{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T03:13:03Z","timestamp":1780715583908,"version":"3.54.1"},"reference-count":13,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"Background:<\/jats:title>Primary spinal glioblastomas are extremely rare neoplasms and account for only 0.2% of glioblastoma cases. Due to the rare incidence of spinal cord glioblastoma in the literature, its natural history\/ outcome remains undetermined. The present article describes the clinical presentation, radiological\/pathological characteristics, and outcome of the primary spinal cord glioblastoma.<\/jats:p><\/jats:sec>Case Description:<\/jats:title>Two young patients initially presented with paresis that rapidly progressed to paraplegia. Nondermatomal sensory deficits were also noted, mainly affecting the lower limbs. Neuroradiological imaging revealed an extensive intramedullary spinal cord lesion, with no evidence of concurrent intracranial space-occupying lesions. Thoracic laminectomy, followed by tumor debulking and\/or biopsy, was performed. The histomorphology was suggestive of glioblastoma, the World Health Organization grade 4 (Isocitrate Dehydrogenase-wild type). They were discharged in stable condition and were started on chemoradiotherapy, with clinicoradiological follow-up. One patient passed away after 9 months of initial presentation. The other patient was alive at 6-month follow-up.<\/jats:p><\/jats:sec>Conclusion:<\/jats:title>Primary spinal glioblastoma is a rare and challenging tumor. Patients commonly present with a progressive paresis, resulting in paraplegia, regardless of the surgical resection extent, and received adjuvant chemotherapy. Therefore, primary spinal cord glioblastoma should be considered in patients reporting a rapid lower limb weakness with neuroradiological evidence of extensive, exophytic intramedullary lesion of the spine. A biopsy-proven histopathological diagnosis is of indisputable importance to establish the final diagnosis and plan treatment options.<\/jats:p><\/jats:sec>","DOI":"10.25259\/sni_135_2022","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T10:58:18Z","timestamp":1650625098000},"page":"160","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Primary spinal cord glioblastoma: A rare cause of paraplegia"],"prefix":"10.25259","volume":"13","author":[{"given":"Bashaer","family":"Alharbi","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia."},{"name":"College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia."},{"name":"King Abdullah International Medical Research Center, Riyadh, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajar","family":"Alammar","sequence":"additional","affiliation":[{"name":"Saudi Ministry of Health, Third Healthcare Cluster, Riyadh, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Alkhaibary","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, King Abdulaziz Medical City, Ministry of National Guard - 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