{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T01:44:26Z","timestamp":1773107066864,"version":"3.50.1"},"reference-count":12,"publisher":"Scientific Scholar","content-domain":{"domain":["jcasonline.com"],"crossmark-restriction":true},"short-container-title":["JCAS"],"abstract":"\nObjectives:<\/jats:title>\nEvaluate the controlled release of silicon from smart polydioxanone suture (Smart PDOs\u2122) and the clinical effect of the Cartesian Technique\u2122 in face lifting.<\/jats:p>\n<\/jats:sec>\n\nMaterial and Methods:<\/jats:title>\nThis study was preclinical and clinical trials randomized, uncontrolled, and phase I carried out. Preclinical trials included instrumental analysis of silicon-enriched sutures by light microscopy, electron microscopy, and Ultraviolet-visible (UV-vis) spectroscopy. The clinical trial included 35 patients with primary and secondary rhytides, grade I lipomatosis, and grade I deflation. Polydioxanone (PDO) sutures are inserted following the Cartesian Technique\u2122, a vectorial lift from the intersection of the Cartesian planes of the face. Once the cannulas were inserted with the PDO thread, 0.1 mL of organic silicon was dosed. Turgidity was examined by the pinch test of skin turgor. To measure the position of flaccid or deflated tissues, the scale used was the deflation scale.<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:title>\nThe controlled release of organic silicon from the PDO sutures was verified. Its clinical application revealed that after 8 days the improvement in turgidity, wrinkle reversal, and flaccidity tightening was maintained in 100% of the sample. At 15 days, reversal of rhytides was observed, softening of deep furrows in 80%, and the initial turgor and skin tightening maintained without deflation in 90% of cases. Histopathological findings reveal that silicon synergistically potentiates the tissue effect of the PDO suture, generating greater biostimulation of fibroblasts with better quality collagen fibers, greater restructuring and redensification of the skin, and avoiding the late inflammatory response.<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nThe Cartesian Technique\u2122 with Smart PDOs\u2122 is an effective protocol for skin replenishment that enhances cell biostimulation through the release of bioactive drugs.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/jcas_191_22","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T12:39:59Z","timestamp":1729514399000},"page":"292-306","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Smart PDOs\u2122 and the Cartesian Technique\u2122: A milestone in facial rejuvenation with bioactive scaffolds"],"prefix":"10.25259","volume":"17","author":[{"given":"Gladys Josefina","family":"Velazco de Maldonado","sequence":"first","affiliation":[{"name":"Latin American Center for Research and Training in Minimally Invasive Surgery Foundation, Bogot\u00e1, Colombia,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dubraska Violeta","family":"Suarez-Vega","sequence":"additional","affiliation":[{"name":"Department of Research, Dental Research Center, Faculty of Dentistry, University of Los Andes, M\u00e9rida, Venezuela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Miller-Kobisher","sequence":"additional","affiliation":[{"name":"Department of Academic Research, Pan American Institute of Scientific Professionals, Mexico City, Mexico,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garc\u00eda-Guevara","family":"V\u00edctor","sequence":"additional","affiliation":[{"name":"Department of Academic Research, Foundation Center for Aesthetic Medicine Studies, Caracas, Venezuela,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2024,10,21]]},"reference":[{"key":"10.25259\/jcas_191_22\/ref-1","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.21873\/invivo.11623","article-title":"Evaluation of biocompatibility of different membrane surfaces using unrestricted somatic stem cells","volume":"33","author":"Schorn","year":"2019","journal-title":"In Vivo"},{"key":"10.25259\/jcas_191_22\/ref-2","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.ejpb.2015.05.024","article-title":"Polydioxanone-based bio-materials for tissue engineering and drug\/gene delivery applications","volume":"97","author":"Goonoo","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"key":"10.25259\/jcas_191_22\/ref-3","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.polymertesting.2018.10.007","article-title":"Medical grade polylactide, copolyesters and polydioxanone: Rheological properties and melt stability","volume":"72","author":"Ahlinder","year":"2018","journal-title":"Polym Test"},{"key":"10.25259\/jcas_191_22\/ref-4","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/DSS.0000000000000585","article-title":"Novel polydioxanone multifilament scaffold device for tissue regeneration","volume":"42","author":"Kim","year":"2016","journal-title":"Dermatol Surg"},{"key":"10.25259\/jcas_191_22\/ref-5","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1111\/jocd.12714","article-title":"Multipolydioxanone scaffold improves upper lip and forehead wrinkles: A 12-month outcome","volume":"18","author":"Ko","year":"2019","journal-title":"J Cosmet Dermatol"},{"key":"10.25259\/jcas_191_22\/ref-6","doi-asserted-by":"publisher","first-page":"825455","DOI":"10.3389\/fcell.2022.825455","article-title":"Editorial: Biomimetic materials for tissue regenerations","volume":"10","author":"Rajan","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.25259\/jcas_191_22\/ref-7","first-page":"1","article-title":"Facial deflation vs lipomatosis myths and realities","volume":"7","author":"Velazco","year":"2017","journal-title":"Bioclinical Act"},{"key":"10.25259\/jcas_191_22\/ref-8","doi-asserted-by":"publisher","first-page":"112","DOI":"10.4103\/JCAS.JCAS_116_19","article-title":"Innovative paradigm in aesthetics medicine: Proposal for diagnostic morphological geometric by thirds, semiology in clinical applied to aging facial","volume":"13","author":"Velazco de Maldonado","year":"2020","journal-title":"J Cutan Aesthet Surg"},{"key":"10.25259\/jcas_191_22\/ref-9","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1039\/C3BM60211G","article-title":"Poly(ester-ether)s: II. Properties of electrospun nanofibres from polydioxanone and poly (methyl dioxanone) blends and human fibroblast cellular proliferation","volume":"2","author":"Goonoo","year":"2014","journal-title":"Biomater Sci"},{"key":"10.25259\/jcas_191_22\/ref-10","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.3390\/polym14091637","article-title":"Electrospun medical sutures for wound healing: A review","volume":"14","author":"Xu","year":"2022","journal-title":"Polymers"},{"key":"10.25259\/jcas_191_22\/ref-11","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1002\/jbm.a.37194","article-title":"Engineering and polymeric composition of drug-eluting suture: A review","volume":"109","author":"Deng","year":"2021","journal-title":"J Biomed Mater Res A"},{"key":"10.25259\/jcas_191_22\/ref-12","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3390\/polym12020288","article-title":"Controllable drug release behavior of polylactic acid (PLA) surgical suture coating with ciprofloxacin (CPFX)-polycaprolactone (PCL)\/polyglycolide (PGA)","volume":"12","author":"Liu","year":"2020","journal-title":"Polymers"}],"container-title":["Journal of Cutaneous and Aesthetic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/jcasonline.com\/smart-pdos-and-the-cartesian-technique-a-milestone-in-facial-rejuvenation-with-bioactive-scaffolds\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/jcasonline.com\/smart-pdos-and-the-cartesian-technique-a-milestone-in-facial-rejuvenation-with-bioactive-scaffolds\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T06:06:51Z","timestamp":1729577211000},"score":1,"resource":{"primary":{"URL":"https:\/\/jcasonline.com\/smart-pdos-and-the-cartesian-technique-a-milestone-in-facial-rejuvenation-with-bioactive-scaffolds\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,21]]},"references-count":12,"alternative-id":["10.25259\/jcas_191_22"],"URL":"https:\/\/doi.org\/10.25259\/jcas_191_22","relation":{},"ISSN":["0974-5157","0974-2077"],"issn-type":[{"value":"0974-5157","type":"electronic"},{"value":"0974-2077","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,21]]},"article-number":"292"}}