{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T09:29:40Z","timestamp":1775813380558,"version":"3.50.1"},"reference-count":24,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n \n Brain abscesses are serious, life-threatening infections that require prompt diagnosis and treatment. Although\n Actinomyces<\/jats:italic>\n species are recognized causes of brain abscesses, infections caused by\n Actinomyces urogenitalis<\/jats:italic>\n and\n Peptoniphilus asaccharolyticus<\/jats:italic>\n are exceptionally rare and, to our knowledge, have not been previously reported.\n <\/jats:p>\n <\/jats:sec>\n \n Case Description:<\/jats:title>\n \n We describe a 62-year-old man with a long history of chronic bilateral otitis media who presented with progressive vertigo, severe hemicranial headache, nausea, and vomiting. Within hours of admission, his neurological status worsened, leading to urgent neuroimaging that revealed a right temporal brain abscess associated with subfalcine herniation. The patient underwent emergent craniotomy with abscess drainage. Microbiological cultures identified\n A. urogenitalis<\/jats:italic>\n and\n P. asaccharolyticus<\/jats:italic>\n . He was treated with prolonged intravenous antibiotics followed by oral therapy, achieving complete clinical recovery and full radiological resolution of the lesion.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n This report documents the first known case of a brain abscess caused by\n A. urogenitalis<\/jats:italic>\n and\n P. asaccharolyticus<\/jats:italic>\n . The case emphasizes the importance of considering unusual pathogens in brain abscesses and highlights the value of early surgical management combined with targeted, long-term antimicrobial therapy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_1363_2025","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T08:30:55Z","timestamp":1775809855000},"page":"213","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Actinomyces urogenitalis<\/i>\n and\n Peptoniphilus asaccharolyticus<\/i>\n brain abscess in an immunocompetent patient: A case report"],"prefix":"10.25259","volume":"17","author":[{"given":"Sergio Esteban","family":"Chac\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Isabel","family":"Ocampo-Navia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Casta\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Vergara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2026,4,10]]},"reference":[{"key":"10.25259\/SNI_1363_2025\/ref-1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1034\/j.1399-0012.2002.02033.x","article-title":"Fungal brain abscess in transplant recipients: Epidemiologic, microbiologic, and clinical features","volume":"16","author":"Baddley","year":"2002","journal-title":"Clin Transplant"},{"key":"10.25259\/SNI_1363_2025\/ref-2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jgar.2016.11.007","article-title":"Antimicrobial susceptibility of clinical isolates of Actinomyces and related genera reveals an unusual clindamycin resistance among Actinomyces urogenitalis strains","volume":"8","author":"Barberis","year":"2017","journal-title":"J Glob Antimicrob Resist"},{"key":"10.25259\/SNI_1363_2025\/ref-3","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cmi.2023.08.016","article-title":"European society of clinical microbiology and infectious diseases guidelines on diagnosis and treatment of brain abscess in children and adults","volume":"30","author":"Bodilsen","year":"2024","journal-title":"Clin Microbiol Infect"},{"key":"10.25259\/SNI_1363_2025\/ref-4","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/cid\/ciz890","article-title":"Risk factors for brain abscess: A nationwide, population-based, nested case-control study","volume":"71","author":"Bodilsen","year":"2020","journal-title":"Clin Infect Dis"},{"key":"10.25259\/SNI_1363_2025\/ref-5","doi-asserted-by":"crossref","first-page":"O857","DOI":"10.1111\/1469-0691.12657","article-title":"Bloodstream infections due to Peptoniphilus spp.: Report of 15 cases","volume":"20","author":"Brown","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"10.25259\/SNI_1363_2025\/ref-6","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1056\/NEJMra1301635","article-title":"Brain abscess","volume":"371","author":"Brouwer","year":"2014","journal-title":"N Engl J Med"},{"key":"10.25259\/SNI_1363_2025\/ref-7","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12879-024-08995-w","article-title":"Brain abscess caused by Actinomyces turicensis in a non-immunocompromised adult patient: A case report and systematic review of the literature","volume":"24","author":"Imeneo","year":"2024","journal-title":"BMC Infect Dis"},{"key":"10.25259\/SNI_1363_2025\/ref-8","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3109\/23744235.2015.1113557","article-title":"Intracranial abscesses over the last four decades; changes in aetiology, diagnostics, treatment and outcome","volume":"48","author":"Laulajainen-Hongisto","year":"2016","journal-title":"Infect Dis (Lond)"},{"key":"10.25259\/SNI_1363_2025\/ref-9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.4067\/S0716-10182011000500009","article-title":"Actinomyces urogenitalis","volume":"28","author":"Mart\u00ednez","year":"2011","journal-title":"Rev Chilena Infectol"},{"key":"10.25259\/SNI_1363_2025\/ref-10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.anaerobe.2019.07.001","article-title":"Peptoniphilus asaccharolyticuscommensal, pathogen or synergist? 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