{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T11:29:34Z","timestamp":1766402974736,"version":"3.48.0"},"reference-count":6,"publisher":"Scientific Scholar","content-domain":{"domain":["clinicalimagingscience.org"],"crossmark-restriction":true},"short-container-title":["JCIS"],"abstract":"<jats:p>\n                    Adamantinoma-like Ewing sarcoma (ALES) of the parotid gland is an exceptionally rare neoplasm. We report the case of a 57-year-old male with a history of p16-positive tonsillar squamous cell carcinoma who presented 2 years after remission with excessive mucus production and neck stiffness. Imaging identified a left parotid mass, and diagnosis was confirmed through surgical pathology, with molecular testing revealing a Fused in Sarcoma-Fifth Ewing Variant (\n                    <jats:italic>FUS-FEV)<\/jats:italic>\n                    fusion gene. Treatment included radical parotidectomy, adjuvant external beam radiation, and systemic chemotherapy following the Ewing sarcoma paradigm. Despite initial response, the patient experienced significant toxicities and eventually succumbed to disease-related complications. This case illustrates the challenges in diagnosing and managing rare parotid malignancies and highlights the importance of multidisciplinary care.\n                  <\/jats:p>","DOI":"10.25259\/jcis_142_2025","type":"journal-article","created":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T11:23:36Z","timestamp":1766402616000},"page":"47","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adamantinoma-like Ewing sarcoma of the parotid gland: A case report"],"prefix":"10.25259","volume":"15","author":[{"given":"Ayushi","family":"Vashishtha","sequence":"first","affiliation":[{"name":"Morsani College of Medicine, University of South Florida, Tampa, United States,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Interventional Radiology, Tampa, United States,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasanain","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, United States,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikesh J.","family":"Makanji","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging and Interventional Radiology, Tampa, United States,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"10.25259\/JCIS_142_2025\/ref-1","doi-asserted-by":"publisher","first-page":"e80477","DOI":"10.7759\/cureus.80477","article-title":"Adamantinoma-like Ewing sarcoma of the parotid gland: A systematic review","volume":"17","author":"Tsaprazlis","year":"2025","journal-title":"Cureus"},{"key":"10.25259\/JCIS_142_2025\/ref-2","doi-asserted-by":"publisher","first-page":"e11870","DOI":"10.7759\/cureus.11870","article-title":"Adamantinoma-like Ewing sarcoma of the parotid gland: Report of two cases and review of literature","volume":"12","author":"Alnuaim","year":"2020","journal-title":"Cureus"},{"key":"10.25259\/JCIS_142_2025\/ref-3","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1007\/s12105-014-0558-0","article-title":"Adamantinoma-like Ewing sarcoma mimicking basal cell adenocarcinoma of the parotid gland: A case report and review of the literature","volume":"9","author":"Lezcano","year":"2015","journal-title":"Head Neck Pathol"},{"key":"10.25259\/JCIS_142_2025\/ref-4","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/gcc.22828","article-title":"Ewing sarcoma with FEV gene rearrangements is a rare subset with predilection for extraskeletal locations and aggressive behavior","volume":"59","author":"Tsuda","year":"2020","journal-title":"Genes Chromosomes Cancer"},{"key":"10.25259\/JCIS_142_2025\/ref-5","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1177\/10668969221081029","article-title":"Outcome for neoadjuvant treatment of parotid gland adamantinoma-like Ewing sarcoma: Case report and review of literatures","volume":"30","author":"Wei","year":"2022","journal-title":"Int J Surg Pathol"},{"key":"10.25259\/JCIS_142_2025\/ref-6","doi-asserted-by":"publisher","first-page":"E38","DOI":"10.1002\/dc.25061","article-title":"Fine-needle aspiration cytology of adamantinoma-like Ewing sarcoma: An unusual parotid tumor","volume":"51","author":"Kakkar","year":"2023","journal-title":"Diagn Cytopathol"}],"container-title":["Journal of Clinical Imaging Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/clinicalimagingscience.org\/adamantinoma-like-ewing-sarcoma-of-the-parotid-gland-a-case-report\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/clinicalimagingscience.org\/adamantinoma-like-ewing-sarcoma-of-the-parotid-gland-a-case-report\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T11:23:36Z","timestamp":1766402616000},"score":1,"resource":{"primary":{"URL":"https:\/\/clinicalimagingscience.org\/adamantinoma-like-ewing-sarcoma-of-the-parotid-gland-a-case-report\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,18]]},"references-count":6,"alternative-id":["10.25259\/JCIS_142_2025"],"URL":"https:\/\/doi.org\/10.25259\/jcis_142_2025","relation":{},"ISSN":["2156-5597","2156-7514"],"issn-type":[{"type":"electronic","value":"2156-5597"},{"type":"print","value":"2156-7514"}],"subject":[],"published":{"date-parts":[[2025,12,18]]},"article-number":"47"}}