{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:37:02Z","timestamp":1776209822609,"version":"3.50.1"},"reference-count":9,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Intracranial epidermoid cysts are infrequent, benign, and slow-growing lesions derived from ectodermal vestiges. Although extremely uncommon, these lesions represent a great challenge from a diagnostic and surgical point of view because they are located close to major neurovascular structures with great potential for complications. Our work aims to analyze demographic, clinical, radiological, and surgical features in patients with intracranial epidermoid cysts and to assess post-surgical outcomes to define better management strategies.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Methods: <\/jats:title>\n<jats:p>We conducted a retrospective cohort study of patients diagnosed with histologically confirmed intracranial epidermoid cysts and treated surgically at Dr. Said Al-Witry\u2019s Neuroscience Hospital from January 2020 to September 2024. Demographic data, clinical presentations, imaging findings, surgical approaches, and postoperative complications were analyzed using descriptive statistics and Chi-square tests. Statistical significance was set at <jats:italic>P<\/jats:italic> &lt; 0.05.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Results: <\/jats:title>\n<jats:p>Out of 40 patients, 75% were male, with headaches being the most common symptom (50%). Magnetic resonance imaging (MRI) findings demonstrated T1 hypo-intensity in 95% and T2 hyper-intensity in all cases. The retrosigmoid approach was the most frequently employed surgical method (60%), followed by frontotemporal (30%) and midline suboccipital (10%) approaches. Postoperative complications occurred in 35% of cases, including facial nerve palsy (15%), aseptic meningitis (10%), cerebrospinal fluid leaks (5%), and hydrocephalus (5%). Chi-square analysis showed significant associations between surgical approaches and postoperative complications (<jats:italic>P<\/jats:italic> = 0.048).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st4\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>Intracranial epidermoid cysts show a high incidence in males and present mostly with nonspecific symptoms such as headaches and seizures. MRI remains the key investigation modality. The retrosigmoid approach shows less complication rate when compared to other techniques. Even though surgery has evolved, complications such as meningitis and nerve palsy persist, so much attention to detail is required in preoperative planning and follow-up in the long run for optimum outcomes for the patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_1085_2024","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T06:35:15Z","timestamp":1738305315000},"page":"30","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intracranial epidermoid cysts: Demographics, surgical strategies, and postoperative outcomes in a retrospective cohort study"],"prefix":"10.25259","volume":"16","author":[{"given":"Moneer K.","family":"Faraj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"10.25259\/SNI_1085_2024\/ref-1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.3171\/2014.11.JNS1481","article-title":"Giant intracranial epidermoids: Is total removal feasible?","volume":"122","author":"Aboud","year":"2015","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_1085_2024\/ref-2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1055\/s-0037-1606220","article-title":"Surgical resection of cerebellopontine epidermoid cysts: limitations and outcome","volume":"79","author":"Farhoud","year":"2018","journal-title":"J Neurol Surg Part B Skull Base"},{"key":"10.25259\/SNI_1085_2024\/ref-3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s10143-015-0684-5","article-title":"Cerebellopontine angle epidermoid cysts: clinical presentations and surgical outcome","volume":"39","author":"Hasegawa","year":"2016","journal-title":"Neurosurg Rev"},{"key":"10.25259\/SNI_1085_2024\/ref-4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00401-007-0243-4","article-title":"The 2007 WHO classification of tumours of the central nervous system","volume":"114","author":"Louis","year":"2007","journal-title":"Acta Neuropathol"},{"key":"10.25259\/SNI_1085_2024\/ref-5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3171\/2016.11.JNS161605","article-title":"Complete endoscopic resection of a pituitary stalk epidermoid cyst using a combined infrasellar interpituitary and suprasellar endonasal approach: Case report","volume":"128","author":"Nakassa","year":"2017","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_1085_2024\/ref-6","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1097\/SCS.0000000000006834","article-title":"Epidermoid and dermoid cysts of the head and neck","volume":"32","author":"Pupi\u0107-Bakra\u010d","year":"2021","journal-title":"J Craniofac Surg"},{"key":"10.25259\/SNI_1085_2024\/ref-7","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.3171\/2010.12.JNS10325","article-title":"Delayed postoperative hemorrhage in 21 patients with intracranial epidermoid cysts","volume":"114","author":"Ren","year":"2011","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_1085_2024\/ref-8","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3171\/2017.7.JNS162783","article-title":"Endoscopic endonasal surgery for epidermoid and dermoid cysts: A 10-year experience","volume":"130","author":"Vaz-Guimaraes","year":"2018","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_1085_2024\/ref-9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1227\/00006123-199501000-00006","article-title":"Intradural epidermoid cysts of the cerebellopontine angle: Diagnosis and surgery","volume":"36","author":"Vinchon","year":"1995","journal-title":"Neurosurgery"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/intracranial-epidermoid-cysts-demographics-surgical-strategies-and-postoperative-outcomes-in-a-retrospective-cohort-study\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/intracranial-epidermoid-cysts-demographics-surgical-strategies-and-postoperative-outcomes-in-a-retrospective-cohort-study\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T06:35:24Z","timestamp":1738305324000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/intracranial-epidermoid-cysts-demographics-surgical-strategies-and-postoperative-outcomes-in-a-retrospective-cohort-study\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":9,"alternative-id":["10.25259\/SNI_1085_2024"],"URL":"https:\/\/doi.org\/10.25259\/sni_1085_2024","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1,31]]},"article-number":"30"}}