year":"2005","journal-title":"World J Surg"},{"key":"10.25259\/IJPC_192_2025\/ref-23","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1007\/s13193-025-02186-y","article-title":"Quality of life (QoL) among patients with esophageal cancer using validated european organisation for research and treatment of cancer (EORTC)-A hospital-based cross-sectional study","volume":"16","author":"Debnath","year":"2025","journal-title":"Indian J Surg Oncol"}],"container-title":["Indian Journal of Palliative Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jpalliativecare.com\/translation-and-validation-of-the-khasi-version-of-european-organisation-for-research-and-treatment-of-cancer-core-quality-of-life-questionnaire-eortc-qlq-c-30-and-oesophageal-cancer-module-eortc-q\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpalliativecare.com\/translation-and-validation-of-the-khasi-version-of-european-organisation-for-research-and-treatment-of-cancer-core-quality-of-life-questionnaire-eortc-qlq-c-30-and-oesophageal-cancer-module-eortc-q\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T06:02:07Z","timestamp":1778652127000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpalliativecare.com\/translation-and-validation-of-the-khasi-version-of-european-organisation-for-research-and-treatment-of-cancer-core-quality-of-life-questionnaire-eortc-qlq-c-30-and-oesophageal-cancer-module-eortc-q\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,20]]},"references-count":22,"alternative-id":["10.25259\/IJPC_192_2025"],"URL":"https:\/\/doi.org\/10.25259\/ijpc_192_2025","relation":{},"ISSN":["1998-3735","0973-1075"],"issn-type":[{"value":"1998-3735","type":"electronic"},{"value":"0973-1075","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,20]]},"article-number":"175"}}