{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T14:46:58Z","timestamp":1742395618112},"reference-count":17,"publisher":"Scientific Scholar","content-domain":{"domain":["clinicalimagingscience.org"],"crossmark-restriction":true},"short-container-title":["JCIS"],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Objectives:<\/jats:title>\n<jats:p>The objectives of the study were to evaluate the clinical presentation, cardiac magnetic resonance (CMR) features, and outcomes of patients with dilated cardiomyopathy (DCM).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Material and Methods:<\/jats:title>\n<jats:p>A retrospective study was conducted at a tertiary care center of Pakistan. All patients who underwent CMR for further evaluation of DCM during the period of 2011\u20132019 and in whom CMR confirmed the diagnosis of DCM, were included in the study. Patients were followed up in the year 2020 for all-cause mortality and cardiovascular hospitalizations.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results:<\/jats:title>\n<jats:p>A total of 75 patients were included in the study. The mean age was 38.7 \u00b1 13 with the majority (<jats:italic>n<\/jats:italic> = 57, 76%) being male. Dyspnea was the most common presenting symptom (<jats:italic>n<\/jats:italic> = 68, 90.7%). The mean left ventricle ejection fraction (LVEF) by CMR was 29.3 \u00b1 12 and mean left ventricle stroke volume (LVSV) was 66.5 \u00b1 31. Late gadolinium enhanced (LGE) was present in 28 (37.3%) patients. Follow-up was available in 61 patients with the mean follow-up duration of 39.7 \u00b1 27 months. Most patients (40, 65.6%) experienced all-cause major adverse cardiovascular events (MACE) during the follow-up and mortality was observed in 10 (16.4%) patients. LVSV by CMR (<jats:italic>P<\/jats:italic> = 0.03), LVEF by CMR (<jats:italic>P<\/jats:italic> = 0.02), and presence of pericardial effusion (PE) (<jats:italic>P<\/jats:italic> = 0.01) were significantly associated with all-cause MACE. On multiregression analysis, SV by CMR was associated with all cause MACE (<jats:italic>P<\/jats:italic> = 0.048). The presence of LGE was associated with higher mortality (<jats:italic>P<\/jats:italic> = 0.03).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>LVSV, LVEF by CMR, and PE were significantly associated with all-cause MACE. LGE was associated with higher mortality. Our cohort had a relatively younger age of presentation and diagnosis, and a greater mortality on follow-up, when compared with other regions of the world.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/jcis_126_2021","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T11:47:01Z","timestamp":1627040821000},"page":"40","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical Characteristics, Cardiac Magnetic Resonance Features, and Outcomes of Patients with Dilated Cardiomyopathy \u2013 An Experience from a South Asian Country"],"prefix":"10.25259","volume":"11","author":[{"given":"Pirbhat","family":"Shams","sequence":"first","affiliation":[{"name":"Department of Medicine (Cardiology), Aga Khan University Hospital, Karachi, Sindh, Pakistan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fateh Ali Tipoo","family":"Sultan","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology), Aga Khan University Hospital, Karachi, Sindh, Pakistan,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"10.25259\/JCIS_126_2021\/ref-1","doi-asserted-by":"publisher","first-page":"e579","DOI":"10.1161\/CIR.0000000000000455","article-title":"Current diagnostic and treatment strategies for specific dilated cardiomyopathies: A scientific statement from the American heart association","volume":"134","author":"Bozkurt","year":"2016","journal-title":"Circulation"},{"key":"10.25259\/JCIS_126_2021\/ref-2","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1161\/CIRCRESAHA.117.309711","article-title":"Classification, epidemiology, and global burden of cardiomyopathies","volume":"121","author":"McKenna","year":"2017","journal-title":"Circ 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