{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T05:01:18Z","timestamp":1758862878608},"reference-count":11,"publisher":"Scientific Scholar","content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:p>S100B is a biochemical marker of head injury and optic nerve sheath diameter (ONSD) is a non-invasive bedside technique to detect intracranial pressure. We aim to demonstrate whether ONSD correlates with S100B protein in head injury patients with contusions and also whether the grade of contusion correlates with S100B protein. This is a prospective study done on head injury patients aged between 18 and 75 years having isolated contusions admitted within 24 h of injury. Patients were assessed neurologically with Glasgow Coma Scale (GCS) and cranial computed tomography study on admission. Ocular sonography was done for ONSD recording, and S100B protein venous samples were collected at 24 h, 48 h, and at discharge. The outcome was evaluated with Glasgow Outcome Scale (GOS) at discharge and 3 months. Out of 42 patients, the mean age was 46.2 years and 27 were males. There were 12 patients with mild, 25 with moderate, and 5 patients with severe head injury. The mean GCS at 24 h was 12.35, the mean ONSD at 24 h was 3.9 mm, and the mean S100B at 24 h was 0.214 \u00b5g\/L. There was a statistically significant correlation noted between mean S100B and contusion grade. A moderate positive correlation was noted between ONSD and S100B at 48 h in mild and moderate head injury groups. Favorable outcome (GOS 4,5) at 3 months can be predicted by GCS, contusion grade, and S100B values. Better GCS (14 and 15), focal contusion grade, and S100B values (&lt;0.5 \u00b5g\/L) predict good outcome. Although ONSD and S100B give important information in different scenarios, S100B gives better predictive information in patients with traumatic cerebral contusions.<\/jats:p>\n<jats:sec id=\"st5\">\n<jats:title>Key message:<\/jats:title>\n<jats:p>S100 B and ONSD are simple biochemical and radiological investigations that can be done in every neurosurgical setup and can be useful in the management of head injury patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/jnrp_45_2023","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T10:26:47Z","timestamp":1691404007000},"page":"599-602","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["S100B and optic nerve sheath diameter correlation in head injury patients with contusions"],"prefix":"10.25259","volume":"14","author":[{"given":"Amit Kumar","family":"Thotakura","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, NRI Academy of Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran Chand","family":"Velivela","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NRI Academy of Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nageswara Rao","family":"Marabathina","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NRI Academy of Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Aziz","family":"Riyaz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NRI Academy of Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siva Prabodh","family":"Vuddandi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, NRI Academy of Sciences, Guntur, Andhra Pradesh, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankamma Rao","family":"Danaboyina","sequence":"additional","affiliation":[{"name":"Department of Radiology, NRI Academy of Sciences, Guntur, Andhra Pradesh, India,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"10.25259\/JNRP_45_2023\/ref-1","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1089\/089771500415391","article-title":"Traumatic brain damage: Serum S-100 protein measurements related to neuroradiological findings","volume":"17","author":"Romner","year":"2000","journal-title":"J Neurotrauma"},{"key":"10.25259\/JNRP_45_2023\/ref-2","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/s007010050180","article-title":"Correlation of computed tomography findings and serum brain damage markers following severe head injury","volume":"140","author":"Raabe","year":"1998","journal-title":"Acta Neurochir (Wien)"},{"key":"10.25259\/JNRP_45_2023\/ref-3","doi-asserted-by":"publisher","first-page":"437","DOI":"10.3109\/02699059509008203","article-title":"The head injury severity scale (HISS): A practical classification of closed-head injury","volume":"9","author":"Stein","year":"1995","journal-title":"Brain Inj"},{"key":"10.25259\/JNRP_45_2023\/ref-4","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1227\/01.NEU.0000186013.63046.6B","article-title":"Prediction of outcome in traumatic brain injury with computed tomographic characteristics: A comparison between the computed tomographic classification and combinations of computed tomographic predictors","volume":"57","author":"Maas","year":"2005","journal-title":"Neurosurgery"},{"key":"10.25259\/JNRP_45_2023\/ref-5","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1089\/089771501300227297","article-title":"S-100 beta reflects the extent of injury and outcome, whereas neuronal specific enolase is a better indicator of neuroinflammation in patients with severe traumatic brain injury","volume":"18","author":"Pleines","year":"2001","journal-title":"J Neurotrauma"},{"key":"10.25259\/JNRP_45_2023\/ref-6","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1097\/01.shk.0000131193.80038.f1","article-title":"Changes in CSF S100B and cytokine concentrations in early-phase severe traumatic brain injury","volume":"22","author":"Hayakata","year":"2004","journal-title":"Shock"},{"key":"10.25259\/JNRP_45_2023\/ref-7","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s12028-013-9916-0","article-title":"Secondary peaks of S100B in serum relate to subsequent radiological pathology in traumatic brain injury","volume":"20","author":"Thelin","year":"2014","journal-title":"Neurocrit Care"},{"key":"10.25259\/JNRP_45_2023\/ref-8","doi-asserted-by":"publisher","first-page":"446","DOI":"10.3109\/02699052.2014.989403","article-title":"Association of ICP, CPP, CT findings and S-100B and NSE in severe traumatic head injury. Prognostic value of the biomarkers","volume":"29","author":"Olivecrona","year":"2015","journal-title":"Brain Inj"},{"key":"10.25259\/JNRP_45_2023\/ref-9","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/j.neuchi.2017.06.001","article-title":"Role of serial ultrasonic optic nerve sheath diameter monitoring in head injury patients","volume":"63","author":"Thotakura","year":"2017","journal-title":"Neurochirurgie"},{"key":"10.25259\/JNRP_45_2023\/ref-10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/10641955.2020.1849275","article-title":"Correlation between cerebral biomarkers and optic nerve sheath diameter in patients with severe preeclampsia","volume":"40","author":"Simenc","year":"2021","journal-title":"Hypertens Pregnancy"},{"key":"10.25259\/JNRP_45_2023\/ref-11","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1089\/neu.2013.3202","article-title":"Analysis of S100 calcium binding protein B serum levels in different types of traumatic intracranial lesions","volume":"32","author":"Wolf","year":"2015","journal-title":"J Neurotrauma"}],"container-title":["Journal of Neurosciences in Rural Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ruralneuropractice.com\/s100b-and-optic-nerve-sheath-diameter-correlation-in-head-injury-patients-with-contusions\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ruralneuropractice.com\/s100b-and-optic-nerve-sheath-diameter-correlation-in-head-injury-patients-with-contusions\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T09:08:05Z","timestamp":1699693685000},"score":1,"resource":{"primary":{"URL":"https:\/\/ruralneuropractice.com\/s100b-and-optic-nerve-sheath-diameter-correlation-in-head-injury-patients-with-contusions\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,7]]},"references-count":11,"alternative-id":["10.25259\/JNRP_45_2023"],"URL":"https:\/\/doi.org\/10.25259\/jnrp_45_2023","relation":{},"ISSN":["0976-3155","0976-3147"],"issn-type":[{"value":"0976-3155","type":"electronic"},{"value":"0976-3147","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8,7]]},"article-number":"599"}}