{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T09:26:06Z","timestamp":1787304366562,"version":"build-2736575974"},"reference-count":31,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The possible causal relationship between traumatic brain injury and subsequent meningioma development remains controversial. Although historical and anecdotal reports have suggested a post-traumatic origin of meningiomas, robust epidemiological evidence is lacking, and the distinction between causality and coincidence remains challenging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>Case Description:<\/jats:title>\n                    <jats:p>We report the case of a 78-year-old man who sustained a severe frontal cranial trauma with a comminuted fracture and retained foreign body 40 years earlier, treated surgically by craniectomy. Decades later, the patient presented with a headache and cognitive disturbance. Neuroimaging revealed a frontal meningioma arising beneath and within the previous craniectomy site. The tumor was successfully removed en bloc through navigated craniectomy, followed by dural reconstruction and cranioplasty. Histopathological examination confirmed a benign meningioma. The postoperative course was uneventful, and follow-up imaging showed no recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Rather than supporting a traumatic origin of meningioma, this case underscores the limitations in attributing causality between head trauma and tumor development. It emphasizes the need for cautious interpretation of post-traumatic tumor cases and provides clinically relevant insights into the evaluation of meningioma etiology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.25259\/sni_1127_2025","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:48:07Z","timestamp":1787302087000},"page":"470","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Post-traumatic meningioma or coincidental occurrence? A case report and critical review of the literature"],"prefix":"10.25259","volume":"17","author":[{"given":"Antonello","family":"Curcio","sequence":"first","affiliation":[{"name":"UOC di Neurochirurgia, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shervin","family":"Espahbodinea","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Science and Morphofunctional Imaging, Unit of Neurosurgery, University of Messina, Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Raffa","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Science and Morphofunctional Imaging, Unit of Neurosurgery, University of Messina, Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino Francesco","family":"German\u00f2","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Science and Morphofunctional Imaging, Unit of Neurosurgery, University of Messina, Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"10.25259\/SNI_1127_2025\/ref-1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1093\/neuonc\/noy162","article-title":"Nonmalignant and malignant meningioma incidence and survival in the elderly, 2005-2015, using the Central Brain Tumor Registry of the United States","volume":"21","author":"Achey","year":"2019","journal-title":"Neuro Oncol"},{"key":"10.25259\/SNI_1127_2025\/ref-2","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/BF01246883","article-title":"Traumatic origin of a meningioma?","volume":"107","author":"Betz","year":"1995","journal-title":"Int J Legal Med"},{"key":"10.25259\/SNI_1127_2025\/ref-3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1258\/002221504322928035","article-title":"Post-traumatic cutaneous meningioma","volume":"118","author":"Borggreven","year":"2004","journal-title":"J Laryngol Otol"},{"key":"10.25259\/SNI_1127_2025\/ref-4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1177\/030089160308900102","article-title":"Post-traumatic intracranial meningiomas","volume":"89","author":"Caroli","year":"2003","journal-title":"Tumori"},{"key":"10.25259\/SNI_1127_2025\/ref-5","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1089\/neu.2011.2235","article-title":"Association between traumatic brain injury and the subsequent risk of brain cancer","volume":"29","author":"Chen","year":"2012","journal-title":"J Neurotrauma"},{"key":"10.25259\/SNI_1127_2025\/ref-6","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"key":"10.25259\/SNI_1127_2025\/ref-7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1742-2094-9-11","article-title":"Eosinophils in glioblastoma biology","volume":"9","author":"Curran","year":"2012","journal-title":"J Neuroinflammation"},{"key":"10.25259\/SNI_1127_2025\/ref-8","first-page":"281","article-title":"The modern attitude toward traumatic cancer","volume":"11","author":"Ewing","year":"1935","journal-title":"Bull N Y Acad Med"},{"key":"10.25259\/SNI_1127_2025\/ref-9","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S1470-2045(07)70107-9","article-title":"Genetic predisposition for the development of radiation-associated meningioma: An epidemiological study","volume":"8","author":"Flint-Richter","year":"2007","journal-title":"Lancet Oncol"},{"key":"10.25259\/SNI_1127_2025\/ref-10","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1007\/s00701-010-0730-6","article-title":"Post-traumatic meningioma: Three case reports of this rare condition and a review of the literature","volume":"152","author":"Fran\u00e7ois","year":"2010","journal-title":"Acta Neurochir (Wien)"},{"key":"10.25259\/SNI_1127_2025\/ref-11","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/bjc.2011.61","article-title":"Search for inherited susceptibility to radiation-associated meningioma by genomewide SNP linkage disequilibrium mapping","volume":"104","author":"Hosking","year":"2011","journal-title":"Br J Cancer"},{"key":"10.25259\/SNI_1127_2025\/ref-12","first-page":"109","article-title":"Incidence of intracranial tumors following hospitalization for head injuries (Denmark)","volume":"9","author":"Inskip","year":"1998","journal-title":"Cancer Causes Control"},{"key":"10.25259\/SNI_1127_2025\/ref-13","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1038\/sj.onc.1210031","article-title":"A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo","volume":"26","author":"Iwamaru","year":"2007","journal-title":"Oncogene"},{"key":"10.25259\/SNI_1127_2025\/ref-14","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1007\/s00701-010-0733-3","article-title":"Post-traumatic meningioma: Three case reports of this rare condition and a review of the literature","volume":"152","author":"J\u00e4\u00e4skel\u00e4inen","year":"2010","journal-title":"Acta Neurochir (Wien)"},{"key":"10.25259\/SNI_1127_2025\/ref-15","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1136\/jnnp.66.6.796","article-title":"Post-traumatic meningioma: Case report and historical perspective","volume":"66","author":"Kotzen","year":"1999","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.25259\/SNI_1127_2025\/ref-16","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.2147\/JIR.S325678","article-title":"The promoting effect of traumatic brain injury on the incidence and progression of glioma: A review of clinical and experimental research","volume":"14","author":"Lan","year":"2021","journal-title":"J Inflamm Res"},{"key":"10.25259\/SNI_1127_2025\/ref-17","doi-asserted-by":"crossref","first-page":"e68963","DOI":"10.1371\/journal.pone.0068963","article-title":"Oxidative burst of circulating neutrophils following traumatic brain injury in humans","volume":"8","author":"Liao","year":"2013","journal-title":"PLoS One"},{"key":"10.25259\/SNI_1127_2025\/ref-18","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3171\/jns.1982.56.4.0471","article-title":"The case of general wood","volume":"56","author":"Ljunggren","year":"1982","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_1127_2025\/ref-19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.5999\/aps.2016.43.4.381","article-title":"Post-traumatic cutaneous meningioma","volume":"43","author":"Pacheco Compa\u00f1a","year":"2016","journal-title":"Arch Plast Surg"},{"key":"10.25259\/SNI_1127_2025\/ref-20","first-page":"863","article-title":"Risk factors for meningiomas in men in Los Angeles County","volume":"70","author":"Preston-Martin","year":"1983","journal-title":"J Natl Cancer Inst"},{"key":"10.25259\/SNI_1127_2025\/ref-21","first-page":"6137","article-title":"Risk factors for gliomas and meningiomas in males in Los Angeles County","volume":"49","author":"Preston-Martin","year":"1989","journal-title":"Cancer Res"},{"key":"10.25259\/SNI_1127_2025\/ref-22","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/ije\/27.4.579","article-title":"An international case-control study of adult glioma and meningioma: The role of head trauma","volume":"27","author":"Preston-Martin","year":"1998","journal-title":"Int J Epidemiol"},{"key":"10.25259\/SNI_1127_2025\/ref-23","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.3171\/FOC-07\/10\/E7","article-title":"Inflammatory response and meningioma tumorigenesis and the effect of cyclooxygenase-2 inhibitors","volume":"23","author":"Ragel","year":"2007","journal-title":"Neurosurg Focus"},{"key":"10.25259\/SNI_1127_2025\/ref-24","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1007\/s10143-022-01819-y","article-title":"Traumatic brain injury and subsequent brain tumor development: A systematic review of the literature","volume":"45","author":"Shah","year":"2022","journal-title":"Neurosurg Rev"},{"key":"10.25259\/SNI_1127_2025\/ref-25","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.3390\/ijms19082445","article-title":"The pathophysiology of post-traumatic glioma","volume":"19","author":"Simi\u0144ska","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.25259\/SNI_1127_2025\/ref-26","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3171\/jns.1966.24.1.0096","article-title":"Meningioma with traumatic etiology. Report of a case","volume":"24","author":"Turner","year":"1966","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_1127_2025\/ref-27","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4103\/2152-7806.189296","article-title":"Traumatic brain injury and subsequent glioblastoma development: Review of the literature and case reports","volume":"7","author":"Tyagi","year":"2016","journal-title":"Surg Neurol Int"},{"key":"10.25259\/SNI_1127_2025\/ref-28","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0140-6736(61)90960-6","article-title":"Head injuries as a factor in the aetiology of intracranial meningioma","volume":"278","author":"Walshe","year":"1961","journal-title":"Lancet"},{"key":"10.25259\/SNI_1127_2025\/ref-29","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/bjs.1800600622","article-title":"Meningioma following trauma","volume":"60","author":"Whatmore","year":"1973","journal-title":"Br J Surg"},{"key":"10.25259\/SNI_1127_2025\/ref-30","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1002\/glia.23523","article-title":"Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation","volume":"66","author":"Witcher","year":"2018","journal-title":"Glia"},{"key":"10.25259\/SNI_1127_2025\/ref-31","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.3892\/mmr.2014.2462","article-title":"Effect of siRNA-induced inhibition of IL-6 expression in rat cerebral gliocytes on cerebral edema following traumatic brain injury","volume":"10","author":"Xu","year":"2014","journal-title":"Mol Med Rep"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/post-traumatic-meningioma-or-coincidental-occurrence-a-case-report-and-critical-review-of-the-literature\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/post-traumatic-meningioma-or-coincidental-occurrence-a-case-report-and-critical-review-of-the-literature\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:48:11Z","timestamp":1787302091000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/post-traumatic-meningioma-or-coincidental-occurrence-a-case-report-and-critical-review-of-the-literature\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,21]]},"references-count":31,"alternative-id":["10.25259\/SNI_1127_2025"],"URL":"https:\/\/doi.org\/10.25259\/sni_1127_2025","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,21]]},"article-number":"470"}}