{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:52:03Z","timestamp":1780105923326,"version":"3.54.0"},"reference-count":11,"publisher":"Scientific Scholar","content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Objectives:<\/jats:title>\n<jats:p>Moyamoya disease (MMD) leads to frequent ischemic\/hemorrhagic manifestations. Our aim was to compare findings of arterial spin labeling (ASL) with dynamic susceptibility contrast (DSC) perfusion in patients of MMD<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Materials and Methods:<\/jats:title>\n<jats:p>Patients diagnosed as MMD underwent magnetic resonance imaging with ASL and DSC perfusion sequences. Perfusion in bilateral anterior cerebral artery and middle cerebral artery territories at two levels (level of thalami and centrum semiovale) was graded as normal (score 1), or reduced (score 2) on DSC and ASL cerebral blood flow (CBF) maps by comparison with normal cerebellar perfusion. Time to peak (TTP) maps of DSC perfusion were also qualitatively scored as normal (score 1), or increased (score 2) similarly. Correlation between scores of ASL, CBF, DSC, CBF, and DSC, TTP maps was assessed by using Spearman\u2019s rank correlation.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results:<\/jats:title>\n<jats:p>Among the 34 patients, we did not find any significant correlation between the ASL CBF maps and DSC CBF maps (r = \u22120.028, <jats:italic>P<\/jats:italic> = 0.878), mean matching index 0.39 \u00b1 0.31, whereas significant correlation was noted between the ASL CBF maps and DSC TTP maps (r = 0.58, <jats:italic>P<\/jats:italic> = 0.0003), mean matching index 0.79 \u00b1 0.26. ASL CBF underestimated the perfusion compared to DSC perfusion.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>ASL perfusion CBF maps do not match the DSC perfusion CBF maps and rather match the TTP maps of DSC perfusion. This is explained by inherent problems in estimation of CBF in these techniques because of delay in arrival of label (in ASL perfusion) or contrast bolus (in DSC perfusion) due to the presence of stenotic lesions.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/jnrp_58_2022","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T11:37:14Z","timestamp":1678448234000},"page":"286-292","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of arterial spin labeling perfusion with dynamic susceptibility contrast perfusion in Moyamoya disease"],"prefix":"10.25259","volume":"14","author":[{"given":"Nishtha","family":"Yadav","sequence":"first","affiliation":[{"name":"Department of Neuroradiology, Super Speciality Hospital, NSCB Medical College, Jabalpur, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hima","family":"Pendharkar","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging and Interventional Radiology, NIMHANS, Bengaluru, Karnataka, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun kumar","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging and Interventional Radiology, NIMHANS, Bengaluru, Karnataka, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrajit","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Neuroimaging and Interventional Radiology, NIMHANS, Bengaluru, Karnataka, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhaval","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NIMHANS, Bengaluru, Karnataka, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thennarasu","family":"Kandavel","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, NIMHANS, Bengaluru, Karnataka, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Neuroanaesthesia, NIMHANS, Bengaluru, Karnataka, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"10.25259\/JNRP_58_2022\/ref-1","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1001\/archneur.1969.00480090076012","article-title":"Cerebrovascular \u201cMoyamoya\u201d disease. Disease showing abnormal net-like vessels in base of brain","volume":"20","author":"Suzuki","year":"1969","journal-title":"Arch Neurol"},{"key":"10.25259\/JNRP_58_2022\/ref-2","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.nec.2017.02.004","article-title":"Direct versus indirect bypass for Moyamoya disease","volume":"28","author":"Liu","year":"2017","journal-title":"Neurosurg Clin"},{"key":"10.25259\/JNRP_58_2022\/ref-3","doi-asserted-by":"publisher","first-page":"2810","DOI":"10.1161\/hs1201.099893","article-title":"MR perfusion imaging in Moyamoya Syndrome: Potential implications for clinical evaluation of occlusive cerebrovascular disease","volume":"32","author":"Calamante","year":"2001","journal-title":"Stroke"},{"key":"10.25259\/JNRP_58_2022\/ref-4","doi-asserted-by":"publisher","first-page":"696","DOI":"10.3174\/ajnr.A5068","article-title":"Noninvasive evaluation of CBF and perfusion delay of Moyamoya disease using arterial spin-labeling MRI with multiple postlabeling delays: Comparison with 15O-gas PET and DSC-MRI","volume":"38","author":"Hara","year":"2017","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.25259\/JNRP_58_2022\/ref-5","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.nic.2011.02.007","article-title":"MR perfusion imaging in acute ischemic stroke","volume":"21","author":"Copen","year":"2011","journal-title":"Neuroimaging Clin N Am"},{"key":"10.25259\/JNRP_58_2022\/ref-6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1552-6569.2003.tb00152.x","article-title":"Susceptibility contrast and arterial spin labeled perfusion MRI in cerebrovascular disease","volume":"13","author":"Wolf","year":"2003","journal-title":"J Neuroimaging"},{"key":"10.25259\/JNRP_58_2022\/ref-7","doi-asserted-by":"publisher","first-page":"e87143","DOI":"10.1371\/journal.pone.0087143","article-title":"Clinical evaluation of an arterial-spin-labeling product sequence in stenoocclusive disease of the brain","volume":"9","author":"Mutke","year":"2014","journal-title":"PLoS One"},{"key":"10.25259\/JNRP_58_2022\/ref-8","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/1522-2594(200009)44:3<466::AID-MRM18>3.0.CO;2-M","article-title":"Delay and dispersion effects in dynamic susceptibility contrast MRI: Simulations using singular value decomposition","volume":"44","author":"Calamante","year":"2000","journal-title":"Magn Reson Med"},{"key":"10.25259\/JNRP_58_2022\/ref-9","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1097\/00004647-199907000-00001","article-title":"Measuring cerebral blood flow using magnetic resonance imaging techniques","volume":"19","author":"Calamante","year":"1999","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.25259\/JNRP_58_2022\/ref-10","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s00234-017-1969-x","article-title":"Transit time corrected arterial spin labeling technique aids to overcome delayed transit time effect","volume":"60","author":"Yun","year":"2018","journal-title":"Neuroradiology"},{"key":"10.25259\/JNRP_58_2022\/ref-11","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1161\/STROKEAHA.117.017773","article-title":"Long-delay arterial spin labeling provides more accurate cerebral blood flow measurements in Moyamoya patients: A simultaneous positron emission tomography\/MRI study","volume":"48","author":"Fan","year":"2017","journal-title":"Stroke"}],"container-title":["Journal of Neurosciences in Rural Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ruralneuropractice.com\/comparison-of-arterial-spin-labeling-perfusion-with-dynamic-susceptibility-contrast-perfusion-in-moyamoya-disease\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ruralneuropractice.com\/comparison-of-arterial-spin-labeling-perfusion-with-dynamic-susceptibility-contrast-perfusion-in-moyamoya-disease\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T11:46:07Z","timestamp":1683114367000},"score":1,"resource":{"primary":{"URL":"https:\/\/ruralneuropractice.com\/comparison-of-arterial-spin-labeling-perfusion-with-dynamic-susceptibility-contrast-perfusion-in-moyamoya-disease\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,10]]},"references-count":11,"alternative-id":["10.25259\/JNRP_58_2022"],"URL":"https:\/\/doi.org\/10.25259\/jnrp_58_2022","relation":{},"ISSN":["0976-3155","0976-3147"],"issn-type":[{"value":"0976-3155","type":"electronic"},{"value":"0976-3147","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3,10]]},"article-number":"286"}}