{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:34:18Z","timestamp":1759336458808},"reference-count":35,"publisher":"Scientific Scholar","content-domain":{"domain":["jpalliativecare.com"],"crossmark-restriction":true},"short-container-title":["IJPC"],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Objectives:<\/jats:title>\n<jats:p>This study aimed to describe the clinical experience of the health-care professionals (HCPs) responsible for the introduction of methadone, for the treatment of complex cancer pain, at a low-resource hospital in India in a patient-group, burdened by illiteracy, and low socio-economic status.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Materials and Methods:<\/jats:title>\n<jats:p>Ten HCPs: Four medical doctors, four nurses, one pharmacist, and one hospital administrator were interviewed. The interviews are examined using a qualitative conventional content analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results:<\/jats:title>\n<jats:p>The interviews showed a confidence amongst the HCPs, responsible for the safe introduction of methadone in a stressful and low-resource surrounding, to patients with cancer pain and the different aspects of methadone, as initiation, titration, and maintenance of treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Introduction of methadone for cancer pain management is safe and feasible although low resources in a challenging hospital setting and care environment.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/ijpc_383_20","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T05:23:10Z","timestamp":1637299390000},"page":"382-404","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Introduction and Experiences of Methadone for Treatment of Cancer Pain at a Low-resource Governmental Cancer Center in India"],"prefix":"10.25259","volume":"27","author":[{"given":"Gayatri","family":"Palat","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, MNJ Institute of Oncology and Regional Cancer Centre, Hyderabad, Telangana, India,"},{"name":"Department of Palliative Access (PAX) Program, MNJ Institute of Oncology and Regional Cancer Centre, Hyderabad, Telangana, India,"},{"name":"Two-Worlds Cancer Collaboration-INCTR, Vancouver, British Columbia, Canada,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Algotsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spandana","family":"Rayala","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, MNJ Institute of Oncology and Regional Cancer Centre, Hyderabad, Telangana, India,"},{"name":"Department of Pain Relief and Palliative Care Society, MNJ Institute of Oncology and Regional Cancer Centre, Hyderabad, Telangana, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Gebre-Medhin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Oncology, Lund University, Sweden,"},{"name":"Department of Radiotherapy and Radiophysics, Skane University Hospital, Lund, Sweden,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Brun","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Oncology, Lund University, Sweden,"},{"name":"Department of Radiotherapy and Radiophysics, Skane University Hospital, Lund, Sweden,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Segerlantz","sequence":"additional","affiliation":[{"name":"Department of Palliative Care and Advanced Home Health Care, Primary Health Care Skane, Region Skane, Lund, Sweden,"},{"name":"Department of Clinical Sciences, Oncology and Pathology, Institute for Palliative Care, Lund University, Lund, Sweden,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2021,11,19]]},"reference":[{"key":"10.25259\/IJPC_383_20\/ref-1","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/S0885-3924(02)00497-9","article-title":"Cancer pain and psychosocial factors: A critical review of the literature","volume":"24","author":"Zaza","year":"2002","journal-title":"J Pain Symptom Manage"},{"key":"10.25259\/IJPC_383_20\/ref-2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s11916-011-0190-6","article-title":"Psychosocial issues in cancer pain","volume":"15","author":"Porter","year":"2011","journal-title":"Curr Pain Headache Rep"},{"key":"10.25259\/IJPC_383_20\/ref-3","doi-asserted-by":"publisher","first-page":"3759","DOI":"10.1007\/s00520-017-3806-5","article-title":"Multicenter, cross-sectional observational study of the impact of neuropathic pain on quality of life in cancer patients","volume":"25","author":"Oh","year":"2017","journal-title":"Support Care Cancer"},{"key":"10.25259\/IJPC_383_20\/ref-4","first-page":"14","author":"World Health Organization","year":"1996","edition":"2nd ed"},{"key":"10.25259\/IJPC_383_20\/ref-5","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1007\/s00520-018-4471-z","article-title":"Optimizing cancer pain management in resource-limited settings","volume":"27","author":"Ahmedzai","year":"2019","journal-title":"Support Care Cancer"},{"key":"10.25259\/IJPC_383_20\/ref-6","article-title":"The First Ever Global Survey on Availability and Barriers to Access of Opioid Analgesics for Patients in Pain","author":"Global Access to Pain Relief: Evidence for Action","year":"2020"},{"key":"10.25259\/IJPC_383_20\/ref-7","article-title":"Model List of Essential Medicines","author":"World Health Organization","year":"2019"},{"key":"10.25259\/IJPC_383_20\/ref-8","article-title":"Report of International Narcotics Control Board for 2004","author":"United Nations","year":"2006"},{"key":"10.25259\/IJPC_383_20\/ref-9","first-page":"208","article-title":"Availability and utilization of opioids for pain management: Global issues","volume":"14","author":"Manjiani","year":"2014","journal-title":"Ochsner J"},{"key":"10.25259\/IJPC_383_20\/ref-10","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3109\/15360288.2010.536307","article-title":"A first comparison between the consumption of and the need for opioid analgesics at country, regional, and global lejvels","volume":"25","author":"Seya","year":"2011","journal-title":"J Pain Palliat Care Pharmacother"},{"key":"10.25259\/IJPC_383_20\/ref-11","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1093\/qjmed\/hct080","article-title":"Cancer pain and opioid use-a global issue","volume":"106","author":"O'Brien","year":"2013","journal-title":"QJM"},{"key":"10.25259\/IJPC_383_20\/ref-12","article-title":"Pallium India NDPS Amendment Act","year":"2014"},{"key":"10.25259\/IJPC_383_20\/ref-13","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.4103\/IJPC.IJPC_201_17","article-title":"Methadone is now available in India: Is the long battle over?","volume":"24","author":"Rajagopal","year":"2018","journal-title":"Indian J Palliat Care"},{"key":"10.25259\/IJPC_383_20\/ref-14","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1191\/0269216303pm815oa","article-title":"Low-dose methadone has an analgesic effect in neuropathic pain: A double-blind randomized controlled crossover trial","volume":"17","author":"Makin","year":"2003","journal-title":"Palliat Med"},{"key":"10.25259\/IJPC_383_20\/ref-15","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1089\/jpm.2019.0253","article-title":"The use of low-dose methadone as add-on to regular opioid therapy in cancer-related pain at end of life: A national swedish survey in specialized palliative care","volume":"23","author":"Furst","year":"2019","journal-title":"J Palliat Med"},{"key":"10.25259\/IJPC_383_20\/ref-16","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1200\/JCO.2004.03.172","article-title":"Methadone versus morphine as a first-line strong opioid for cancer pain: A randomized, double-blind study","volume":"22","author":"Bruera","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.25259\/IJPC_383_20\/ref-17","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1007\/s00018-019-03047-y","article-title":"Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain","volume":"76","author":"Deng","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"10.25259\/IJPC_383_20\/ref-18","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1053\/eujp.1999.0154","article-title":"Wind-up and the NMDA receptor complex from a clinical perspective","volume":"4","author":"Eide","year":"2000","journal-title":"Eur J Pain"},{"key":"10.25259\/IJPC_383_20\/ref-19","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.phrs.2004.05.002","article-title":"Methadone-metabolism, pharmacokinetics and interactions","volume":"50","author":"Ferrari","year":"2004","journal-title":"Pharmacol Res"},{"key":"10.25259\/IJPC_383_20\/ref-20","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.jpain.2014.01.494","article-title":"Methadone safety: A clinical practice guideline from the American pain society and college on problems of drug dependence, in collaboration with the heart rhythm society","volume":"15","author":"Chou","year":"2014","journal-title":"J Pain"},{"key":"10.25259\/IJPC_383_20\/ref-21","doi-asserted-by":"publisher","first-page":"825","DOI":"10.2146\/ajhp070392","article-title":"Methadone-associated Q-T interval prolongation and torsades de pointes","volume":"66","author":"Stringer","year":"2009","journal-title":"Am J Health Syst Pharm"},{"key":"10.25259\/IJPC_383_20\/ref-22","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1002\/pds.1112","article-title":"QT prolongation and torsades de pointes among methadone users: reports to the FDA spontaneous reporting system","volume":"14","author":"Pearson","year":"2005","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.25259\/IJPC_383_20\/ref-23","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/S0304-3959(03)00205-7","article-title":"QTc interval prolongation associated with intravenous methadone","volume":"105","author":"Kornick","year":"2003","journal-title":"Pain"},{"key":"10.25259\/IJPC_383_20\/ref-24","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S1526-5900(03)00556-X","article-title":"Management of opioid side effects in cancer-related and chronic noncancer pain: A systematic review","volume":"4","author":"McNicol","year":"2003","journal-title":"J Pain"},{"key":"10.25259\/IJPC_383_20\/ref-25","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.4103\/IJPC.IJPC_186_17","article-title":"Practical guide for using methadone in pain and palliative care practice","volume":"24","author":"Palat","year":"2018","journal-title":"Indian J Palliat Care"},{"key":"10.25259\/IJPC_383_20\/ref-26","doi-asserted-by":"publisher","first-page":"133","DOI":"10.4103\/IJPC.IJPC_109_20","article-title":"The use of methadone in pediatric cancer pain a retrospective study from a governmental cancer center in India","volume":"27","author":"Palat","year":"2021","journal-title":"Indian J Palliat Care"},{"key":"10.25259\/IJPC_383_20\/ref-27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.4103\/IJPC.IJPC_275_20","article-title":"The use of methadone in adult patients with cancer pain at a governmental cancer center in India","volume":"27","author":"Palat","year":"2021","journal-title":"Indian J Palliat Care"},{"key":"10.25259\/IJPC_383_20\/ref-28","article-title":"MNJ Institute of Oncology About MNJ","year":"2009"},{"key":"10.25259\/IJPC_383_20\/ref-29","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1177\/1049732305276687","article-title":"Three approaches to qualitative content analysis","volume":"15","author":"Hsiu-Fang","year":"2005","journal-title":"Qual Health Res"},{"key":"10.25259\/IJPC_383_20\/ref-30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1089\/jpm.2009.0184","article-title":"The effect of oral methadone on the QTc interval in advanced cancer patients: A prospective pilot study","volume":"13","author":"Reddy","year":"2010","journal-title":"J Palliat Med"},{"key":"10.25259\/IJPC_383_20\/ref-31","doi-asserted-by":"publisher","first-page":"CD003971","DOI":"10.1002\/14651858.CD003971.pub4","article-title":"Methadone for cancer pain","volume":"2","author":"Nicholson","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.25259\/IJPC_383_20\/ref-32","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.jpainsymman.2017.10.017","article-title":"Methadone as a first-line opioid in cancer pain management: A systematic review","volume":"55","author":"Mercadante","year":"2018","journal-title":"J Pain Symptom Manage"},{"key":"10.25259\/IJPC_383_20\/ref-33","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1177\/1049909118811904","article-title":"Evaluation of QTc interval prolongation among patients with cancer using enteral methadone","volume":"36","author":"Lovell","year":"2019","journal-title":"Am J Hosp Palliat Care"},{"key":"10.25259\/IJPC_383_20\/ref-34","doi-asserted-by":"publisher","first-page":"131","DOI":"10.5055\/jom.2016.0325","article-title":"Methadone prolongs cardiac conduction in young patients with cancer-related pain","volume":"12","author":"Anghelescu","year":"2016","journal-title":"J Opioid Manag"},{"issue":"11","key":"10.25259\/IJPC_383_20\/ref-35","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26614","article-title":"The frequency of QTc prolongation among pediatric and young adult patients receiving methadone for cancer pain","volume":"64","author":"Madden","year":"2017","journal-title":"Pediatr Blood Cancer"}],"container-title":["Indian Journal of Palliative Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jpalliativecare.com\/the-introduction-and-experiences-of-methadone-for-treatment-of-cancer-pain-at-a-low-resource-governmental-cancer-center-in-india\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jpalliativecare.com\/the-introduction-and-experiences-of-methadone-for-treatment-of-cancer-pain-at-a-low-resource-governmental-cancer-center-in-india\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T07:24:10Z","timestamp":1679297050000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpalliativecare.com\/the-introduction-and-experiences-of-methadone-for-treatment-of-cancer-pain-at-a-low-resource-governmental-cancer-center-in-india\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,19]]},"references-count":35,"alternative-id":["10.25259\/IJPC_383_20"],"URL":"https:\/\/doi.org\/10.25259\/ijpc_383_20","relation":{},"ISSN":["1998-3735","0973-1075"],"issn-type":[{"value":"1998-3735","type":"electronic"},{"value":"0973-1075","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11,19]]},"article-number":"382"}}