{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:23:32Z","timestamp":1783038212570,"version":"3.54.6"},"reference-count":14,"publisher":"Scientific Scholar","content-domain":{"domain":["clinicalimagingscience.org"],"crossmark-restriction":true},"short-container-title":["JCIS"],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Objectives:<\/jats:title>\n<jats:p>This study aimed to evaluate the CT and MRI findings of focal splenic lesions and ascites in generalized lymphatic anomaly (GLA), kaposiform lymphangiomatosis (KLA), and Gorham-Stout disease (GSD).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Material and Methods:<\/jats:title>\n<jats:p>Twenty-three patients (10 with GLA, 5 with KLA, and 8 with GSD) who underwent abdominal CT and\/or MRI before treatment were included in this study, and their imaging findings were retrospectively evaluated.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results:<\/jats:title>\n<jats:p>Focal splenic lesions were observed in nine patients; these lesions were observed frequently in GLA (<jats:italic>n<\/jats:italic> = 5; 50%) or KLA (<jats:italic>n<\/jats:italic> = 3; 60%) compared with GSD (<jats:italic>n<\/jats:italic> = 1; 13%); however, no significant differences were found between the three groups (<jats:italic>P<\/jats:italic> = 0.190). On CT images among eight patients (4 with GLA, 3 with KLA, and 1 with GSD) with focal splenic lesions who underwent CT, the number of focal splenic lesions per patient ranged from 2 to 189 (mean, 42) and the maximum diameter of focal splenic lesions ranged from 2 to 39 mm (mean, 8 mm), while more than 30 focal splenic lesions per patient were observed in 2 (50%) GLA and focal splenic lesions with maximum diameters of \u226510 mm were observed in 4 (100%) GLA but not in KLA or GSD. Ascites was observed in five patients; significant differences were observed among KLA (<jats:italic>n<\/jats:italic> = 4; 80%), GLA (<jats:italic>n<\/jats:italic> = 1; 10%), and GSD (<jats:italic>n<\/jats:italic> = 0; 0%) (<jats:italic>P<\/jats:italic> &lt; 0.01). Ascites was significantly more frequent in KLA than in GSD (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>More than 30 focal splenic lesions per patient and\/or focal splenic lesions with maximum diameters of \u226510 mm were observed only in GLA. Focal splenic lesions tended to be less frequent in GSD, whereas ascites tended to be frequent in KLA.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/jcis_101_2021","type":"journal-article","created":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T05:52:53Z","timestamp":1628920373000},"page":"44","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["CT and MRI Findings of Focal Splenic Lesions and Ascites in Generalized Lymphatic Anomaly, Kaposiform Lymphangiomatosis, and Gorham-Stout Disease"],"prefix":"10.25259","volume":"11","author":[{"given":"Fumihiko","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Radiology, Gifu University, Gifu, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gifu University, Gifu, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michio","family":"Ozeki","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gifu University, Gifu, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gifu University, Gifu, Japan,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,8,14]]},"reference":[{"key":"10.25259\/JCIS_101_2021\/ref-1","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1002\/pbc.25914","article-title":"Clinical features and prognosis of generalized lymphatic anomaly, kaposiform lymphangiomatosis, and gorham-stout disease","volume":"63","author":"Ozeki","year":"2016","journal-title":"Pediatr Blood 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