{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:41:08Z","timestamp":1789026068826,"version":"build-2803163510"},"reference-count":10,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nCerebral amyloid angiopathy (CAA) is a neurological condition characterized by the deposition of amyloid beta particles within the cerebral vasculature over time. A rare complication of CAA is an autoimmune inflammatory syndrome to cerebrovascular amyloid deposits. In this report, we present a case of CAA-related inflammation (CAA-RI) and discuss the diagnostic and management considerations when encountering this pathology.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nA 69-year-old man with a history of hypertension, hyperlipidemia, obstructive sleep apnea, benign prostatic hyperplasia, and major depressive disorder presented to the clinic with rapidly progressive cognitive impairment over the preceding 2 months. Magnetic resonance imaging (MRI) of the brain demonstrated white matter hyperintense lesions associated with innumerable microbleeds asymmetrically concentrated in the right parietal lobe, with subtle hyperattenuation of the sulci. These findings suggested a diagnosis of probable CAA-RI. The patient was started on intravenous methylprednisolone, one gram daily for 5 days, followed by a prolonged prednisone taper over the next 6 weeks.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nPatients with CAA-RI typically present with cognitive decline, followed by focal neurologic deficits, seizures, and headaches. On MRI of the brain, T2\/fluid-attenuated inversion recovery asymmetric hyperintense white matter lesions local to cerebral microbleeds are characteristic. Management of CAA-RI involves high-dose corticosteroids with emerging investigation of immunosuppressive therapies.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_1097_2024","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T09:32:45Z","timestamp":1738920765000},"page":"37","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Diagnosis and management of a mild case of cerebral amyloid angiopathy-related inflammation: A case report"],"prefix":"10.25259","volume":"16","author":[{"given":"Archit Bharathwaj","family":"Baskaran","sequence":"first","affiliation":[{"name":"Department of Neurology, The University of Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia A","family":"Kozel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Warren Alpert Medical School of Brown University, Providence, RI, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Jhaveri","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The University of Chicago, Pritzker School of Medicine, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranay","family":"Vadapally","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Neurosurgery, Midwestern University, Chicago College of Osteopathic Medicine, Downers Grove, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chibueze","family":"Agwu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The University of Chicago, Pritzker School of Medicine, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin A","family":"Kothari","sequence":"additional","affiliation":[{"name":"Department of Neurology, The University of Chicago, Chicago, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary B","family":"Bulwa","sequence":"additional","affiliation":[{"name":"Department of Vascular Neurology, Endeavor Health Medical Group, Evanston, Illinois, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"10.25259\/SNI_1097_2024\/ref-1","doi-asserted-by":"crossref","first-page":"e1809","DOI":"10.1212\/WNL.0000000000012778","article-title":"Spontaneous ARIA-like events in cerebral amyloid angiopathy-related inflammation: A multicenter prospective longitudinal cohort study","volume":"97","author":"Antolini","year":"2021","journal-title":"Neurology"},{"key":"10.25259\/SNI_1097_2024\/ref-2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1001\/jamaneurol.2015.4078","article-title":"Validation of clinicoradiological criteria for the diagnosis of cerebral amyloid angiopathy-related inflammation","volume":"73","author":"Auriel","year":"2016","journal-title":"JAMA Neurol"},{"key":"10.25259\/SNI_1097_2024\/ref-3","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/brain\/awx047","article-title":"Emerging concepts in sporadic cerebral amyloid angiopathy","volume":"140","author":"Charidimou","year":"2017","journal-title":"Brain"},{"key":"10.25259\/SNI_1097_2024\/ref-4","doi-asserted-by":"crossref","first-page":"120866","DOI":"10.1016\/j.jns.2023.120866","article-title":"Exploring cerebral amyloid angiopathy: Insights into pathogenesis, diagnosis, and treatment","volume":"454","author":"Cozza","year":"2023","journal-title":"J Neurol Sci"},{"key":"10.25259\/SNI_1097_2024\/ref-5","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1177\/1747493020974464","article-title":"A practical approach to the management of cerebral amyloid angiopathy","volume":"16","author":"Kozberg","year":"2021","journal-title":"Int J Stroke"},{"key":"10.25259\/SNI_1097_2024\/ref-6","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1001\/jamaneurol.2020.1782","article-title":"Association between immunosuppressive treatment and outcomes of cerebral amyloid angiopathy-related inflammation","volume":"77","author":"Regenhardt","year":"2020","journal-title":"JAMA Neurol"},{"key":"10.25259\/SNI_1097_2024\/ref-7","doi-asserted-by":"crossref","first-page":"e3613","DOI":"10.1097\/MD.0000000000003613","article-title":"Imaging findings of cerebral amyloid angiopathy, A\u03b2-related angiitis (ABRA), and cerebral amyloid angiopathy-related inflammation: A single-institution 25-year experience","volume":"95","author":"Salvarani","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"10.25259\/SNI_1097_2024\/ref-8","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1161\/STROKEAHA.122.040671","article-title":"Clinical, neuroimaging, and genetic markers in cerebral amyloid angiopathy-related inflammation: A systematic review and Meta-analysis","volume":"54","author":"Theodorou","year":"2023","journal-title":"Stroke"},{"key":"10.25259\/SNI_1097_2024\/ref-9","doi-asserted-by":"crossref","first-page":"6731","DOI":"10.3390\/jcm11226731","article-title":"Cerebral amyloid angiopathy-related inflammation: A single-center experience and a literature review","volume":"11","author":"Theodorou","year":"2022","journal-title":"J Clin Med"},{"key":"10.25259\/SNI_1097_2024\/ref-10","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1080\/14737175.2018.1480938","article-title":"Cerebral amyloid angiopathy: Diagnosis and potential therapies","volume":"18","author":"Weber","year":"2018","journal-title":"Expert Rev Neurother"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/diagnosis-and-management-of-a-mild-case-of-cerebral-amyloid-angiopathy-related-inflammation-a-case-report\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/diagnosis-and-management-of-a-mild-case-of-cerebral-amyloid-angiopathy-related-inflammation-a-case-report\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T09:32:49Z","timestamp":1738920769000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/diagnosis-and-management-of-a-mild-case-of-cerebral-amyloid-angiopathy-related-inflammation-a-case-report\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,7]]},"references-count":10,"alternative-id":["10.25259\/SNI_1097_2024"],"URL":"https:\/\/doi.org\/10.25259\/sni_1097_2024","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2,7]]},"article-number":"37"}}