{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:27:44Z","timestamp":1783711664427,"version":"3.55.0"},"reference-count":5,"publisher":"Scientific Scholar","content-domain":{"domain":["ruralneuropractice.com"],"crossmark-restriction":true},"short-container-title":["JNRP"],"abstract":"<jats:p>Isolated area postrema syndrome (APS) is a rare neurological presentation of, neuromyelitis optica spectrums disorder (NMOSD), recognizable by uncontrollable hiccups, nausea, or vomiting. When it occurs as the first presentation of NMOSD, it may present as a diagnostic challenge as the condition may be frequently attributed to gastrointestinal pathology, and the subsequent diagnostic delay may result in debilitating neurological sequelae such as optic neuritis or myelitis. We report such a case of isolated APS in a young woman who presented with a clinical picture of bouts of vomiting and intractable hiccups causing considerable distress and was finally diagnosed to be a case of seronegative NMOSD.<\/jats:p>","DOI":"10.25259\/jnrp_83_2022","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T12:30:29Z","timestamp":1679315429000},"page":"361-362","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Area postrema syndrome: An unusual presentation of neuromyelitis optica spectrum disorder"],"prefix":"10.25259","volume":"14","author":[{"given":"Aiswarya","family":"Raj","sequence":"first","affiliation":[{"name":"Department of Neurology, Aster MIMS Hospital, Kozhikode, Kerala, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf V.","family":"Valappil","sequence":"additional","affiliation":[{"name":"Department of Neurology, Aster MIMS Hospital, Kozhikode, Kerala, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Alapatt","sequence":"additional","affiliation":[{"name":"Department of Neurology, Aster MIMS Hospital, Kozhikode, Kerala, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jubin","family":"Kamar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Aster MIMS Hospital, Kozhikode, Kerala, India,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"10.25259\/JNRP_83_2022\/ref-1","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1212\/WNL.0000000000001729","article-title":"International consensus diagnostic criteria for neuromyelitis optica spectrum disorders","volume":"85","author":"Wingerchuk","year":"2015","journal-title":"Neurology"},{"key":"10.25259\/JNRP_83_2022\/ref-2","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1177\/1352458518813105","article-title":"Area postrema syndrome: A short history of a pearl in demyelinating disease","volume":"25","author":"Camara-Lemarroy","year":"2019","journal-title":"Mult Scler J"},{"key":"10.25259\/JNRP_83_2022\/ref-3","doi-asserted-by":"publisher","first-page":"e238588","DOI":"10.1136\/bcr-2020-238588","article-title":"Area postrema syndrome: A neurological presentation of nausea, vomiting, and hiccups","volume":"13","author":"Chan","year":"2020","journal-title":"BMJ Case Rep"},{"key":"10.25259\/JNRP_83_2022\/ref-4","doi-asserted-by":"publisher","first-page":"e1642","DOI":"10.1212\/WNL.0000000000006392","article-title":"Area postrema syndrome: Frequency, criteria, and severity in AQP4-IgG-positive NMOSD","volume":"91","author":"Shosha","year":"2018","journal-title":"Neurology"},{"key":"10.25259\/JNRP_83_2022\/ref-5","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.cgh.2012.11.021","article-title":"Intractable nausea and vomiting from autoantibodies against a brain water channel","volume":"11","author":"Iorio","year":"2013","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["Journal of Neurosciences in Rural Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ruralneuropractice.com\/area-postrema-syndrome-an-unusual-presentation-of-neuromyelitis-optica-spectrum-disorder\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ruralneuropractice.com\/area-postrema-syndrome-an-unusual-presentation-of-neuromyelitis-optica-spectrum-disorder\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T11:39:50Z","timestamp":1683113990000},"score":1,"resource":{"primary":{"URL":"https:\/\/ruralneuropractice.com\/area-postrema-syndrome-an-unusual-presentation-of-neuromyelitis-optica-spectrum-disorder\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,16]]},"references-count":5,"alternative-id":["10.25259\/JNRP_83_2022"],"URL":"https:\/\/doi.org\/10.25259\/jnrp_83_2022","relation":{},"ISSN":["0976-3155","0976-3147"],"issn-type":[{"value":"0976-3155","type":"electronic"},{"value":"0976-3147","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3,16]]},"article-number":"361"}}