{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T11:40:37Z","timestamp":1704973237523},"reference-count":19,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Astroblastoma is a rare primary brain tumor of unclear origin, often occurring in young patients less than 30-years-old. It typically arises supratentorially and is diagnosed based on histological features including vascular hyalinization and perivascular pseudorosettes. Recent molecular characterization of primary CNS high-grade neuroepithelial tumors with meningioma I alteration (HGNET-<jats:italic>MN1<\/jats:italic>) found that HGNET-<jats:italic>MN1<\/jats:italic> and tumors with morphological signatures of astroblastoma clustered together. Further analysis revealed such astroblastomas have <jats:italic>MN1<\/jats:italic> alteration and the 2021 WHO classification of tumors of the CNS now recognizes astroblastoma <jats:italic>MN1-<\/jats:italic>altered as a new entity.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>Here, we present the case of a 36-year-old right-handed woman with recurrent low-grade astroblastoma in the cervicomedullary junction. The patient presented with worsening motor and sensory deficits of her upper extremities, pain, ataxia, visual disturbance, and nausea. Due to extensive recurrence and neurological symptoms, the patient underwent reoperation.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>We review a rare case of recurrent astroblastoma in the foramen magnum in light of new relevant literature about tumor biology and prognostic significance of the new classification of astroblastoma <jats:italic>MN1<\/jats:italic>-altered.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_1208_2021","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T11:25:58Z","timestamp":1650021958000},"page":"139","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Recurrent HGNET-MN1 altered (astroblastoma MN1-altered) of the foramen magnum: Case report and molecular classification"],"prefix":"10.25259","volume":"13","author":[{"given":"Sricharan","family":"Gopakumar","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Baylor College of Medicine,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm F.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Baylor College of Medicine,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himanshu","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Baylor College of Medicine,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio E.","family":"Tatsui","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, University of Texas MD Anderson Cancer Center, Houston, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory N.","family":"Fuller","sequence":"additional","affiliation":[{"name":"Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganesh","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Baylor College of Medicine,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"10.25259\/SNI_1208_2021\/ref-1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/B978-0-323-44941-0.00009-6","article-title":"Other glial neoplasms","volume-title":"Practical Surgical Neuropathology: A Diagnostic Approach","author":"Brat","year":"2018","edition":"2nd ed"},{"key":"10.25259\/SNI_1208_2021\/ref-2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10014-020-00372-0","article-title":"Central nervous system neuroepithelial tumors with MN1-alteration: An individual patient data meta-analysis of 73 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