{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T22:01:17Z","timestamp":1773612077370,"version":"3.50.1"},"reference-count":18,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Intracranial metastatic deposits due to hepatocellular carcinoma (HCC) are rare. Only a few cases are reported in the literature. These may be more likely to come to clinical attention than extrahepatic metastases in other sites since they often produce symptoms that necessitate neurosurgical intervention.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>We report a case of a 53-year-old male with biopsy-proven intracranial skull base metastasis from HCC as an unusual initial presentation of the disease and review the relevant literature on this entity.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>Intracranial metastasis of HCC should be included in the differential diagnosis of rapidly growing metastatic lesions in unusual locations, particularly in chronic liver disease and hepatitis B surface antigen-positive or hepatitis C patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_166_2023","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T05:38:07Z","timestamp":1693546687000},"page":"297","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Skull base metastasis as initial presentation of hepatocellular carcinoma"],"prefix":"10.25259","volume":"14","author":[{"given":"Raima","family":"Zakaria","sequence":"first","affiliation":[{"name":"Department of Radiology, Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatima","family":"Mubarak","sequence":"additional","affiliation":[{"name":"Department of Radiology, Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumail","family":"Khandwala","sequence":"additional","affiliation":[{"name":"Department of Radiology, Aga Khan University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha","family":"Memon","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2023,8,25]]},"reference":[{"key":"10.25259\/SNI_166_2023\/ref-1","first-page":"91","article-title":"Brain metastasis from hepatocellular carcinoma after radical hepatectomy","volume":"48","author":"Asahara","year":"1999","journal-title":"Hiroshima J Med Sci"},{"key":"10.25259\/SNI_166_2023\/ref-2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.surneu.2003.10.002","article-title":"Intracranial metastasis of hepatocellular carcinoma: Review of 45 cases","volume":"62","author":"Chang","year":"2004","journal-title":"Surg Neurol"},{"key":"10.25259\/SNI_166_2023\/ref-3","first-page":"331","article-title":"Combined chronic 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