{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:03:19Z","timestamp":1768820599289,"version":"3.49.0"},"reference-count":33,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background<\/jats:title>\n<jats:p>Craniopharyngiomas are benign epithelial tumors that arise along the craniopharyngeal duct, commonly located in the sellar or suprasellar region. Infrasellar extension is a rare variant and may involve the nasopharynx, sphenoid sinus, clivus, and pterygopalatine fossa.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description<\/jats:title>\n<jats:p>A 66-year-old male patient is presented to the otorhinolaryngology service due to a complaint of left ear obstruction for the past 4 months. After no response to clinical treatment, investigation with computed tomography and magnetic resonance imaging showed a heterogeneous lesion with areas of calcification and bone destruction located in the sphenoid sinus region, which projected inferiorly and laterally invading the clivus in its entirety, the petrous apex, middle fossa, pterygopalatine, and infratemporal fossae with no involvement of the sellar\/suprasellar region. The patient was referred to a multidisciplinary skull base surgery group that performed an extended transpterygoid endoscopic endonasal approach with gross total resection. The anatomopathological study was consistent with adamantinomatous craniopharyngioma.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>We present a rare case of a giant infrasellar craniopharyngioma with extensive invasion of the skull base without involvement of the sella or the pituitary gland.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_134_2025","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T10:14:53Z","timestamp":1746180893000},"page":"161","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A rare case of giant infrasellar craniopharyngioma with extensive invasion of the pterygopalatine fossa: A case report and literature review"],"prefix":"10.25259","volume":"16","author":[{"given":"Vittor S\u00e9rgio Santos de","family":"Quintela","sequence":"first","affiliation":[{"name":"Department of Medicine, Federal University of Sergipe, Aracaju, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia Morais Silva","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Medicine, Federal University of Sergipe, Aracaju, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur Campos do","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Department of Medicine, Federal University of Sergipe, Aracaju, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson Almeida D\u2019\u00c1vila","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Universidade Tiradentes, Aracaju, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur Maynart Pereira","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital de Cirurgia, Aracaju, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"10.25259\/SNI_134_2025\/ref-1","doi-asserted-by":"crossref","first-page":"618.e7","DOI":"10.1016\/j.wneu.2016.08.044","article-title":"Expanded endonasal endoscopic approach for resection of an infrasellar craniopharyngioma","volume":"95","author":"Abou-Al-Shaar","year":"2016","journal-title":"World Neurosurg"},{"key":"10.25259\/SNI_134_2025\/ref-2","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1258\/0022215042703688","article-title":"Infrasellar craniopharyngioma presenting as epistaxis, excised via denker\u2019s medial maxillectomy approach","volume":"118","author":"Ahsan","year":"2004","journal-title":"J Laryngol Otol"},{"key":"10.25259\/SNI_134_2025\/ref-3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF00698851","article-title":"Infrasellar craniopharyngioma","volume":"31","author":"Akimura","year":"1989","journal-title":"Neuroradiology"},{"key":"10.25259\/SNI_134_2025\/ref-4","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.otohns.2007.06.734","article-title":"Entire infrasellar craniopharyngioma simulating clival chordoma","volume":"137","author":"Arndt","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.25259\/SNI_134_2025\/ref-5","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.nec.2015.03.013","article-title":"Endoscopic endonasal approach for craniopharyngiomas","volume":"26","author":"Baldauf","year":"2015","journal-title":"Neurosurg Clin N Am"},{"key":"10.25259\/SNI_134_2025\/ref-6","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1097\/00004728-198811000-00034","article-title":"Craniopharyngioma presenting as a nasopharyngeal mass: CT and MR findings","volume":"12","author":"Benitez","year":"1988","journal-title":"J Comput Assist Tomogr"},{"key":"10.25259\/SNI_134_2025\/ref-7","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s007010100026","article-title":"Nasopharyngeal extension of a craniopharyngioma in a 4 year old girl","volume":"143","author":"Buhl","year":"2001","journal-title":"Acta Neurochir (Wien)"},{"key":"10.25259\/SNI_134_2025\/ref-8","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1177\/000348949009900809","article-title":"Nasopharyngeal craniopharyngioma. 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