{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:55:48Z","timestamp":1782262548495,"version":"3.54.5"},"reference-count":29,"publisher":"Scientific Scholar","content-domain":{"domain":["clinicalimagingscience.org"],"crossmark-restriction":true},"short-container-title":["JCIS"],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Objectives:<\/jats:title>\n<jats:p>The aim of the study was to evaluate the accuracy of computed tomography\/magnetic resonance imaging (CT\/MRI) in characterizing cystic lesions of the pancreas and in differentiating between benign and malignant\/potentially malignant lesions.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Material and Methods:<\/jats:title>\n<jats:p>A retrospective study was performed on patients with pancreatic cystic lesions who underwent pre-operative imaging and surgery between October 2004 and April 2017 at a tertiary care teaching hospital. The images were reviewed for specific characteristics and diagnoses recorded independently by two radiologists who were blinded to the histopathological examination (HPE) report. Radiological diagnostic accuracy was assessed with HPE as reference standard.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results:<\/jats:title>\n<jats:p>A total of 80 patients fulfilled the inclusion criteria (M: F = 27:53). The final HPE diagnoses were solid pseudopapillary neoplasm (32.5%), walled off necrosis\/pseudocyst (27.5%), mucinous cystadenoma (15%), serous cystadenoma (11.25%), intraductal papillary mucinous neoplasm (8.75%), mucinous cystadenocarcinoma (2.5%), simple epithelial cyst (1.25%), and unspecified benign cystic lesion (1.25%). Observer1 correctly identified the diagnosis in 73.75% of cases while observer 2 did so in 72.5%. Sensitivity for distinguishing benign versus malignant\/potentially malignant lesions was 85.1% for observer 1 and 80.9% for observer 2. On multivariate logistic regression analysis: Solid cystic morphology, presence of mural nodule, and female gender were associated with premalignant\/malignant lesions.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Cross-sectional imaging is a valuable tool for characterization of pancreatic cystic lesions within its limitations.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/jcis_15_2020","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T09:34:59Z","timestamp":1589621699000},"page":"28","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Role of Cross-sectional Imaging (CT\/MRI) in Characterization and Distinguishing Benign from Malignant\/Potentially Malignant Cystic Lesions of Pancreas"],"prefix":"10.25259","volume":"10","author":[{"given":"Amy Sara","family":"Abraham","sequence":"first","affiliation":[{"name":"Departments of Radiodiagnosis, Christian Medical College and Hospital, Vellore, Tamil Nadu, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Simon","sequence":"additional","affiliation":[{"name":"Departments of Radiodiagnosis, Christian Medical College and Hospital, Vellore, Tamil Nadu, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Eapen","sequence":"additional","affiliation":[{"name":"Departments of Radiodiagnosis, Christian Medical College and Hospital, Vellore, Tamil Nadu, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirthi","family":"Sathyakumar","sequence":"additional","affiliation":[{"name":"Departments of Radiodiagnosis, Christian Medical College and Hospital, Vellore, Tamil Nadu, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuradha","family":"Chandramohan","sequence":"additional","affiliation":[{"name":"Departments of Radiodiagnosis, Christian Medical College and Hospital, Vellore, Tamil Nadu, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravish Sanghi","family":"Raju","sequence":"additional","affiliation":[{"name":"Departments of Hepatopancreaticobiliary Surgery, Christian Medical College and Hospital, Vellore, Tamil Nadu, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Joseph","sequence":"additional","affiliation":[{"name":"Departments of Hepatopancreaticobiliary Surgery, Christian Medical College and Hospital, Vellore, Tamil Nadu, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas Alex","family":"Kodiatte","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahasampath","family":"Gowri","sequence":"additional","affiliation":[{"name":"Biostatistics, Christian Medical College and Hospital, Vellore, Tamil Nadu, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,5,16]]},"reference":[{"key":"10.25259\/JCIS_15_2020\/ref-1","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1148\/rg.256045161","article-title":"Cystic pancreatic lesions: A simple imaging-based classification system for guiding management","volume":"25","author":"Sahani","year":"2005","journal-title":"Radiographics"},{"key":"10.25259\/JCIS_15_2020\/ref-2","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.2214\/AJR.05.0337","article-title":"Macrocystic neoplasms of the pancreas: CT differentiation of serous oligocystic adenoma from mucinous cystadenoma and intraductal papillary mucinous tumor","volume":"187","author":"Kim","year":"2006","journal-title":"AJR Am J Roentgenol"},{"key":"10.25259\/JCIS_15_2020\/ref-3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ejrad.2018.08.002","article-title":"The 'extracapsular cystic' sign in pancreatic serous cystic neoplasms: A clinicopathologic study of 177 patients with cystic pancreatic lesions","volume":"106","author":"Chen","year":"2018","journal-title":"Eur J Radiol"},{"key":"10.25259\/JCIS_15_2020\/ref-4","doi-asserted-by":"publisher","first-page":"648","DOI":"10.2214\/AJR.07.2365","article-title":"Characterization of cystic pancreatic masses: Relative accuracy of CT and MRI","volume":"189","author":"Visser","year":"2007","journal-title":"Am J Roentgenol"},{"key":"10.25259\/JCIS_15_2020\/ref-5","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1001\/archsurg.138.4.427","article-title":"Incidental pancreatic cysts: Clinicopathologic characteristics and comparison with symptomatic patients","volume":"138","author":"Castillo","year":"2003","journal-title":"Arch Surg"},{"key":"10.25259\/JCIS_15_2020\/ref-6","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1080\/j.1600-0455.2003.00111.x","article-title":"Intraductal papillary mucinous tumors of the pancreas. Comparison of helical CT and MR imaging","volume":"44","author":"Fukukura","year":"2003","journal-title":"Acta Radiol"},{"key":"10.25259\/JCIS_15_2020\/ref-7","doi-asserted-by":"publisher","first-page":"802","DOI":"10.2214\/AJR.07.3340","article-title":"Prevalence of unsuspected pancreatic cysts on MDCT","volume":"191","author":"Laffan","year":"2008","journal-title":"AJR Am J Roentgenol"},{"key":"10.25259\/JCIS_15_2020\/ref-8","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1038\/ajg.2010.122","article-title":"Prevalence of incidental pancreatic cysts in the adult population on MR imaging","volume":"105","author":"Lee","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.25259\/JCIS_15_2020\/ref-9","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1097\/00004728-199911000-00014","article-title":"Characterization of cystic tumors of the pancreas: CT accuracy","volume":"23","author":"Procacci","year":"1999","journal-title":"J Comput Assist Tomogr"},{"key":"10.25259\/JCIS_15_2020\/ref-10","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1080\/13651820802291225","article-title":"Accuracy of CT in predicting malignant potential of cystic pancreatic neoplasms","volume":"10","author":"Fisher","year":"2008","journal-title":"HPB (Oxford)"},{"key":"10.25259\/JCIS_15_2020\/ref-11","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.pan.2012.04.004","article-title":"International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas","volume":"12","author":"Tanaka","year":"2012","journal-title":"Pancreatology"},{"key":"10.25259\/JCIS_15_2020\/ref-12","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1177\/145749690509400213","article-title":"The Differentiation between pancreatic neoplastic cysts and pancreatic pseudocyst","volume":"94","author":"Sand","year":"2005","journal-title":"Scand J Surg"},{"key":"10.25259\/JCIS_15_2020\/ref-13","doi-asserted-by":"publisher","first-page":"297","DOI":"10.4103\/eus.eus_38_18","article-title":"Pancreatic cystic neoplasm diagnosis: Role of imaging","volume":"7","author":"Sarno","year":"2018","journal-title":"Endosc Ultrasound"},{"key":"10.25259\/JCIS_15_2020\/ref-14","first-page":"578","article-title":"The role of endoscopic ultrasound in cystic pancreatic tumor treatment","volume":"2","author":"Moparty","year":"2006","journal-title":"Gastroenterol Hepatol (NY)"},{"key":"10.25259\/JCIS_15_2020\/ref-15","doi-asserted-by":"publisher","first-page":"99","DOI":"10.2214\/ajr.175.1.1750099","article-title":"CT of primary cystic pancreatic neoplasms: Can CT be used for patient triage and treatment?","volume":"175","author":"Curry","year":"2000","journal-title":"AJR Am J Roentgenol"},{"key":"10.25259\/JCIS_15_2020\/ref-16","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.2214\/ajr.151.6.1133","article-title":"Cystic pancreatic tumors: CT and sonographic assessment","volume":"151","author":"Johnson","year":"1988","journal-title":"Am J Roentgenol"},{"key":"10.25259\/JCIS_15_2020\/ref-17","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1148\/radiol.2283020973","article-title":"Discrimination of unilocular macrocystic serous cystadenoma from pancreatic pseudocyst and mucinous cystadenoma with CT: Initial observations","volume":"228","author":"Cohen-Scali","year":"2003","journal-title":"Radiology"},{"key":"10.25259\/JCIS_15_2020\/ref-18","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1007\/s00330-014-3493-2","article-title":"Mucinous cystic neoplasms and serous cystadenomas arising in the body-tail of the pancreas: MR imaging characterization","volume":"25","author":"Manfredi","year":"2015","journal-title":"Eur Radiol"},{"key":"10.25259\/JCIS_15_2020\/ref-19","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1148\/rg.296095506","article-title":"MR imaging of cystic lesions of the pancreas","volume":"29","author":"Kalb","year":"2009","journal-title":"Radiographics"},{"key":"10.25259\/JCIS_15_2020\/ref-20","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1102\/1470-7330.2012.9054","article-title":"The incidental cystic pancreas mass: A practical approach","volume":"12","author":"Gore","year":"2012","journal-title":"Cancer Imaging"},{"key":"10.25259\/JCIS_15_2020\/ref-21","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1097\/01.sla.0000179651.21193.2c","article-title":"Serous cystadenoma of the pancreas: Tumor growth rates and recommendations for treatment","volume":"242","author":"Tseng","year":"2005","journal-title":"Ann Surg"},{"key":"10.25259\/JCIS_15_2020\/ref-22","doi-asserted-by":"publisher","first-page":"e1140","DOI":"10.1259\/bjr\/20695686","article-title":"Solid pseudopapillary tumours of the pancreas: Spectrum of imaging findings with histopathological correlation","volume":"85","author":"Sunkara","year":"2012","journal-title":"Br J Radiol"},{"key":"10.25259\/JCIS_15_2020\/ref-23","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1148\/radiology.199.3.8637992","article-title":"Solid and papillary epithelial neoplasm of the pancreas: Imaging-pathologic correlation on 56 cases","volume":"199","author":"Buetow","year":"1996","journal-title":"Radiology"},{"key":"10.25259\/JCIS_15_2020\/ref-24","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1007\/s00261-014-0138-5","article-title":"Cystic neoplasms of the pancreas; findings on magnetic resonance imaging with pathological, surgical, and clinical correlation","volume":"39","author":"Tirkes","year":"2014","journal-title":"Abdom Imaging"},{"key":"10.25259\/JCIS_15_2020\/ref-25","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/j.gie.2013.08.024","article-title":"Prevalence of malignancy in patients with pure main duct intraductal papillary mucinous neoplasms","volume":"79","author":"Abdeljawad","year":"2014","journal-title":"Gastrointest Endosc"},{"key":"10.25259\/JCIS_15_2020\/ref-26","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1097\/MPA.0000000000001182","article-title":"Imaging and cytopathological criteria indicating malignancy in mucin-producing pancreatic neoplasms: A series of 68 histopathologically confirmed cases","volume":"47","author":"Salla","year":"2018","journal-title":"Pancreas"},{"key":"10.25259\/JCIS_15_2020\/ref-27","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1001\/jamasurg.2016.3598","article-title":"Association of preoperative risk factors with malignancy in pancreatic mucinous cystic neoplasms: A multicenter study","volume":"152","author":"Postlewait","year":"2017","journal-title":"JAMA Surg"},{"key":"10.25259\/JCIS_15_2020\/ref-28","doi-asserted-by":"publisher","first-page":"4405","DOI":"10.3748\/wjg.v25.i31.4405","article-title":"Overview and comparison of guidelines for management of pancreatic cystic neoplasms","volume":"25","author":"Hasan","year":"2019","journal-title":"World J Gastroenterol"},{"key":"10.25259\/JCIS_15_2020\/ref-29","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/j.jacr.2017.03.010","article-title":"Management of incidental pancreatic cysts: A white paper of the ACR incidental findings committee","volume":"14","author":"Megibow","year":"2017","journal-title":"J Am Coll Radiol"}],"container-title":["Journal of Clinical Imaging Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/clinicalimagingscience.org\/role-of-cross-sectional-imaging-ct-mri-in-characterization-and-distinguishing-benign-from-malignant-potentially-malignant-cystic-lesions-of-pancreas\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/clinicalimagingscience.org\/role-of-cross-sectional-imaging-ct-mri-in-characterization-and-distinguishing-benign-from-malignant-potentially-malignant-cystic-lesions-of-pancreas\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T06:43:15Z","timestamp":1672728195000},"score":1,"resource":{"primary":{"URL":"https:\/\/clinicalimagingscience.org\/role-of-cross-sectional-imaging-ct-mri-in-characterization-and-distinguishing-benign-from-malignant-potentially-malignant-cystic-lesions-of-pancreas\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,16]]},"references-count":29,"alternative-id":["10.25259\/JCIS_15_2020"],"URL":"https:\/\/doi.org\/10.25259\/jcis_15_2020","relation":{},"ISSN":["2156-7514"],"issn-type":[{"value":"2156-7514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,16]]},"article-number":"28"}}