{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T10:07:09Z","timestamp":1784887629620,"version":"3.55.0"},"reference-count":32,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Malignant peripheral nerve sheath tumors (MPNSTs) constitute a group of malignant neoplasms with neuroectodermal origin. MPNSTs are rare, with an expected incidence of 0.1\/100,000 per year. Occurrences of MPNSTs on the scalp are exceptionally rare, with only 26 cases involving the scalp reported in the published literature. We wish to report a rare case of giant scalp MPNST and discuss the management options of this rare entity, along with the literature review pertaining to the same.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>Case Description:<\/jats:title>\n                    <jats:p>\n                      A 50-year-old male presented with a firm to hard swelling on the top of his head for the past 8 months. Magnetic resonance imaging showed an extra-axial, transcalvarial heterogeneously enhancing lesion of size 10 cm \u00d7 9 cm \u00d7 7 cm in the midline in the frontoparietal convexity. The patient underwent bi-frontal craniectomy with gross total resection of the tumor mass with titanium mesh cranioplasty. His postoperative period was uneventful, and he was discharged on the 7\n                      <jats:sup>th<\/jats:sup>\n                      postoperative day.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The cases of MPNST should be treated by resection of the affected bone and cranioplasty followed by radiation therapy. Chemotherapy is reserved for high-grade lesions with distant metastasis. The overall survival rate for these highly aggressive tumors is frequently restricted, with a reported figure of approximately 30% over 5 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.25259\/sni_108_2025","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T09:42:19Z","timestamp":1784886139000},"page":"422","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Giant scalp malignant peripheral nerve sheath tumor with bone involvement: Case report and review of the literature"],"prefix":"10.25259","volume":"17","author":[{"given":"Kunal","family":"Singla","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puspendu","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrutika","family":"Chopra","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi Hari","family":"Phulware","sequence":"additional","affiliation":[{"name":"Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"10.25259\/SNI_108_2025\/ref-1","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/cncr.22098","article-title":"Malignant peripheral nerve sheath tumors: Prognostic factors and survival in a series of patients treated at a single institution","volume":"107","author":"Anghileri","year":"2006","journal-title":"Cancer"},{"key":"10.25259\/SNI_108_2025\/ref-2","doi-asserted-by":"crossref","first-page":"916","DOI":"10.4236\/ijcm.2014.515123","article-title":"Malignant peripheral nerve sheath tumors of the scalp: Case report and review of Literature","volume":"5","author":"Bouhafa","year":"2014","journal-title":"Int J Clin Med"},{"key":"10.25259\/SNI_108_2025\/ref-3","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.wneu.2020.03.039","article-title":"Giant malignant peripheral nerve sheath tumor of the scalp: Case 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