{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T11:10:09Z","timestamp":1744888209605,"version":"3.40.4"},"reference-count":7,"publisher":"Scientific Scholar","content-domain":{"domain":["nmji.in"],"crossmark-restriction":true},"short-container-title":["NMJI"],"abstract":"<jats:p>Myeloproliferative neoplasms (MPNs) can be classified into two major categories, namely chronic myeloid leukaemia (CML) and Philadelphia-negative MPNs (PN-MPNs). BCR\u2013 ABL1 reassortment is an irreplaceable indicator for the diagnosis of typical CML, while the V617F mutation on the Janus kinase 2 (JAK2) gene is common in PN-MPNs patients. Generally, these two genetic abnormalities are considered unable to coexist. We report a patient with CML who had both genetic changes, suggesting that when tyrosine kinase inhibitors (TKIs) monotherapy cannot obtain satisfactory treatment outcomes in CML patients, another possibility besides disease progression is a mutation on the JAK2 V617F gene.<\/jats:p>","DOI":"10.25259\/nmji_61_2022","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T10:42:05Z","timestamp":1744886525000},"page":"325-326","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coexistence of BCR\u2013ABL1 reassortment and JAK2 V617F mutation in chronic myeloid leukaemia"],"prefix":"10.25259","volume":"37","author":[{"given":"JIANJUN YANG","family":"CHEELOO","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, College of Medicine, Shandong University, No. 44 Cultural West Road, Lixia district, Jinan-250012, Shandong province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KEHONG","family":"BI","sequence":"additional","affiliation":[{"name":"Department of Haematology, The First Affiliated Hospital of Shandong First Medical University, No. 16766 Jingshi Road, Wendong Street, Lixia District, Jinan 250014, Shandong province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ZHAOGUANG","family":"ZHANG","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, College of Medicine, Shandong University, No. 44 Cultural West Road, Lixia district, Jinan-250012, Shandong province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"10.25259\/NMJI_61_2022\/ref-1","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41408-018-0054-y","article-title":"The 2016 WHO classification and diagnostic criteria for myeloproliferative neoplasms: Document summary 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