{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:48:30Z","timestamp":1790642910952,"version":"4.1.0"},"reference-count":21,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n \n Sparganosis is a rare parasitic infection caused by the plerocercoid larvae (spargana) of\n Spirometra<\/jats:italic>\n species. Central nervous system (CNS) involvement is uncommon; cerebral sparganosis can be particularly challenging to diagnose because its clinical presentation and imaging features often mimic those of more common parasitic infections (e.g., neurocysticercosis) or neoplastic lesions.\n <\/jats:p>\n <\/jats:sec>\n \n Case Description:<\/jats:title>\n \n A 74-year-old woman with slowly progressive Alzheimer\u2019s disease, who had undergone regular brain magnetic resonance imaging (MRI) examinations over the past three years, was incidentally found to have a slowly enlarging lesion with surrounding edema in the left frontal lobe on MRI of the brain. The lesion demonstrated calcification and radiological features atypical for a neoplastic process, thus prompting a left frontal craniotomy for diagnostic purposes. Intraoperatively, a whitish, linear structure was removed. Frozen section revealed granulomatous inflammation with parasitic structures. Molecular biological analysis identified the specimen as a\n Spirometra<\/jats:italic>\n larva (Type I), confirming the diagnosis of cerebral sparganosis. Postoperatively, her baseline cognitive impairment persisted; however, follow-up MRI at 1 month demonstrated resolution of the enhancing lesion, and no new neurological deficits occurred.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Cerebral sparganosis should be considered in the differential diagnosis of intracranial mass lesions with a tumor-like appearance. Although the diagnosis remains challenging, molecular techniques permit definitive confirmation. Surgical resection serves a dual role, facilitating both accurate diagnosis and treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_1111_2025","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T08:29:05Z","timestamp":1764923345000},"page":"512","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of cerebral sparganosis diagnosed by surgical resection and molecular analysis"],"prefix":"10.25259","volume":"16","author":[{"given":"Ryo","family":"Miyahara","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Juntendo University Faculty of Medicine, Bunkyo, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Juntendo University Faculty of Medicine, Bunkyo, Tokyo, 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