{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T07:29:27Z","timestamp":1781162967203,"version":"3.54.1"},"reference-count":13,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Our study shows that a membrane sealant\/fiber fusogen polyethylene glycol (PEG) applied immediately on a sharp section of the spinal cord can mend the cord and lead to exceptional levels of motor recovery, with some animals almost normal.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Materials and Methods: <\/jats:title>\n<jats:p>Before deploying such technology in man, long-term data in large mammals that exclude delayed complications (e.g., central pain), confirm the stability of motor recovery, and provide histological evidence of fiber regrowth are necessary. Here, we provide such evidence in dogs followed up over 6 months and in 2 cases up to 1 year along with imaging and histologic data.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results: <\/jats:title>\n<jats:p>We show that dogs whose dorsal cord has been fully transected recover locomotion after immediate treatment with a fusogen (PEG). No pain syndrome ensued over the long term. Diffusion tensor imaging magnetic resonance and histological, including immunohistochemical, data confirmed the re-establishment of anatomical continuity along with interfacial axonal sprouting.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusions: <\/jats:title>\n<jats:p>This study proves that a form of irreversible spinal cord injury (SCI) can effectively be treated and points out a way to treat SCI patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni-73-2019","type":"journal-article","created":{"date-parts":[[2019,4,13]],"date-time":"2019-04-13T10:26:51Z","timestamp":1555151211000},"page":"50","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Reconstruction of the spinal cord of spinal transected dogs with polyethylene glycol"],"prefix":"10.25259","volume":"10","author":[{"given":"Shuai","family":"Ren","sequence":"first","affiliation":[{"name":"Hand and Microsurgery Center, The Second Affiliated Hospital of Harbin Medical University, Nangang, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zehan","family":"Liu","sequence":"additional","affiliation":[{"name":"Hand and Microsurgery Center, The Second Affiliated Hospital of Harbin Medical University, Nangang, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Yoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul 10100, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuang","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of MR Diagnosis, The Second Affiliated Hospital of Harbin Medical University, Nangang, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of MR Diagnosis, The Second Affiliated Hospital of Harbin Medical University, Nangang, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, The Second Affiliated Hospital of Harbin Medical University, Nangang, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Harbin Medical University, Nangang, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hand and Microsurgery Center, The Second Affiliated Hospital of Harbin Medical University, Nangang, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Miao","sequence":"additional","affiliation":[{"name":"Hand and Microsurgery Center, The Second Affiliated Hospital of Harbin Medical University, Nangang, Harbin 150081, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul 10100, 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