{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:55:07Z","timestamp":1787025307818,"version":"build-2736575974"},"reference-count":19,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Glioblastoma (GBM) may occasionally present with prominent vascular features that mimic an arteriovenous malformation (AVM), leading to diagnostic and therapeutic challenges. Pseudo-AVM GBMs are rare, and their recognition is essential to avoid misdiagnosis and inappropriate management.<\/jats:p>\n <\/jats:sec>\n \n Case Description:<\/jats:title>\n We report a 67-year-old male with a 2-month history of progressive headache, memory impairment, and speech difficulties. Neurological examination demonstrated mild right-sided limb weakness, homonymous hemianopsia, and expressive aphasia. Brain magnetic resonance imaging (MRI), computed tomography angiography, and digital subtraction angiography revealed a left temporal GBM with AVM-like vascular features. Arterial spin labeling (ASL) perfusion MRI revealed marked hyperperfusion and early venous drainage, providing noninvasive confirmation of tumor-related shunting. To reduce intraoperative bleeding risk, partial preoperative embolization of feeding arteries from the middle cerebral artery was performed, followed by gross total microsurgical resection. Histopathological examination demonstrated a hypervascular GBM, isocitrate dehydrogenase (IDH)-wildtype, with microvascular proliferation and necrosis confirmed by immunohistochemistry and polymerase chain reaction. Postoperative recovery was uneventful, and adjuvant chemoradiation according to the Stupp protocol was recommended.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n This case highlights pseudo-AVM GBM as a diagnostic and therapeutic challenge and demonstrates the value of ASL perfusion MRI and presurgical embolization in selected hypervascular tumors.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_1267_2025","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T13:33:12Z","timestamp":1774013592000},"page":"167","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Glioblastoma with pseudo-arteriovenous malformation features: Combined arterial spin-labeling assessment and preoperative embolization"],"prefix":"10.25259","volume":"17","author":[{"given":"Elena","family":"Filimonova","sequence":"first","affiliation":[{"name":"Department of Radiology, Federal Neurosurgical Center, Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Trukhachev","sequence":"additional","affiliation":[{"name":"Department of Radiology, Federal Neurosurgical Center, Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Kalinovsky","sequence":"additional","affiliation":[{"name":"Department of Neuro-Oncology, Federal Neurosurgical Center, Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artem","family":"Perfilev","sequence":"additional","affiliation":[{"name":"Department of Vascular, Federal Neurosurgical Center, Novosibirsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Sosnov","sequence":"additional","affiliation":[{"name":"Department of Vascular, Federal Neurosurgical Center, Novosibirsk, 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