{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:55:10Z","timestamp":1794002110377,"version":"4.8.0"},"reference-count":45,"publisher":"Scientific Scholar","content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"\nObjective:<\/jats:title>\nThe aim of the study was to evaluate the association of the thickness of retinal nerve fiber layer (RNFL) with (i) visual symptoms and (ii) suprasellar extension defined by magnetic resonance imaging (MRI) in patients with pituitary macroadenoma.<\/jats:p>\n<\/jats:sec>\n\nMaterials and Methods:<\/jats:title>\nRNFL thickness of 50 consecutive patients operated for pituitary macroadenoma between July 2019 and April 2021 were compared with standard visual examination findings and MRI measurements such as optic chiasm height, distance between the optic chiasm and adenoma, suprasellar extension, and chiasmal lift.<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:title>\nThe study group included 100 eyes of 50 patients operated for pituitary adenomas with suprasellar extension. RNFL thinning predominantly involved the nasal (84.26 \u00b1 16.43 \u03bcm) and temporal quadrants (70.72 \u00b1 14.80 \u03bcm) and correlated well with the visual field deficit (P<\/jats:italic> < 0.001). Patients with moderate-to-severe deficit in visual acuity had a mean RNFL thickness <85 \u03bcm and patients with severe disc pallor had extremely thin RNFLs (<70 \u03bcm). Suprasellar extension defined as Wilsons Grade C, D, and E and Fujimotos Grades 3 and 4 were significantly associated with thin RNFLs <85 \u03bcm (P<\/jats:italic> < 0.01). Chiasmal lift more than 1 cm and tumor chiasm distance of <0.5 mm were associated with thin RNFL (P<\/jats:italic> < 0.002).<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nRNFL thinning correlates directly with the severity of visual deficits in patients with pituitary adenoma. Wilsons Grade D and E, Fujimoto Grade 3 and 4, chiasmal lift more than 1 cm, and chiasm tumor distance <0.5 mm are strong predictors of RNFL thinning and poor vision. Pituitary macro adenoma and other suprasellar tumors need to be excluded in patients with preserved vision but having obvious RNFL thinning.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/jnrp_18_2022","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T10:51:35Z","timestamp":1670583095000},"page":"41-47","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Retinal nerve fiber layer thickness and its correlation with visual symptoms and radiological features in pituitary macroadenoma"],"prefix":"10.25259","volume":"14","author":[{"given":"Sudha","family":"Menon","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Kasturba Medical College, Manipal Academy of Higher Education, Udupi, Karnataka, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, 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