{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T09:52:40Z","timestamp":1781862760426,"version":"3.54.5"},"reference-count":11,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Pediatric brain tumors represent the leading cause of cancer-related mortality in children, with survival outcomes in low-middle-income countries (LMICs) significantly inferior to those in high-income countries. While survival data from LMICs are emerging, health-related quality of life (HRQOL) and functional outcomes remain poorly characterized. This study aimed to evaluate HRQOL and identify predictors of functional outcomes in pediatric brain tumor survivors at a tertiary care center in India.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A retrospective cohort study was conducted on pediatric brain tumor patients (age 2\u201318 years) treated between January 2019 and December 2023 at our tertiary care center. For the present analysis, we included 92 children who were alive and in active follow-up for at least 12 months after completion of primary treatment and were therefore considered survivors. The Pediatric Quality of Life Inventory (PedsQL) Brain Tumor Module and Lansky Performance Scale were administered at the time of the last follow-up visit (minimum 12 months post-treatment). Clinical variables, including tumor histology, location, treatment modality, complications, and late effects, were extracted, and univariate and multivariate regression were used to identify predictors of HRQOL.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Among these 92 survivors, the mean follow-up duration was 32.4 months (range 12\u201358 months). In the initial cohort of 134 children, 58.7% were alive at last follow-up. Mean total PedsQL score was 64.3 \u00b1 18.2. Cognitive functioning (56.8 \u00b1 21.4) and procedural anxiety (58.2 \u00b1 19.6) subscales scored lowest. Multivariate analysis revealed that supratentorial tumor location (\u03b2 = \u221212.4,\n p<\/jats:italic>\n = 0.002), disease recurrence (\u03b2 = \u221215.8,\n p<\/jats:italic>\n < 0.001), craniospinal radiation (\u03b2 = \u221211.2,\n p<\/jats:italic>\n = 0.004), and postoperative complications (\u03b2 = \u22129.6,\n p<\/jats:italic>\n = 0.012) were independent predictors of poor HRQOL. Gross total resection predicted better outcomes (\u03b2 = 8.7,\n p<\/jats:italic>\n = 0.008).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Pediatric brain tumor survivors in LMICs demonstrate impaired HRQOL, particularly in cognitive and emotional domains. Tumor location, treatment-related toxicity, and extent of resection significantly impact long-term outcomes. These findings emphasize the need for comprehensive survivorship programs and neurocognitive rehabilitation strategies in resource-limited settings.<\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_161_2026","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:58:12Z","timestamp":1781859492000},"page":"358","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quality of life and functional outcomes in pediatric brain tumor survivors in resource-limited settings: A retrospective cohort study"],"prefix":"10.25259","volume":"17","author":[{"given":"Kanav","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, All India Institute of Medical Sciences,Vijaypur, Jammu, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivanya","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"10.25259\/SNI_161_2026\/ref-1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3389\/fpsyg.2018.00703","article-title":"Neuropsychological consequences for survivors of childhood brain tumor in Malaysia","volume":"9","author":"Alias","year":"2018","journal-title":"Front Psychol"},{"key":"10.25259\/SNI_161_2026\/ref-2","first-page":"1662","article-title":"Pediatric oncology in countries with limited resources","volume-title":"Nathan and Oski\u2019s Hematology and Oncology of Infancy and Childhood","author":"Barr","year":"2015","edition":"8th ed"},{"key":"10.25259\/SNI_161_2026\/ref-3","first-page":"82","article-title":"Health-related quality of life of pediatric brain tumor survivors after treatment in Jordan","volume":"11","author":"Choi","year":"2024","journal-title":"Neurooncol Pract"},{"key":"10.25259\/SNI_161_2026\/ref-4","first-page":"1","article-title":"Worldwide trends in survival from common childhood brain tumors: A systematic review","volume":"5","author":"Girardi","year":"2019","journal-title":"J Glob Oncol"},{"key":"10.25259\/SNI_161_2026\/ref-5","first-page":"121","article-title":"Treating childhood cancer in low- and middle-income countries","volume-title":"Cancer: Disease Control Priorities","volume":"3","author":"Gupta","year":"2015","edition":"3rd ed"},{"key":"10.25259\/SNI_161_2026\/ref-6","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1200\/JCO.2012.47.8867","article-title":"Association between the prevalence of symptoms and health-related quality of life in adult survivors of childhood cancer: A report from the St Jude Lifetime Cohort study","volume":"31","author":"Huang","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.25259\/SNI_161_2026\/ref-7","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1002\/1097-0142(19871001)60:7<1651::AID-CNCR2820600738>3.0.CO;2-J","article-title":"The measurement of performance in childhood cancer patients","volume":"60","author":"Lansky","year":"1987","journal-title":"Cancer"},{"key":"10.25259\/SNI_161_2026\/ref-8","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S1470-2045(11)70128-0","article-title":"Abandonment of treatment for childhood cancer: Position statement of a SIOP PODC working group","volume":"12","author":"Mostert","year":"2011","journal-title":"Lancet Oncol"},{"key":"10.25259\/SNI_161_2026\/ref-9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S1470-2045(04)01507-4","article-title":"Late neurocognitive sequelae in survivors of brain tumours in childhood","volume":"5","author":"Mulhern","year":"2004","journal-title":"Lancet Oncol"},{"issue":"12","key":"10.25259\/SNI_161_2026\/ref-10","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/noad149","article-title":"CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2016-2020","volume":"25","author":"Ostrom","year":"2023","journal-title":"Neuro Oncol"},{"key":"10.25259\/SNI_161_2026\/ref-11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/pbc.21026","article-title":"The PedsQL brain tumor module: Initial reliability and validity","volume":"49","author":"Palmer","year":"2007","journal-title":"Pediatr Blood Cancer"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/quality-of-life-and-functional-outcomes-in-pediatric-brain-tumor-survivors-in-resource-limited-settings-a-retrospective-cohort-study\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/quality-of-life-and-functional-outcomes-in-pediatric-brain-tumor-survivors-in-resource-limited-settings-a-retrospective-cohort-study\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:58:15Z","timestamp":1781859495000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/quality-of-life-and-functional-outcomes-in-pediatric-brain-tumor-survivors-in-resource-limited-settings-a-retrospective-cohort-study\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":11,"alternative-id":["10.25259\/SNI_161_2026"],"URL":"https:\/\/doi.org\/10.25259\/sni_161_2026","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"article-number":"358"}}