{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:32:49Z","timestamp":1783114369161,"version":"3.54.6"},"reference-count":44,"publisher":"Scientific Scholar","content-domain":{"domain":["clinicalimagingscience.org"],"crossmark-restriction":true},"short-container-title":["JCIS"],"abstract":"\nObjectives:<\/jats:title>\nThe objective of the study was to retrospectively investigate the safety and efficacy of computerized tomography-guided microwave ablation (MWA) in the treatment of Stage I non-small cell lung cancers (NSCLCs).<\/jats:p>\n<\/jats:sec>\n\nMaterial and Methods:<\/jats:title>\nThis retrospective, single-center study evaluated 21 patients (10 males and 11 females; mean age 73.8 \u00b1 8.2 years) with Stage I peripheral NSCLCs treated with MWA between 2010 and 2020. All patients were surveyed for metastatic disease. Clinical success was defined as absence of FDG avidity on follow-up imaging. Tumor growth within 5 mm of the original ablated territory was defined as local recurrence. Welch t<\/jats:italic>-test and Fisher\u2019s exact test were used for univariate analysis. Hazard ratio (HR) and odds ratio (OR) were determined using Cox regression and Firth logistic regression. Significance was P<\/jats:italic> < 0.05. Data are expressed as mean \u00b1 standard deviation.<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:title>\nAblated tumors had longest dimension 17.4 \u00b1 5.4 mm and depth 19.7 \u00b1 15.1 mm from the pleural surface. Median follow-up was 20 months (range, 0.6\u201356 months). Mean overall survival (OS) following lung cancer diagnosis or MWA was 26.2 \u00b1 15.4 months (range, 5\u201356 months) and 23.7 \u00b1 15.1 months (range, 3\u201355 months). OS at 1, 2, and 5 years was 67.6%, 61.8%, and 45.7%, respectively. Progression-free survival (PFS) was 19.1 \u00b1 16.2 months (range, 1\u201355 months). PFS at 1, 2, and 5 years was 44.5%, 32.9%, and 32.9%, respectively. Technical success was 100%, while clinical success was observed in 95.2% (20\/21) of patients. One patient had local residual disease following MWA and was treated with chemotherapy. Local control was 90% with recurrence in two patients following ablation. Six patients (28.6%) experienced post-ablation complications, with pneumothorax being the most common event (23.8% of patients). Female gender was associated with 90% reduction in risk of death (HR 0.1, P<\/jats:italic> = 0.014). Tumor longest dimension was associated with a 10% increase in risk of death (P<\/jats:italic> = 0.197). Several comorbidities were associated with increased hazard. Univariate analysis revealed pre-ablation forced vital capacity trended higher among survivors (84.7 \u00b1 15.2% vs. 73 \u00b1 21.6%, P<\/jats:italic> = 0.093). Adjusted for age and sex, adenocarcinoma, and neuroendocrine histology trended toward improved OS (OR: 0.13, 0.13) and PFS (OR: 0.88, 0.37) compared to squamous cell carcinoma.<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nMWA provides a safe and effective alternative to stereotactic brachytherapy resulting in promising OS and PFS in patients with Stage I peripheral NSCLC. Larger sample sizes are needed to further define the effects of underlying comorbidities and tumor biology.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/jcis_224_2020","type":"journal-article","created":{"date-parts":[[2021,2,9]],"date-time":"2021-02-09T03:50:43Z","timestamp":1612842643000},"page":"7","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Computerized tomography-Guided Microwave Ablation of Patients with Stage I Non-small Cell Lung Cancers: A Single-Institution Retrospective Study"],"prefix":"10.25259","volume":"11","author":[{"given":"Michael","family":"Nance","sequence":"first","affiliation":[{"name":"Department of Vascular and Interventional Radiology, School of Medicine, Columbia, Missouri, United States,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zain","family":"Khazi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Cardiothoracic Surgery, 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