{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:51:29Z","timestamp":1791546689726,"version":"4.3.4"},"reference-count":19,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground:<\/jats:title>\nThe role of tractography in gamma ventral capsulotomy (GVC) planning is still unclear. This paper aims to describe the spatial distribution of medial orbitofrontal cortex (OFC) and lateral OFC fibers passing through the anterior limb of the internal capsule (ALIC) and analyze quantitative tractography parameters that differentiate obsessive-compulsive disorder (OCD) individuals from other neurosurgery functional patients (morbid obesity and Parkinson\u2019s disease [PD]).<\/jats:p>\n<\/jats:sec>\n\nMethods:<\/jats:title>\nTwenty patients undergoing functional stereotactic procedures, between 2013 and 2016, were included in this study. OCD patients underwent GVC (single shot 150 Gy and 4-mm collimators). PD and morbid obesity patients were submitted to deep brain stimulation implants. Diffusion tensor image tractography was reconstructed using Brainlab Elements software (Brainlab AG, Munich, Germany).<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:title>\nNine PD, six morbid obesity, and five OCD patients were included with a mean age of 65.4 \u00b1 9.1, 41.0 \u00b1 8.2, and 31.2 \u00b1 5.5, respectively, which are statistically different from each other (P<\/jats:italic> < 0.001). Fourteen patients (70%) were men. A total of 40 cerebral hemispheres were analyzed. Medial OFC fibers are localized more inferior in the ALIC than the lateral OFC fibers in all hemispheres, but the level of intersection and exact topography of fiber bundles are variable among individuals. Both medial and lateral OFC fiber tracts of PD and morbid obesity patients have lower volume than, respectively, medial and lateral counterparts of OCD patients (P<\/jats:italic> < 0.001).<\/jats:p>\n<\/jats:sec>\n\nConclusions:<\/jats:title>\nMedial and lateral OFC tract fibers have a general standard distribution in the anterior internal capsule (lateral OFC higher than medial OFC fibers). There are differences between obesity, Parkinson, and OCD patients regarding fiber tract statistics.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni-65-2019","type":"journal-article","created":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T07:46:19Z","timestamp":1566719179000},"page":"136","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Understanding gamma ventral capsulotomy: Potential implications of diffusion tensor image tractography on target selectivity"],"prefix":"10.25259","volume":"10","author":[{"given":"Bruno Fernandes de Oliveira","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and Radiotherapy, Hospital do Coracao (HCOR Neurosciences), Gamma Knife,"},{"name":"Departament of Psychiatry, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Gorgulho","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Radiotherapy, Hospital do Coracao (HCOR Neurosciences), Gamma Knife,"},{"name":"Departament of Psychiatry, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystian W. C.","family":"Saraiva","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Radiotherapy, Hospital do Coracao (HCOR Neurosciences), Gamma Knife,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Carlos","family":"Lopes","sequence":"additional","affiliation":[{"name":"Departament of Psychiatry, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Gabriel Ribeiro","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Radiotherapy, Hospital do Coracao (HCOR Neurosciences), Gamma Knife,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson M.","family":"P\u00e1ssaro","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and Radiotherapy, Hospital do Coracao (HCOR Neurosciences), Gamma Knife,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Q.","family":"Hoexter","sequence":"additional","affiliation":[{"name":"Departament of Psychiatry, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eur\u00edpedes C.","family":"Miguel","sequence":"additional","affiliation":[{"name":"Departament of Psychiatry, Faculty of Medicine, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio A. 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