{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:37:05Z","timestamp":1771511825927,"version":"3.50.1"},"reference-count":11,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nNervous system involvement in immunoglobulin G4-related disease (IgG4-RD) has been rarely reported.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nWe describe an unusual case of IgG4-RD manifested as paresthesia in the right lower extremity. A 51-year-old male presented with paresthesia in the right S1\u2013S3 regions. A neurological examination revealed peripheral neuropathy. Blood examination results were normal, barring slightly elevated IgG levels. Initial magnetic resonance imaging of the swollen right S1 and S2 nerve roots revealed lymphoma, schwannoma, and sarcoidosis. However, following the biopsy, the pathological findings were not typical of these diseases. Abdominal computed tomography revealed perirenal lesions, and IgG4-RD was suspected. The patient had a serum IgG4 level of 724 mg\/dL. Additional pathological evaluations of the swollen S1 nerve revealed findings that corresponded to the diagnostic criteria for IgG4-RD. Oral steroid therapy was initiated, which improved paresthesia, and the swollen S1 nerve root gradually shrank.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nThis report highlights a rare case of<\/jats:bold> IgG4-RD involving nerve roots that neurosurgeons should consider.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_157_2024","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:24:13Z","timestamp":1718349853000},"page":"197","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Immunoglobulin G4-related disease manifesting as peripheral neuropathy: A rare clinical symptom due to rare autoimmune disease"],"prefix":"10.25259","volume":"15","author":[{"given":"Tamaki","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Department of Spinal Neurosurgery, Kyoto-Katsura Hospital, Kyoto, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yosinori","family":"Maki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hikone Chuo Hospital, Hikone, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kurashiki Central Hospital, Kurashiki, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaomi","family":"Koyanagi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kobe City Medical Center General Hospital, Kobe City, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Oda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Japanease Red Cross Otsu Hospital, Otsu, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Saiki","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Japanease Red Cross Otsu Hospital, Otsu, Japan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"10.25259\/SNI_157_2024\/ref-1","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/modpathol.2012.72","article-title":"Consensus statement on the pathology of IgG4-related disease","volume":"25","author":"Deshpande","year":"2012","journal-title":"Mod Pathol"},{"key":"10.25259\/SNI_157_2024\/ref-2","doi-asserted-by":"crossref","first-page":"401890","DOI":"10.1155\/2012\/401890","article-title":"IgG4-related perineural disease","volume":"2012","author":"Inoue","year":"2012","journal-title":"Int J Rheumatol"},{"key":"10.25259\/SNI_157_2024\/ref-3","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1002\/art.39132","article-title":"International consensus guidance statement on the management and treatment of IgG4-related disease","volume":"67","author":"Khosroshahi","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.25259\/SNI_157_2024\/ref-4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2176\/nmccrj.cr.2020-0067","article-title":"Spinal bony involvement of IgG4-related disease treated by a spondylectomy","volume":"8","author":"Kim","year":"2021","journal-title":"NMC Case Rep J"},{"key":"10.25259\/SNI_157_2024\/ref-5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2147\/BLCTT.S142814","article-title":"Plasmablastic lymphoma: Current perspectives","volume":"8","author":"Lopez","year":"2018","journal-title":"Blood Lymphat Cancer"},{"key":"10.25259\/SNI_157_2024\/ref-6","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3171\/2016.4.SPINE1674","article-title":"An orphan disease: IgG4-related spinal pachymeningitis: Report of 2 cases","volume":"25","author":"Radotra","year":"2016","journal-title":"J Neurosurg Spine"},{"key":"10.25259\/SNI_157_2024\/ref-7","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3171\/2016.11.SPINE16924","article-title":"Immunoglobulin G4-related epidural inflammatory pseudotumor presenting with pulmonary complications and spinal cord compression: Case report","volume":"26","author":"Rumalla","year":"2017","journal-title":"J Neurosurg Spine"},{"key":"10.25259\/SNI_157_2024\/ref-8","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1056\/NEJMra1104650","article-title":"IgG4-related disease","volume":"366","author":"Stone","year":"2012","journal-title":"N Engl J Med"},{"key":"10.25259\/SNI_157_2024\/ref-9","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/14397595.2020.1859710","article-title":"The 2020 revised comprehensive diagnostic (RCD) criteria for IgG4-RD","volume":"31","author":"Umehara","year":"2021","journal-title":"Mod Rheumatol"},{"key":"10.25259\/SNI_157_2024\/ref-10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3171\/2016.5.SPINE16119","article-title":"Immunoglobulin G4-related disease mimicking an epidural spinal cord tumor: Case report","volume":"26","author":"Williams","year":"2017","journal-title":"J Neurosurg Spine"},{"key":"10.25259\/SNI_157_2024\/ref-11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4103\/sni.sni_156_18","article-title":"Neuro-surgical considerations for treating IgG4-related disease with rare spinal epidural compression","volume":"9","author":"Winkel","year":"2018","journal-title":"Surg Neurol Int"}],"container-title":["Surgical Neurology 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