{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T08:18:04Z","timestamp":1768465084711,"version":"3.49.0"},"reference-count":11,"publisher":"Scientific Scholar","content-domain":{"domain":["nmji.in"],"crossmark-restriction":true},"short-container-title":["NMJI"],"abstract":"\n Background<\/jats:title>\n Chronic kidney disease (CKD) is associated with accelerated cardiovascular (CV) risk, particularly due to subclinical atherosclerosis. Carotid intima\u2013media thickness (CIMT) is a non-invasive marker of early athero-sclerotic changes. Altered mineral metabolism in CKD, also known as CKD\u2013mineral bone disorder (CKD-MBD), may contribute to vascular damage. We evaluated the association between CIMT and mineral metabolism markers in people with diabetes who had pre-dialysis CKD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A cross-sectional observational study was done in 110 adults with diabetes and pre-dialysis CKD. Biochemical markers including serum phosphate, intact parathyroid hormone (iPTH), fibroblast growth factor (FGF)-23, and 24-hour urinary phosphate were analyzed. CIMT was measured using B-mode ultrasonography. Correlation and regression analyses were performed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n CIMT showed significant positive correlations with serum phosphate, FGF-23, iPTH, and serum creatinine, and negative correlations with nephron index and urinary phosphate excretion. Serum phosphate >6 mg\/dl strongly predicted CIMT >0.9 mm.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Mineral metabolism markers, particularly serum phosphate and FGF-23, are significantly associated with subclinical atherosclerosis in CKD. Monitoring these parameters may aid in assessment of early CV risk in patients with CKD.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/nmji_827_2022","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T11:10:10Z","timestamp":1766747410000},"page":"13-18","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of carotid artery intima\u2013media thickness with parameters of mineral bone disorder in patients with chronic kidney disease"],"prefix":"10.25259","volume":"39","author":[{"given":"ADHIP","family":"ARORA","sequence":"first","affiliation":[{"name":"Department of Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RASHMI","family":"CHAUDHARY","sequence":"additional","affiliation":[{"name":"Department of Medicine, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SAHIL","family":"ARORA","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RAISA","family":"ARORA","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Employees State Insurance (ESI) Hospital, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"10.25259\/NMJI_827_2022\/ref-1","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1161\/01.ATV.11.5.1245","article-title":"Ultrasonographically assessed carotid morphology and the risk of coronary heart disease","volume":"11","author":"Salonen","year":"1991","journal-title":"Arterioscler 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