{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T05:15:42Z","timestamp":1739337342350,"version":"3.37.0"},"reference-count":23,"publisher":"Scientific Scholar","content-domain":{"domain":["nmji.in"],"crossmark-restriction":true},"short-container-title":["NMJI"],"abstract":"<jats:p>Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by increased production of fibroblast growth factor 23 (FGF-23). A 45-year-old man presented to us with progressive weakness over 2 years along with recurrent fractures with minimal trauma. His FGF-23 was found to be above the normal range and DOTATATE positron emission tomography (PET) scan showed a well-defined enhancing soft tissue density involving the left posterior ethmoid with extension to the spheno-ethmoidal recess and sphenoid sinus ostium. He underwent endoscopic sinus surgery and excision of the tumour. Histopathological examination showed features of phosphaturic mesenchymal tumour\u2013mixed connective tissue type. Postoperatively the serum phosphorus level increased from day 1 and reached the normal value of 2.5 mg\/dl on day 3. He was discharged and continued on oral calcium and vitamin D3. Gradually his myalgia improved and he started walking independently over the next 1 month. The mean delay from symptom onset to treatment in our patient was 2 years and 5 months. Timely diagnosis and meticulous follow-up are necessary for the management of patients with this rare disorder.<\/jats:p>","DOI":"10.25259\/nmji_639_21","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T06:42:23Z","timestamp":1739256143000},"page":"253-256","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tumour-induced osteomalacia"],"prefix":"10.25259","volume":"37","author":[{"given":"ATHIRA","family":"RAMAKRISHANAN","sequence":"first","affiliation":[{"name":"Department of Head and Neck Surgical Oncology, Fortis Hospital, Bannerghatta Road, Bengaluru 560076, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AASHISH","family":"PAREKH","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Fortis Hospital, Bannerghatta Road, Bengaluru 560076, Karnataka, 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