{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:26:43Z","timestamp":1778628403306,"version":"3.51.4"},"reference-count":20,"publisher":"Scientific Scholar","content-domain":{"domain":["clinicalimagingscience.org"],"crossmark-restriction":true},"short-container-title":["JCIS"],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Objectives:<\/jats:title>\n<jats:p>This study aimed to assess the efficacy of imaging findings when differentiating between human papillomavirus (HPV)-positive and -negative squamous cell carcinomas (SCCs) of the maxillary sinus.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Material and Methods:<\/jats:title>\n<jats:p>This study included 37 patients with histopathologically and immunohistochemically confirmed SCCs of the maxillary sinus (three HPV positive and 34 HPV negative). Apparent diffusion coefficients (ADCs), MR signal intensities, CT findings, and maximum standardized uptake (SUVmax) were correlated with the two pathologies.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results:<\/jats:title>\n<jats:p>The minimum ADC (ADCmin) was significantly lower in HPV-positive SCCs than in HPV-negative SCCs (0.50 \u00b1 0.02 vs. 0.70 \u00b1 0.13 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s, <jats:italic>P<\/jats:italic> &lt; 0.01). The mean ADC (ADCmean) was not significantly different between HPV-positive SCCs and HPV-negative SCCs (0.84 \u00b1 0.07 vs. 0.97 \u00b1 0.18 \u00d710<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s, <jats:italic>P<\/jats:italic> = 0.18). The areas under the receiver operating characteristic curves for ADCmin and ADCmean were 0.986 (<jats:italic>P<\/jats:italic> &lt; 0.01) and 0.754 (<jats:italic>P<\/jats:italic> &lt; 0.05), respectively. The sensitivity and specificity, with a threshold of ADCmin (0.516 \u00d7 10<jats:sup>\u22123<\/jats:sup> mm<jats:sup>2<\/jats:sup>\/s) for a diagnosis of HPV-positive SCCs, were 100% and 96%, respectively. However, no significant differences were observed in MR signal intensities, CT findings, and SUVmax between HPV-positive and HPV-negative SCCs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>ADCmin is a useful parameter for the differentiation of HPV-positive and HPV-negative SCCs of the maxillary sinus.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/jcis_116_2020","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T04:47:29Z","timestamp":1601527649000},"page":"59","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of Imaging Findings between Human Papillomavirus-positive and -Negative Squamous Cell Carcinomas of the Maxillary Sinus"],"prefix":"10.25259","volume":"10","author":[{"given":"Masaya","family":"Kawaguchi","sequence":"first","affiliation":[{"name":"Department of Radiology, Gifu University, Gifu, Japan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gifu University, Gifu, Japan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Tumor Pathology, Gifu University, Gifu, Japan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Tumor Pathology, Gifu University, Gifu, Japan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsuko","family":"Suzui","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gifu University, Gifu, Japan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuhiko","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Pathology, Gifu University, Gifu, Japan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Gifu University, Gifu, Japan,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2020,10,1]]},"reference":[{"key":"10.25259\/JCIS_116_2020\/ref-1","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1056\/NEJMoa0912217","article-title":"Human papillomavirus and survival of patients with oropharyngeal cancer","volume":"363","author":"Ang","year":"2010","journal-title":"N Engl J Med"},{"key":"10.25259\/JCIS_116_2020\/ref-2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1758-3284-2-15","article-title":"Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC)","volume":"2","author":"Dayyani","year":"2010","journal-title":"Head Neck Oncol"},{"key":"10.25259\/JCIS_116_2020\/ref-3","doi-asserted-by":"publisher","first-page":"S104","DOI":"10.1007\/s12105-012-0368-1","article-title":"Human papillomavirus in non-oropharyngeal head and neck cancers: A systematic literature review","volume":"6","author":"Isayeva","year":"2012","journal-title":"Head Neck Pathol"},{"key":"10.25259\/JCIS_116_2020\/ref-4","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/j.ejca.2012.03.014","article-title":"Population-based evidence of increased survival in human papillomavirus-related head and neck cancer","volume":"48","author":"Nygard","year":"2012","journal-title":"Eur J Cancer"},{"key":"10.25259\/JCIS_116_2020\/ref-5","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.oraloncology.2012.06.019","article-title":"Human papillomavirus related head and neck cancer survival: A systematic review and meta-analysis","volume":"48","author":"O'Rorke","year":"2012","journal-title":"Oral Oncol"},{"key":"10.25259\/JCIS_116_2020\/ref-6","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.1002\/cncr.24309","article-title":"Human papillomaviruses are identified in a subgroup of sinonasal squamous cell carcinomas with favorable outcome","volume":"115","author":"Alos","year":"2009","journal-title":"Cancer"},{"key":"10.25259\/JCIS_116_2020\/ref-7","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1002\/lary.26477","article-title":"Outcomes of HPV-related nasal squamous cell carcinoma","volume":"127","author":"Chowdhury","year":"2017","journal-title":"Laryngoscope"},{"key":"10.25259\/JCIS_116_2020\/ref-8","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1002\/alr.21996","article-title":"Significance of human papillomavirus positivity in sinonasal squamous cell carcinoma","volume":"7","author":"Kilic","year":"2017","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.25259\/JCIS_116_2020\/ref-9","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1097\/RCT.0b013e318282d7c3","article-title":"Intranodal cystic changes: A potential radiologic signature\/biomarker to assess the human papillomavirus status of cases with oropharyngeal malignancies","volume":"37","author":"Morani","year":"2013","journal-title":"J Comput Assist Tomogr"},{"key":"10.25259\/JCIS_116_2020\/ref-10","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.3174\/ajnr.A3524","article-title":"Differences in imaging characteristics of HPV-positive and HPV-Negative oropharyngeal cancers: A blinded matched-pair analysis","volume":"34","author":"Cantrell","year":"2013","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.25259\/JCIS_116_2020\/ref-11","doi-asserted-by":"publisher","first-page":"E613","DOI":"10.1002\/hed.24051","article-title":"Correlation of human papillomavirus status with apparent diffusion coefficient of diffusion-weighted MRI in head and neck squamous cell carcinomas","volume":"38","author":"Driessen","year":"2016","journal-title":"Head Neck"},{"key":"10.25259\/JCIS_116_2020\/ref-12","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.3174\/ajnr.A5370","article-title":"Apparent diffusion coefficient histograms of human papillomavirus-positive and human papillomavirus-negative head and neck squamous cell carcinoma: Assessment of tumor heterogeneity and comparison with histopathology","volume":"38","author":"de Perrot","year":"2017","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.25259\/JCIS_116_2020\/ref-13","doi-asserted-by":"publisher","first-page":"763","DOI":"10.3174\/ajnr.A4271","article-title":"Quantitative diffusion-weighted MRI parameters and human papillomavirus status in oropharyngeal squamous cell carcinoma","volume":"36","author":"Schouten","year":"2015","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.25259\/JCIS_116_2020\/ref-14","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1007\/s00405-013-2641-7","article-title":"Use of quantitative diffusion-weighted magnetic resonance imaging to predict human papilloma virus status in patients with oropharyngeal squamous cell carcinoma","volume":"271","author":"Nakahira","year":"2014","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"10.25259\/JCIS_116_2020\/ref-15","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1097\/00125480-200607000-00006","article-title":"p16INK4a immunoexpression: Surrogate marker of high-risk HPV and high-grade cervical intraepithelial neoplasia","volume":"13","author":"Kalof","year":"2006","journal-title":"Adv Anat Pathol"},{"key":"10.25259\/JCIS_116_2020\/ref-16","doi-asserted-by":"publisher","first-page":"2166","DOI":"10.1002\/cncr.25033","article-title":"Comparison of human papillomavirus in situ hybridization and p16 immunohistochemistry in the detection of human papillomavirus-associated head and neck cancer based on a prospective clinical experience","volume":"116","author":"Singhi","year":"2010","journal-title":"Cancer"},{"key":"10.25259\/JCIS_116_2020\/ref-17","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1186\/s40064-015-0974-y","article-title":"Differentiation of extranodal non-Hodgkins lymphoma from squamous cell carcinoma of the maxillary sinus: A multimodality imaging approach","volume":"4","author":"Kato","year":"2015","journal-title":"Springerplus"},{"key":"10.25259\/JCIS_116_2020\/ref-18","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1177\/0284185119828202","article-title":"Apparent diffusion coefficients are closely related with high-risk human papilloma virus infection in cervical squamous cell carcinoma patients","volume":"60","author":"Zhou","year":"2019","journal-title":"Acta Radiol"},{"key":"10.25259\/JCIS_116_2020\/ref-19","doi-asserted-by":"publisher","first-page":"e196","DOI":"10.1097\/RLU.0000000000000691","article-title":"Do 18F-FDG PET\/CT parameters in oropharyngeal and oral cavity squamous cell carcinomas indicate HPV status?","volume":"40","author":"Kendi","year":"2015","journal-title":"Clin Nucl Med"},{"key":"10.25259\/JCIS_116_2020\/ref-20","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s40463-015-0091-5","article-title":"Correlation of PET-CT nodal SUVmax with p16 positivity in oropharyngeal squamous cell carcinoma","volume":"44","author":"Clark","year":"2015","journal-title":"J Otolaryngol Head Neck Surg"}],"container-title":["Journal of Clinical Imaging Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/clinicalimagingscience.org\/comparison-of-imaging-findings-between-human-papillomavirus-positive-and-negative-squamous-cell-carcinomas-of-the-maxillary-sinus\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/clinicalimagingscience.org\/comparison-of-imaging-findings-between-human-papillomavirus-positive-and-negative-squamous-cell-carcinomas-of-the-maxillary-sinus\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T12:17:18Z","timestamp":1679314638000},"score":1,"resource":{"primary":{"URL":"https:\/\/clinicalimagingscience.org\/comparison-of-imaging-findings-between-human-papillomavirus-positive-and-negative-squamous-cell-carcinomas-of-the-maxillary-sinus\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,1]]},"references-count":20,"alternative-id":["10.25259\/JCIS_116_2020"],"URL":"https:\/\/doi.org\/10.25259\/jcis_116_2020","relation":{},"ISSN":["2156-5597","2156-7514"],"issn-type":[{"value":"2156-5597","type":"electronic"},{"value":"2156-7514","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10,1]]},"article-number":"59"}}