{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T05:26:34Z","timestamp":1739337994554,"version":"3.37.0"},"reference-count":7,"publisher":"Scientific Scholar","content-domain":{"domain":["jcasonline.com"],"crossmark-restriction":true},"short-container-title":["JCAS"],"abstract":"\nObjectives:<\/jats:title>\nThe study aimed to compare the efficacy of two treatment modalities in vitiligo vulgaris that is \u2013 potent topical corticosteroid (betamethasone-dipropionate lotion 0.05%) with FrCO2<\/jats:sub> laser versus Potent topical corticosteroid (PTS) alone, and to observe side effects if any.<\/jats:p>\n<\/jats:sec>\n\nMaterial and Methods:<\/jats:title>\nSixty cases with stable vitiligo (vitiligo vulgaris including focal vitiligo) >12 years of age with <27% body surface area were included in the study. The Institutional Ethics Committee approval was taken. After taking consent and clinical photographs, cases were randomly allocated into two groups of 30 patients each: Group A received FrCO2<\/jats:sub> laser (power-6W, random mode) once a month + twice daily application of PTS (betamethasone dipropionate lotion 0.05%) over patches and Group B applied PTS only twice daily (betamethasone dipropionate lotion 0.05%). The response was assessed at the end of 3 months.<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:title>\nThe mean vitiligo area scoring index (VASI) score at baseline for Group A was 1.17 \u00b1 0.59, and after 3 months was 0.60 \u00b1 0.56. For Group B, the mean VASI at baseline was 0.87 \u00b1 0.35 and after 3 months was 0.63 \u00b1 0.50. The p value of group B was 0.003 and for group A was 0.001. Even though the reduction in mean VASI was statistically significant in both groups, Group A showed a better response. Group A showed good to excellent response in 16.67% while Group B only cases in 3.3%. This suggests that the addition of FrCO2<\/jats:sub> to steroids may provide superior repigmentation.<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nThe addition of FrCO2<\/jats:sub> laser to topical corticosteroids offers a safe and promising approach and can be considered in patients who are unresponsive to other treatment modalities.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/jcas_84_2024","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T12:43:51Z","timestamp":1739277831000},"page":"42-47","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A comparative study of the efficacy of potent topical corticosteroids per se versus combination of potent topical corticosteroids with fractional CO2<\/sub> laser in the management of vitiligo vulgaris"],"prefix":"10.25259","volume":"18","author":[{"given":"Kishan","family":"Ninama","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venerology and Leprosy, Smt Bhikhiben K Shah Medical Institute and Research Center, Vadodara, Gujarat, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashmi","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Leprosy, Smt Bhikhiben K Shah Medical Institute and Research Center, Vadodara, Gujarat, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Disha","family":"Baxi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Leprosy, Smt Bhikhiben K Shah Medical Institute and Research Center, Vadodara, Gujarat, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raveena Sanjay","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Leprosy, Smt Bhikhiben K Shah Medical Institute and Research Center, Vadodara, Gujarat, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogesh","family":"Marfatia","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Leprosy, Smt Bhikhiben K Shah Medical Institute and Research Center, Vadodara, Gujarat, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"10.25259\/JCAS_84_2024\/ref-1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1097\/01.EWX.0000418013.96072.66","article-title":"Phototherapy in vitiligo: A comparative evaluation of various therapeutic modalities","volume":"9","author":"El-Mofty","year":"2012","journal-title":"J Egypt Women Dermatol Soc"},{"key":"10.25259\/JCAS_84_2024\/ref-2","first-page":"2","article-title":"A randomized trial to evaluate the efficacy and safety of 1% pimecrolimus cream vs. 0.05% clobetasol propionate cream for the treatment of childhood vitiligo","volume":"3","author":"Sharma","year":"2018","journal-title":"J Dermatitis"},{"key":"10.25259\/JCAS_84_2024\/ref-3","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1111\/jocd.12397","article-title":"Combined treatment with fractional carbon dioxide laser, autologous platelet-rich plasma, and narrow band ultraviolet B for vitiligo in different body sites: A prospective, randomized comparative trial","volume":"17","author":"Abdelghani","year":"2018","journal-title":"J Cosmet Dermatol"},{"key":"10.25259\/JCAS_84_2024\/ref-4","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1002\/lsm.22821","article-title":"Preliminary study on the treatment of vitiligo with carbon dioxide fractional laser together with tacrolimus","volume":"50","author":"Chen","year":"2018","journal-title":"Lasers Surg Med"},{"key":"10.25259\/JCAS_84_2024\/ref-5","doi-asserted-by":"publisher","first-page":"e12747","DOI":"10.1111\/dth.12747","article-title":"A preliminary study of fractional CO2 laser added to topical tacrolimus combined with 308 nm excimer lamp for refractory vitiligo","volume":"32","author":"Wen","year":"2019","journal-title":"Dermatol Ther"},{"key":"10.25259\/JCAS_84_2024\/ref-6","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1002\/lsm.22389","article-title":"Effects of a preceding fractional carbon dioxide laser on the outcome of combined local narrowband ultraviolet B and topical steroids in patients with vitiligo in difficult-to-treat areas","volume":"48","author":"Vachiramon","year":"2016","journal-title":"Lasers Surg Med"},{"key":"10.25259\/JCAS_84_2024\/ref-7","doi-asserted-by":"publisher","first-page":"e14604","DOI":"10.1111\/dth.14604","article-title":"A comparative study on the use of Fractional CO2 laser with Tacrolimus or Calcipotriol or NB-UVB in treatment of stable non segmental vitiligo","volume":"34","author":"Bakr","year":"2020","journal-title":"Dermatol Ther"}],"container-title":["Journal of Cutaneous and Aesthetic 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