{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T23:42:42Z","timestamp":1776469362599,"version":"3.51.2"},"reference-count":19,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nFibromuscular dysplasia (FMD) can cause cerebral aneurysms and dissection, which can lead to stroke. Angiographic findings are important in the diagnosis. We report a case of FMD in which the cause of hemorrhage could not be determined by angiography.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nA 73-year-old woman suffered from intracerebral hemorrhage (ICH) associated with FMD without abnormal angiography cerebral vessels. She presented with headache and nausea. Subsequent head-computed tomography-revealed ICH in the left frontal lobe, and contrast-enhanced magnetic resonance imaging revealed a gadolinium-enhancing lesion in the perihematoma area and in the genu of the corpus callosum. Although cerebral angiography revealed a string of beads appearance in the bilateral extracranial internal carotid arteries, no abnormality explaining the hemorrhage was identified. The hematoma was removed and the pathological diagnosis was FMD. In the pathological specimen, various patterns of vulnerable vessels, such as aneurysmal dilatation and obstruction, were observed, which could easily collapse and result in hemorrhage. In the case of ICH of unknown origin, microscopic vessel disruption due to FMD should also be considered.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nFMD can cause ICH in microscopic vascular lesions that are undetectable on angiography.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_1193_2021","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T11:00:49Z","timestamp":1642676449000},"page":"26","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A case of fibromuscular dysplasia related intracerebral hemorrhage without angiographically cerebral abnormal vessels"],"prefix":"10.25259","volume":"13","author":[{"given":"Gaku","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Kyoto Prefectural University of Medicine, Japanese Red Cross Society, Kyoto Daini Hospital, Kyoto, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kyoto Prefectural University of Medicine, Japanese Red Cross Society, Kyoto Daini Hospital, Kyoto, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetosho","family":"Okabe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Nishinotoin Bukkoji Clinic, Japanese Red Cross Society, Kyoto Daini Hospital, Kyoto, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiro","family":"Komaru","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Japanese Red Cross Society, Kyoto Daini Hospital, Kyoto, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Japanese Red Cross Society, Kyoto Daini Hospital, Kyoto, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanade","family":"Katsura","sequence":"additional","affiliation":[{"name":"Department of Pathology, Japanese Red Cross Society, Kyoto Daini Hospital, Kyoto, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobukuni","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Japanese Red Cross Society, Kyoto Daini Hospital, Kyoto, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kyoto Prefectural University of Medicine, Japanese Red Cross Society, Kyoto Daini Hospital, Kyoto, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2022,1,20]]},"reference":[{"key":"10.25259\/SNI_1193_2021\/ref-1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1161\/01.STR.16.2.255","article-title":"Fibromuscular dysplasia of cervico-cephalic arteries with multiple dissections and a carotid-cavernous fistula. A pathological study","volume":"16","author":"Bellot","year":"1985","journal-title":"Stroke"},{"key":"10.25259\/SNI_1193_2021\/ref-2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1177\/1358863X18821816","article-title":"First international consensus on the diagnosis and management of fibromuscular dysplasia","volume":"24","author":"Gornik","year":"2019","journal-title":"Vasc Med (United Kingdom)"},{"key":"10.25259\/SNI_1193_2021\/ref-3","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/BF00404100","article-title":"Magnetic resonance imaging of cerebral infarction: Time course of Gd-DTPA enhancement and CT comparison","volume":"30","author":"Imakita","year":"1988","journal-title":"Neuroradiology"},{"key":"10.25259\/SNI_1193_2021\/ref-4","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jacc.2016.04.044","article-title":"Dissection and aneurysm in patients with fibromuscular dysplasia: Findings from the U. S registry for FMD","volume":"68","author":"Kadian-Dodov","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.25259\/SNI_1193_2021\/ref-5","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1016\/j.amjcard.2018.12.045","article-title":"Prevalence, presentation, and associated conditions of patients with fibromuscular dysplasia","volume":"123","author":"Krittanawong","year":"2019","journal-title":"Am J Cardiol"},{"key":"10.25259\/SNI_1193_2021\/ref-6","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1161\/01.STR.13.1.46","article-title":"Fibromuscular dysplasia and the brain. I Observations on angiographic, clinical and genetic characteristics","volume":"13","author":"Mettinger","year":"1982","journal-title":"Stroke"},{"key":"10.25259\/SNI_1193_2021\/ref-7","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.jvs.2010.10.066","article-title":"Diagnosis, management, and future developments of fibromuscular dysplasia","volume":"53","author":"Olin","year":"2011","journal-title":"J Vasc Surg"},{"key":"10.25259\/SNI_1193_2021\/ref-8","doi-asserted-by":"crossref","first-page":"540","DOI":"10.2176\/nmc.44.540","article-title":"Intracranial atypical fibromuscular dysplasia with ruptured aneurysm--case report","volume":"44","author":"Ooba","year":"2004","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"10.25259\/SNI_1193_2021\/ref-9","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1161\/01.STR.8.5.617","article-title":"Angiographic spectrum of cervical and intracranial fibromuscular dysplasia","volume":"8","author":"Osborn","year":"1977","journal-title":"Stroke"},{"key":"10.25259\/SNI_1193_2021\/ref-10","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/cvr\/cvaa102","article-title":"The European\/ international fibromuscular dysplasia registry and initiative (FEIRI) clinical phenotypes and their predictors based on a cohort of 1000 patients","volume":"117","author":"Pappaccogli","year":"2021","journal-title":"Cardiovasc Res"},{"key":"10.25259\/SNI_1193_2021\/ref-11","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.neurol.2015.02.011","article-title":"Fibromuscular dysplasia of cervicocephalic arteries: Prevalence of multisite involvement and prognosis","volume":"171","author":"Pasquini","year":"2015","journal-title":"Rev Neurol (Paris)"},{"key":"10.25259\/SNI_1193_2021\/ref-12","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1097\/HJH.0000000000000213","article-title":"European consensus on the diagnosis and management of fibromuscular dysplasia","volume":"32","author":"Persu","year":"2014","journal-title":"J Hypertens"},{"key":"10.25259\/SNI_1193_2021\/ref-13","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s002340050421","article-title":"MRI of high-grade glial tumors: Correlation between the degree of contrast enhancement and the volume of surrounding edema","volume":"39","author":"Pronin","year":"1997","journal-title":"Neuroradiology"},{"key":"10.25259\/SNI_1193_2021\/ref-14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1369\/jhc.4A6514.2005","article-title":"Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues","volume":"54","author":"Pusztaszeri","year":"2006","journal-title":"J Histochem Cytochem"},{"key":"10.25259\/SNI_1193_2021\/ref-15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10456-010-9174-0","article-title":"Magnetic resonance imaging of brain angiogenesis after stroke","volume":"13","author":"Seevinck","year":"2010","journal-title":"Angiogenesis"},{"key":"10.25259\/SNI_1193_2021\/ref-16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.7887\/jcns.2.23","article-title":"Gadolimium-DTPA-enhanced MR imaging of cerebral infections","volume":"2","author":"Shibata","year":"1993","journal-title":"Jpn J Neurosurg"},{"key":"10.25259\/SNI_1193_2021\/ref-17","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1056\/NEJMra032393","article-title":"Fibromuscular dysplasia","volume":"350","author":"Slovut","year":"2004","journal-title":"N Engl J Med"},{"key":"10.25259\/SNI_1193_2021\/ref-18","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2214\/ajr.153.1.141","article-title":"Angiogenesis and blood-brain barrier breakdown modulate CT contrast enhancement: An experimental study in a rabbit brain-tumor model","volume":"153","author":"Zagzag","year":"1989","journal-title":"Am J Roentgenol"},{"key":"10.25259\/SNI_1193_2021\/ref-19","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cell.2015.10.067","article-title":"Establishment and dysfunction of the blood-brain barrier","volume":"163","author":"Zhao","year":"2015","journal-title":"Cell"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/a-case-of-fibromuscular-dysplasia-related-intracerebral-hemorrhage-without-angiographically-cerebral-abnormal-vessels\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/a-case-of-fibromuscular-dysplasia-related-intracerebral-hemorrhage-without-angiographically-cerebral-abnormal-vessels\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T11:01:01Z","timestamp":1642676461000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/a-case-of-fibromuscular-dysplasia-related-intracerebral-hemorrhage-without-angiographically-cerebral-abnormal-vessels\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,20]]},"references-count":19,"alternative-id":["10.25259\/SNI_1193_2021"],"URL":"https:\/\/doi.org\/10.25259\/sni_1193_2021","relation":{},"ISSN":["2152-7806"],"issn-type":[{"value":"2152-7806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,20]]},"article-number":"26"}}