{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T09:10:39Z","timestamp":1763111439094,"version":"3.45.0"},"reference-count":7,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Primary spinal epidural lymphoma (PSEL) is rare, accounting for just 0.1\u20136.5% of all extranodal lymphomas and 9% of all primary spinal epidural tumors. They are mostly located in the thoracic spine, with only occasional cervical spine involvement. Here, a 74-year-old male presented with a cervical epidural diffuse large B-cell lymphoma (DLBCL) that was successfully managed with an emergent surgical decompression.<\/jats:p>\n <\/jats:sec>\n \n Case Description:<\/jats:title>\n A 74-year-old male presented with the acute onset of quadriparesis. The magnetic resonance imaging (MRI) revealed thickening of the posterior longitudinal ligament at C2\u20133, an epidural mass posterior to the spinal cord from C3\u20135, causing spinal cord compression, maximal at the C4\u20135 level. Six days after admission, the patient underwent a C2 partial and full C3\u20134 laminectomy; it resulted in improvement of quadriparesis. Pathology confirmed the diagnosis of CD20-positive DLBCL, and he subsequently received appropriate chemotherapy\/radiotherapy.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Spinal cord compression is the sole presenting symptom in <5% of malignant lymphoma cases. Here, a 74-year-old male developed an acute quadriparesis attributed to a C3-C5 DLBCL that was successfully managed with a C2-C4 laminectomy, followed by appropriate chemotherapy and radiation.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_1019_2025","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T09:06:48Z","timestamp":1763111208000},"page":"476","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A case of rapidly progressive cervical primary spinal epidural lymphoma"],"prefix":"10.25259","volume":"16","author":[{"given":"Shota","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Suzuka Kaisei Hospital, Suzuka City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Suzuka Kaisei Hospital, Suzuka City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mie University Graduate School of Medicine, Tsu City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akari","family":"Noro","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Suzuka Kaisei Hospital, Suzuka City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Shiba","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Suzuka Kaisei Hospital, Suzuka City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Araki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Suzuka Kaisei Hospital, Suzuka City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waka","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Hematology, Suzuka Kaisei Hospital, Suzuka City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Suzuka Kaisei Hospital, Suzuka City, Japan"},{"name":"Department of Minimum-Invasive Neurospinal Surgery, Mie University School of Medicine, Tsu City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"10.25259\/SNI_1019_2025\/ref-1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2176\/nmc.43.471","article-title":"Review of spinal epidural cavernous hemangioma","volume":"43","author":"Aoyagi","year":"2003","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"10.25259\/SNI_1019_2025\/ref-2","first-page":"e28934","article-title":"Primary spinal epidural diffuse large B-cell lymphoma: Case report and literature review","volume":"14","author":"Bhardwaj","year":"2022","journal-title":"Cureus"},{"key":"10.25259\/SNI_1019_2025\/ref-3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/1477-7819-11-90","article-title":"Surgical decompression improves recovery from neurological deficit and may provide a survival benefit in patients with diffuse large B-cell lymphoma-associated spinal cord compression: A case-series study","volume":"11","author":"Chang","year":"2013","journal-title":"World J Surg Oncol"},{"key":"10.25259\/SNI_1019_2025\/ref-4","doi-asserted-by":"crossref","first-page":"395","DOI":"10.5414\/NPP28395","article-title":"Diffuse follicle center lymphoma of the spine: A primary epidural lymphoma?","volume":"28","author":"Mesfin","year":"2009","journal-title":"Clin Neuropathol"},{"key":"10.25259\/SNI_1019_2025\/ref-5","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ijrobp.2006.01.002","article-title":"Primary spinal epidural lymphoma: Patients\u2019 profile, outcome, and prognostic factors: A multicenter rare cancer network study","volume":"65","author":"Monnard","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.25259\/SNI_1019_2025\/ref-6","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.3892\/or_00000350","article-title":"Primary non-Hodgkin\u2019s lymphoma of the spine with neurologic compression treated by radiotherapy and chemotherapy alone or combined with surgical decompression","volume":"21","author":"Peng","year":"2009","journal-title":"Oncol Rep"},{"key":"10.25259\/SNI_1019_2025\/ref-7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12885-017-3093-z","article-title":"Clinicopathologic characteristics and prognostic factors for primary spinal epidural lymphoma: Report 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