{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T15:12:22Z","timestamp":1771341142919,"version":"3.50.1"},"reference-count":28,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nPolymorphous low-grade neuroepithelial tumor of the young (PLNTY) is a newly recognized entity first described in 2017. This article reports the clinical, radiological, histological, and molecular characteristics of PLNTY diagnosed in a young female.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nA 20-year-old female, not known to have any medical illness, presented to the emergency department with speech arrest that progressed to generalized tonic-clonic seizures. Brain magnetic resonance imaging showed a T2 hyperintense nonenhancing cortical-based heterogeneous mass in the left medial temporal lobe and adjacent inferior temporal gyrus measuring 2.7 \u00d7 2 \u00d7 2.5 cm with no susceptibility signal or diffusion restriction. Electroencephalogram (EEG) showed left temporal epileptiform discharges. She underwent left frontotemporal craniotomy and tumor resection. The light microscopic examination of the tumor revealed a low-grade infiltrative neoplasm. There was a classical appearance of round cells with perinuclear halo, immunopositive for olig-2, glial fibrillary acidic protein (GFAP)<\/jats:italic>, and cluster of differentiation-34. There was B-Raf protooncogene, serine\/threonine kinase (BRA<\/jats:italic>F) c.1799T>A (p.V600E) point mutation and absence of isocitrate dehydrogenase (IDH)<\/jats:italic> 1 and 2 hotspot mutations. The overall findings were diagnostic of PLNTY.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nThis article reports an additional case of PLNTY, a newly defined central nervous system tumor entity, describing its clinical, radiological, histological, and molecular features.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_1061_2024","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:23:44Z","timestamp":1753439024000},"page":"300","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Polymorphous low-grade neuroepithelial tumor of the young"],"prefix":"10.25259","volume":"16","author":[{"given":"Ahoud","family":"Alharbi","sequence":"first","affiliation":[{"name":"College of Medicine, King Saud Bin Abdulaziz University for Health Sciences (KSAUHS), Riyadh, Saudi Arabia"},{"name":"King Abdullah International Research Center (KAIMRC), Riyadh, Saudi Arabia"},{"name":"Division of Neurosurgery, Department of Surgery, King Abdulaziz Medical City (KAMC), Ministry of National Guard Health Affairs (NGHA), Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Alassiri","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud Bin Abdulaziz University for Health Sciences (KSAUHS), Riyadh, Saudi Arabia"},{"name":"King Abdullah International Research Center (KAIMRC), Riyadh, Saudi Arabia"},{"name":"Division of Neuropathology, Department of Pathology, King Abdulaziz Medical City (KAMC), Ministry of National Guard Health Affairs (NGHA), Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Alkhaibary","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud Bin Abdulaziz University for Health Sciences (KSAUHS), Riyadh, Saudi Arabia"},{"name":"King Abdullah International Research Center (KAIMRC), Riyadh, Saudi Arabia"},{"name":"Division of Neurosurgery, Department of Surgery, King Abdulaziz Medical City (KAMC), Ministry of National Guard Health Affairs (NGHA), Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saad","family":"AlQahatani","sequence":"additional","affiliation":[{"name":"King Abdullah International Research Center (KAIMRC), Riyadh, Saudi Arabia"},{"name":"Division of Neurosurgery, Department of Surgery, King Abdulaziz Medical City (KAMC), Ministry of National Guard Health Affairs (NGHA), Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"10.25259\/SNI_1061_2024\/ref-1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s13760-023-02231-z","article-title":"Radiological and surgical aspects of polymorphous low-grade neuroepithelial tumor of the young (PLNTY)","volume":"123","author":"Armocida","year":"2023","journal-title":"Acta Neurol Belg"},{"key":"10.25259\/SNI_1061_2024\/ref-2","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40478-020-00898-6","article-title":"FGFRgene family alterations in low-grade neuroepithelial tumors","volume":"8","author":"Bale","year":"2020","journal-title":"Acta Neuropathol Commun"},{"key":"10.25259\/SNI_1061_2024\/ref-3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00401-020-02245-4","article-title":"Malignant transformation of a polymorphous low grade neuroepithelial tumor of the young (PLNTY)","volume":"141","author":"Bale","year":"2021","journal-title":"Acta Neuropathol"},{"key":"10.25259\/SNI_1061_2024\/ref-4","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3174\/ajnr.A6500","article-title":"Polymorphous low-grade neuroepithelial tumor of the young as a partially calcified intra-axial mass in an adult","volume":"41","author":"Benson","year":"2020","journal-title":"Am J Neuroradiol"},{"key":"10.25259\/SNI_1061_2024\/ref-5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.5414\/NP301081","article-title":"A newly diagnosed case of polymorphous low-grade neuroepithelial tumor of the young","volume":"37","author":"Bitar","year":"2018","journal-title":"Clin Neuropathol"},{"key":"10.25259\/SNI_1061_2024\/ref-6","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00401-014-1288-9","article-title":"A neuropathology-based approach to epilepsy surgery in brain tumors and proposal for a new terminology use for long-term epilepsy-associated brain tumors","volume":"128","author":"Blumcke","year":"2014","journal-title":"Acta Neuropathol"},{"key":"10.25259\/SNI_1061_2024\/ref-7","doi-asserted-by":"crossref","first-page":"470","DOI":"10.25259\/SNI_500_2021","article-title":"A \u201cpolymorphous low-grade neuroepithelial tumor of the young (PLNTY)\u201d diagnosed in an adult. 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