{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:51:33Z","timestamp":1781866293562,"version":"3.54.5"},"reference-count":27,"publisher":"Scientific Scholar","content-domain":{"domain":["nmji.in"],"crossmark-restriction":true},"short-container-title":["NMJI"],"abstract":"<jats:sec id=\"st1\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diabetic foot ulcers are an important problem for people with diabetes mellitus. We aimed to determine the mortality rate in patients with diabetic foot ulcers and assess the relationship between mortality, the Wagner classification of diabetic foot, and biochemical parameters, such as glucose, haemoglobin A1c (HbA1c), and lipid profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included patients with diabetic foot ulcers treated at a training and research hospital from April 2019 to June 2022. We compared patients who died during this period and those who were alive to determine the mortality rate and assess predictive factors for mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We included 170 patients in the study; their mortality rate was 29.4%. The Wagner classification did not reveal a statistically significant difference in mortality (p=0.334). However, a statistically significant association was found between mortality and the duration of diabetes (p=0.036), uric acid levels and creatinine values (p&lt;0.05). Although the median HbA1c levels were higher in those who were alive compared with the deceased, this did not affect mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st4\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The Wagner classification for diabetic foot ulcers did not show any correlation with mortality. Instead, blood glucose, creatinine, and aspartate aminotransferase values predicted mortality in people with diabetic foot.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.25259\/nmji_536_2024","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:47:43Z","timestamp":1780303663000},"page":"235-238","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mortality among patients with diabetic foot ulcers and its relationship with Wagner classification and glucose regulation"],"prefix":"10.25259","volume":"39","author":[{"given":"ELIF","family":"D\u00dcS\u00dcNEN","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Caldiran State Hospital, Van, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EGEMEN","family":"TURAL","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Cifteler State Hospital, Eskisehir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ASLI KARADENIZ","family":"YONAK","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, SBU Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AKIN","family":"DAYAN","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, SBU Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"10.25259\/NMJI_536_2024\/ref-1","first-page":"205","article-title":"Diabetic foot problems","volume":"205","author":"TEMD Diabetes Mellitus Study and Training Group","year":"2022","journal-title":"TEMD Diabetes Mellitus and Complications Diagnosis, Treatment and Monitoring Guide"},{"key":"10.25259\/NMJI_536_2024\/ref-2","doi-asserted-by":"publisher","first-page":"S8","DOI":"10.1016\/j.jcjd.2013.01.011","article-title":"Definition, classification and diagnosis of diabetes, prediabetes and metabolic syndrome","volume":"37","author":"Goldenberg","year":"2013","journal-title":"Can J Diabetes"},{"key":"10.25259\/NMJI_536_2024\/ref-3","doi-asserted-by":"publisher","first-page":"62","DOI":"10.5312\/wjo.v6.i1.62","article-title":"Diabetic foot syndrome: Immune-inflammatory features as possible cardiovascular markers in diabetes","volume":"6","author":"Tuttolomondo","year":"2015","journal-title":"World J Orthop"},{"key":"10.25259\/NMJI_536_2024\/ref-4","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1016\/j.jvs.2014.04.052","article-title":"Influence of foot ulceration on cause-specific mortality in patients with diabetes mellitus","volume":"60","author":"Brownrigg","year":"2014","journal-title":"J Vasc Surg"},{"key":"10.25259\/NMJI_536_2024\/ref-5","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.jdiacomp.2014.04.011","article-title":"The independent contribution of diabetic foot ulcer on lower extremity amputation and mortality risk","volume":"28","author":"Martins-Mendes","year":"2014","journal-title":"J Diabetes Complications"},{"key":"10.25259\/NMJI_536_2024\/ref-6","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1111\/dme.13054","article-title":"Association of diabetic foot ulcer and death in a population-based cohort from the United Kingdom","volume":"33","author":"Walsh","year":"2016","journal-title":"Diabet Med"},{"key":"10.25259\/NMJI_536_2024\/ref-7","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.2337\/dc12-0200","article-title":"Long-term prognosis of diabetic foot patients and their limbs: Amputation and death over the course of a decade","volume":"35","author":"Morbach","year":"2012","journal-title":"Diabetes Care"},{"key":"10.25259\/NMJI_536_2024\/ref-8","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.2337\/dc07-2145","article-title":"Long-term outcome and disability of diabetic patients hospitalized for diabetic foot ulcers: A 6.5-year follow-up study","volume":"31","author":"Ghanassia","year":"2008","journal-title":"Diabetes Care"},{"key":"10.25259\/NMJI_536_2024\/ref-9","doi-asserted-by":"publisher","first-page":"491","DOI":"10.2337\/diacare.26.11.3200","article-title":"Amputation and mortality in new-onset diabetic foot ulcers stratified by etiology","volume":"26","author":"Moulik","year":"2003","journal-title":"Diabetes Care"},{"key":"10.25259\/NMJI_536_2024\/ref-10","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.jdiacomp.2016.11.020","article-title":"Diabetic foot ulcer severity predicts mortality among veterans with type 2 diabetes","volume":"31","author":"Brennan","year":"2017","journal-title":"J Diabetes Complications"},{"key":"10.25259\/NMJI_536_2024\/ref-11","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.2337\/dc09-0651","article-title":"History of foot ulcer increases mortality among individuals with diabetes: Ten-year follow-up of the Nord-Tr\u00f8ndelag Health Study, Norway","volume":"32","author":"Iversen","year":"2009","journal-title":"Diabetes Care"},{"key":"10.25259\/NMJI_536_2024\/ref-12","first-page":"127","article-title":"The influence of gender as a risk factor in diabetic foot ulceration","volume":"20","author":"Dinh","year":"2008","journal-title":"Wounds"},{"key":"10.25259\/NMJI_536_2024\/ref-13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12902-018-0327-2","article-title":"Mortality in patients with diabetic foot ulcer: A retrospective study of 513 cases from a single centre in the Northern Territory of Australia","volume":"19","author":"Jeyaraman","year":"2019","journal-title":"BMC Endocr Disord"},{"key":"10.25259\/NMJI_536_2024\/ref-14","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.diabet.2019.04.010","article-title":"Five-year mortality in patients with diabetic foot ulcer during 2009-2010 was lower than expected","volume":"46","author":"Amadou","year":"2020","journal-title":"Diabetes Metab"},{"key":"10.25259\/NMJI_536_2024\/ref-15","first-page":"117","article-title":"Diabetes Mellitus'ta mikrovask\u00fcler komplikasyonlarin y\u00f6netimi [Management of microvascular complications in diabetes mellitus]","volume":"7","author":"\u00d6nmez","year":"2017","journal-title":"J DU Health Sci Inst"},{"key":"10.25259\/NMJI_536_2024\/ref-16","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.3390\/jcm9093009","article-title":"Mortality in patients with diabetic foot ulcers: Causes, risk factors, and their association with evolution and severity of ulcer","volume":"9","author":"Rubio","year":"2020","journal-title":"J Clin Med"},{"key":"10.25259\/NMJI_536_2024\/ref-17","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.jdiacomp.2007.09.004","article-title":"Risk factors associated with adverse outcomes in a population-based prospective cohort study of people with their first diabetic foot ulcer","volume":"21","author":"Winkley","year":"2007","journal-title":"J Diabetes Complications"},{"key":"10.25259\/NMJI_536_2024\/ref-18","doi-asserted-by":"publisher","first-page":"409","DOI":"10.2337\/dc11-0996","article-title":"The impact of frequent and unrecognized hypoglycemia on mortality in the ACCORD study","volume":"35","author":"Seaquist","year":"2012","journal-title":"Diabetes Care"},{"key":"10.25259\/NMJI_536_2024\/ref-19","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.2337\/dc07-2244","article-title":"Association between renal failure and foot ulcer or lower-extremity amputation in patients with diabetes","volume":"31","author":"Margolis","year":"2008","journal-title":"Diabetes Care"},{"key":"10.25259\/NMJI_536_2024\/ref-20","doi-asserted-by":"publisher","first-page":"4949","DOI":"10.1210\/jc.2019-00286","article-title":"Disturbances in insulin-glucose metabolism in patients with advanced renal disease with and without diabetes","volume":"104","author":"Rahhal","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"10.25259\/NMJI_536_2024\/ref-21","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.2147\/DMSO.S423017","article-title":"The ratio of serum uric acid to glycosylated haemoglobin as a predictor of all-mortality in elderly patients with diabetic foot ulcers: A longitudinal cohort study","volume":"16","author":"Huang","year":"2023","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.25259\/NMJI_536_2024\/ref-22","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.diabres.2012.04.012","article-title":"Coronary calcium score, albuminuria and inflammatory markers in type 2 diabetic patients: Associations and prognostic implications","volume":"98","author":"Dayan","year":"2012","journal-title":"Diabetes Res Clin Pract"},{"key":"10.25259\/NMJI_536_2024\/ref-23","doi-asserted-by":"publisher","first-page":"569","DOI":"10.3109\/00365513.2013.821712","article-title":"Serum creatinine is associated with coronary disease risk even in the absence of metabolic disorders","volume":"73","author":"Onat","year":"2013","journal-title":"Scand J Clin Lab Invest"},{"key":"10.25259\/NMJI_536_2024\/ref-24","doi-asserted-by":"publisher","first-page":"154","DOI":"10.5455\/medarh.2019.73.154-156","article-title":"Serum creatinine and occurrence and severity of coronary artery disease","volume":"73","author":"Bagheri","year":"2019","journal-title":"Med Arch"},{"key":"10.25259\/NMJI_536_2024\/ref-25","doi-asserted-by":"publisher","first-page":"248","DOI":"10.5350\/SEMB.20150903125636","article-title":"Relationship of blood lipid levels with HbA1c and obesity in patients with type 2 diabetes mellitus","volume":"49","author":"\u00d6zdo\u00f0an","year":"2015","journal-title":"Med Bull Sisli Etfal Hosp"},{"key":"10.25259\/NMJI_536_2024\/ref-26","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s10238-007-0121-3","article-title":"Association between glycaemic control and serum lipids profile in type 2 diabetic patients: HbA1c predicts dyslipidaemia","volume":"7","author":"Khan","year":"2007","journal-title":"Clin Exp Med"},{"key":"10.25259\/NMJI_536_2024\/ref-27","doi-asserted-by":"publisher","first-page":"115","DOI":"10.2337\/diaclin.23.3.115","article-title":"Elevated liver function tests in type 2 diabetes","volume":"23","author":"Harris","year":"2005","journal-title":"Clin Diabetes"}],"container-title":["The National Medical Journal of India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/nmji.in\/mortality-among-patients-with-diabetic-foot-ulcers-and-its-relationship-with-wagner-classification-and-glucose-regulation\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/nmji.in\/mortality-among-patients-with-diabetic-foot-ulcers-and-its-relationship-with-wagner-classification-and-glucose-regulation\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T09:59:32Z","timestamp":1781863172000},"score":1,"resource":{"primary":{"URL":"https:\/\/nmji.in\/mortality-among-patients-with-diabetic-foot-ulcers-and-its-relationship-with-wagner-classification-and-glucose-regulation\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":27,"alternative-id":["10.25259\/NMJI_536_2024"],"URL":"https:\/\/doi.org\/10.25259\/nmji_536_2024","relation":{},"ISSN":["2583-150X","0970-258X"],"issn-type":[{"value":"2583-150X","type":"electronic"},{"value":"0970-258X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"article-number":"235"}}