{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T05:01:41Z","timestamp":1667451701886},"reference-count":20,"publisher":"Scientific Scholar","content-domain":{"domain":["nmji.in"],"crossmark-restriction":true},"short-container-title":["NMJI"],"abstract":"\nBackground<\/jats:title>\nThe western recommendations for the use of organs from liver donors with tuberculosis (TB) come from an environment where the burden of disease is low and cadaveric organ donation rates are high\u2014in complete contrast to the Indian scenario, where these recommendations may be too restrictive.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nA questionnaire relating to current practice on the use of organs from liver donors with TB was sent to all liver transplant centres in India.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nResponses were obtained from 94% of centres. Two-thirds accepted organs from deceased donors with TB in the elective setting, especially for recipients with a high MELD (Model for end-stage liver disease) score. The proportion rose by 1.5 times in the setting of acute liver failure. Two-thirds advised anti-TB treatment (ATT) for corresponding recipients, and the remaining advised isonicotinic acid hydrazide (INH) prophylaxis. Untreated living donors with TB were not accepted. Half the respondents accepted living donors after completion of ATT, and did not treat recipients postoperatively. The remainder accepted them after 8 weeks of treatment and advised INH prophylaxis or ATT for recipients.<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nThat this practice has not impacted recipient outcomes suggests that the guidelines for management of liver donors and recipients may need to be altered for populations endemic for TB.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/nmji_419_19","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T02:51:11Z","timestamp":1667357471000},"page":"82-87","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The potential liver donor with tuberculosis: A fresh look at international recommendations based on a survey of practice in Indian liver transplant centres"],"prefix":"10.25259","volume":"35","author":[{"given":"SANJAY","family":"GOVIL","sequence":"first","affiliation":[{"name":"Apollo Integrated Liver Care, Apollo Hospital, 154\/11 Bannerghatta Road, Bengaluru 560076, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SANDEEP","family":"SATSANGI","sequence":"additional","affiliation":[{"name":"Apollo Integrated Liver Care, Apollo Hospital, 154\/11 Bannerghatta Road, Bengaluru 560076, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAYANTH","family":"REDDY","sequence":"additional","affiliation":[{"name":"Apollo Integrated Liver Care, Apollo Hospital, 154\/11 Bannerghatta Road, Bengaluru 560076, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SURESH","family":"RAGHAVAIAH","sequence":"additional","affiliation":[{"name":"Apollo Integrated Liver Care, Apollo Hospital, 154\/11 Bannerghatta Road, Bengaluru 560076, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SUBRAMANIAN","family":"SWAMINATHAN","sequence":"additional","affiliation":[{"name":"Gleneagles Global Health City, Chennai, Tamil 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