{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T10:30:48Z","timestamp":1767349848445,"version":"3.48.0"},"reference-count":12,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Elderly osteoporotic patients with kyphosis secondary to spinal tuberculosis (TB) are at high risk for implant failure. For these patients, polymethylmethacrylate (PMMA)-augmented pedicle screw fixation provides immediate stability but increases the risk of infection. Here, we evaluated the outcome for a 78-year-old osteoporotic female with TB-related kyphosis successfully managed with PMMA-augmented pedicle screw fusion.<\/jats:p>\n <\/jats:sec>\n \n Case Description:<\/jats:title>\n A 78-year-old female presented with mid-back pain, progressive kyphotic deformity, and increasing paraparesis. The magnetic resonance imaging revealed infectious T12-L1 spondylitis with accompanying vertebral body destruction\/kyphosis. She underwent a single-stage posterior PMMA-augmented screw fixation from T9-L4 supplemented with anterior reconstruction and cage\/bone grafting. The histology\/cultures were consistent with spinal TB for which she received anti-tuberculosis therapy, followed by once weekly teriparatide (60 \u00b5g for 6 weeks). Neurological recovery was complete within 3 months, and by 2 years, the imaging confirmed a stable fusion.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n A 78-year-old osteoporotic female with T12\/L1 TB-related spondylitis successfully underwent selective PMMA-augmented pedicle screw fixation from T9-L4 supplemented with anti-tubercular therapy.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_1140_2025","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T09:56:04Z","timestamp":1766742964000},"page":"552","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Senile thoracolumbar tuberculosis with kyphosis and severe osteoporosis treated with polymethylmethacrylate-augmented screw fixation"],"prefix":"10.25259","volume":"16","author":[{"given":"B. Yogesh","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, SRM Global Hospitals, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharath","family":"Loganathan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Soundarapandian Bone and Joint Hospital and Research Institute, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Vijayakumar","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, MIOT International Hospital, Chennai, Tamil Nadu, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"10.25259\/SNI_1140_2025\/ref-1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10195-011-0164-9","article-title":"Fenestrated pedicle screws for cement-augmented purchase in patients with bone softening: A review of 21 cases","volume":"12","author":"Amendola","year":"2011","journal-title":"J Orthop Traumatol"},{"key":"10.25259\/SNI_1140_2025\/ref-2","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1007\/s00198-017-3939-x","article-title":"Increased risk of incident osteoporosis and osteoporotic fracture in tuberculosis patients: A population-based study in a tuberculosis-endemic area","volume":"28","author":"Chen","year":"2017","journal-title":"Osteoporos Int"},{"key":"10.25259\/SNI_1140_2025\/ref-3","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1097\/BRS.0b013e3181d449ec","article-title":"Biomechanical analysis of pedicle screws in osteoporotic bone with bioactive cement augmentation using simulated in vivo multicomponent loading","volume":"36","author":"Choma","year":"2011","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.25259\/SNI_1140_2025\/ref-4","first-page":"1526","article-title":"[Polymethylmethacrylate-augmented screw fixation in treatment of senile thoracolumbar tuberculosis combined with severe osteoporosis]","volume":"34","author":"Li","year":"2020","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"key":"10.25259\/SNI_1140_2025\/ref-5","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.spinee.2016.04.015","article-title":"Biomechanical comparison of pedicle screw augmented with different volumes of polymethylmethacrylate in osteoporotic and severely osteoporotic cadaveric lumbar vertebrae: An experimental study","volume":"16","author":"Liu","year":"2016","journal-title":"Spine J"},{"key":"10.25259\/SNI_1140_2025\/ref-6","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1210\/jc.2011-3479","article-title":"Randomized teriparatide [human parathyroid hormone (PTH) 1-34] once-weekly efficacy research (TOWER) trial for examining the reduction in new vertebral fractures in subjects with primary osteoporosis and high fracture risk","volume":"97","author":"Nakamura","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"10.25259\/SNI_1140_2025\/ref-7","doi-asserted-by":"crossref","first-page":"E1210","DOI":"10.1097\/BRS.0b013e318205e3af","article-title":"Biomechanical evaluation of a novel fenestrated pedicle screw augmented with bone cement in osteoporotic spines","volume":"36","author":"Par\u00e9","year":"2011","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.25259\/SNI_1140_2025\/ref-8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.4184\/asj.2014.8.4.498","article-title":"Weekly teriparatide therapy rapidly accelerates bone healing in pyogenic spondylitis with severe osteoporosis","volume":"8","author":"Shinohara","year":"2014","journal-title":"Asian Spine J"},{"key":"10.25259\/SNI_1140_2025\/ref-9","first-page":"55","article-title":"Clinical features and management of spinal tuberculosis in the elderly: A retrospective study","volume":"11","author":"Wang","year":"2016","journal-title":"J Orthop Surg Res"},{"key":"10.25259\/SNI_1140_2025\/ref-10","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1007\/s00586-018-5660-7","article-title":"Time to augment?! Impact of cement augmentation on pedicle screw fixation strength depending on bone mineral density","volume":"27","author":"Weiser","year":"2018","journal-title":"Eur Spine J"},{"key":"10.25259\/SNI_1140_2025\/ref-11","first-page":"661","article-title":"The challenges of osteoporosis in spinal tuberculosis surgery in the elderly","volume":"31","author":"Zhang","year":"2019","journal-title":"Aging Clin Exp Res"},{"key":"10.25259\/SNI_1140_2025\/ref-12","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.spinee.2015.02.032","article-title":"Spinal tuberculosis of the lumbar spine after percutaneous vertebral augmentation (vertebroplasty or kyphoplasty)","volume":"15","author":"Zou","year":"2015","journal-title":"Spine J"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/senile-thoracolumbar-tuberculosis-with-kyphosis-and-severe-osteoporosis-treated-with-polymethylmethacrylate-augmented-screw-fixation\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/senile-thoracolumbar-tuberculosis-with-kyphosis-and-severe-osteoporosis-treated-with-polymethylmethacrylate-augmented-screw-fixation\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T10:28:03Z","timestamp":1767349683000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/senile-thoracolumbar-tuberculosis-with-kyphosis-and-severe-osteoporosis-treated-with-polymethylmethacrylate-augmented-screw-fixation\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":12,"alternative-id":["10.25259\/SNI_1140_2025"],"URL":"https:\/\/doi.org\/10.25259\/sni_1140_2025","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"type":"electronic","value":"2152-7806"},{"type":"print","value":"2229-5097"}],"subject":[],"published":{"date-parts":[[2025,12,26]]},"article-number":"552"}}