{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:56:03Z","timestamp":1788429363959,"version":"build-2803163510"},"reference-count":15,"publisher":"Scientific Scholar","content-domain":{"domain":["clinicalimagingscience.org"],"crossmark-restriction":true},"short-container-title":["JCIS"],"abstract":"<jats:p>The medial longitudinal fasciculus (MLF) is a paired, highly specialized, and heavily myelinated nerve bundle responsible for extraocular muscle movements, including the oculomotor reflex, saccadic eye movements an smooth pursuit, and the vestibular ocular reflex. Clinically, lesions of the MLF are classically associated with internuclear ophthalmoplegia. However, clinical manifestations of a lesion in the MLF may be more complex and variable. We provide an overview of the neuroanatomy, neurologic manifestations, and correlative examples of the imaging findings on brain MRI of MLF lesions to provide the clinician and radiologist with a more comprehensive understanding of the MLF and potential clinical manifestations for an MLF lesion.<\/jats:p>","DOI":"10.25259\/jcis_49_2020","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:32:05Z","timestamp":1608251525000},"page":"83","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["An Anatomic, Imaging, and Clinical Review of the Medial Longitudinal Fasciculus"],"prefix":"10.25259","volume":"10","author":[{"given":"Peter","family":"Fiester","sequence":"first","affiliation":[{"name":"Department of Neuroradiology, University of Florida Health Jacksonville, Jacksonville, Florida, United States,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saif Ahmed","family":"Baig","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of Florida Health Jacksonville, Jacksonville, Florida, United States,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeet","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of Florida Health Jacksonville, Jacksonville, Florida, United States,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University of Florida Health Jacksonville, Jacksonville, Florida, United States,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,12,18]]},"reference":[{"key":"10.25259\/JCIS_49_2020\/ref-1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1148\/rg.331125033","article-title":"Brainstem pathways for horizontal eye movement: Pathologic correlation with MR imaging","volume":"33","author":"Bae","year":"2013","journal-title":"Radiographics"},{"key":"10.25259\/JCIS_49_2020\/ref-2","doi-asserted-by":"publisher","first-page":"e57","DOI":"10.1212\/01.wnl.0000310640.37810.b3","article-title":"Pearls and oy-sters: The medial longitudinal fasciculus in ocular motor physiology","volume":"70","author":"Frohman","year":"2008","journal-title":"Neurology"},{"key":"10.25259\/JCIS_49_2020\/ref-3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1097\/WNO.0b013e3180334e8d","article-title":"Wall-eyed bilateral internuclear ophthalmoplegia from lesions at different levels in the brainstem","volume":"27","author":"Chen","year":"2007","journal-title":"J Neuroophthalmol"},{"key":"10.25259\/JCIS_49_2020\/ref-4","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1212\/WNL.57.5.762","article-title":"MRI characteristics of the MLF in MS patients with chronic internuclear ophthalmoparesis","volume":"57","author":"Frohman","year":"2001","journal-title":"Neurology"},{"key":"10.25259\/JCIS_49_2020\/ref-5","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1001\/archneur.1978.00500320004002","article-title":"Internuclear ophthalmoplegia, I. 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