{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T02:49:42Z","timestamp":1767494982852},"reference-count":12,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nThe objective was to study the effectiveness and diagnostic outcome of frame-based stereotactic brain biopsy (STB) done for contrast non-enhancing lesions using indirect evidence of target selection observed in a plain computed tomography (CT) scan of the head.<\/jats:p>\n<\/jats:sec>\n\nMethods: <\/jats:title>\nData of patients with contrast non-enhancing brain lesions who underwent STB are collected retrospectively from NIMHANS Bangalore, hospital neurosurgery database from January 2021 to March 2023. Those cases subjected to plain CT scans after fixing the stereotactic frame to the head were included in the study. A final histopathological report analysis of these cases was done to assess the diagnostic accuracy.<\/jats:p>\n<\/jats:sec>\n\nResults: <\/jats:title>\nA total of 27 such cases were biopsied. The mean age of subjects was 44.04 \u00b1 17.812 years. Most subjects were in the age group 31\u201340 years (29.6%). About 55.6% were male and 44.4% were female. The most common site of biopsy was the frontal lobe. The most common indirect evidence on CT was perilesional edema at 33.3% and periventricular location at 33.3%, followed by intralesional calcification at 11.1%. Our diagnostic accuracy was 92.59%. The asymptomatic hemorrhage rate was 2%, and an increase in perilesional edema was seen in 2% of cases.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nIndirect targeting is a safe and intuitive method for biopsy of contrast non-enhancing lesions. Due consideration is to be given to various findings visible in non-contrast CT scans of the head as indirect evidence of target selection while performing frame-based STB of contrast non-enhancing lesions. This method will also be helpful in resource-limited centers, especially in low-income countries.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_187_2024","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T11:10:21Z","timestamp":1723806621000},"page":"286","update-policy":"http:\/\/dx.doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Computed tomography-guided frame-based stereotactic brain biopsy of non-enhancing lesions using indirect evidence of target selection, technical consideration, and early clinical experience"],"prefix":"10.25259","volume":"15","author":[{"given":"TS","family":"Lingaraju","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, NIMHANS, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AR","family":"Prabhuraj","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NIMHANS, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BN","family":"Nandeesh","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, NIMHANS, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jitender","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of NeuroImaging and Interventional Neuroradiology, NIMHANS, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nupur","family":"Pruthi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, NIMHANS, Bengaluru, Karnataka, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2024,8,16]]},"reference":[{"key":"10.25259\/SNI_187_2024\/ref-1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3389\/fonc.2019.00947","article-title":"Current trends for improving safety of stereotactic brain biopsies: Advanced optical methods for vessel avoidance and tumor detection","volume":"9","author":"Akshulakov","year":"2019","journal-title":"Front Oncol"},{"key":"10.25259\/SNI_187_2024\/ref-2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.clineuro.2009.03.006","article-title":"Spectroscopy-supported frame-based image-guided stereotactic biopsy of parenchymal brain lesions: Comparative evaluation of diagnostic yield and diagnostic accuracy","volume":"111","author":"Chernov","year":"2009","journal-title":"Clin Neurol Neurosurg"},{"key":"10.25259\/SNI_187_2024\/ref-3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.wneu.2019.04.016","article-title":"Comparison of frame-based versus frameless intracranial stereotactic biopsy: Systematic review and meta-analysis","volume":"127","author":"Dhawan","year":"2019","journal-title":"World Neurosurg"},{"key":"10.25259\/SNI_187_2024\/ref-4","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1007\/s00701-014-2073-1","article-title":"Molecular stereotactic biopsy technique improves diagnostic accuracy and enables personalized treatment strategies in glioma patients","volume":"156","author":"Eigenbrod","year":"2014","journal-title":"Acta Neurochir (Wien)"},{"key":"10.25259\/SNI_187_2024\/ref-5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.clineuro.2018.09.008","article-title":"Prognostic risk factors for postoperative hemorrhage in stereotactic biopsies of lesions in the basal ganglia","volume":"174","author":"Farahmand","year":"2018","journal-title":"Clin Neurol Neurosurg"},{"key":"10.25259\/SNI_187_2024\/ref-6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1055\/a-1994-8033","article-title":"Diagnostic accuracy and field for improvement of frameless stereotactic brain biopsy: A focus on nondiagnostic cases","volume":"85","author":"He","year":"2024","journal-title":"J Neurol Surg A Cent Eur Neurosurg"},{"key":"10.25259\/SNI_187_2024\/ref-7","first-page":"1151","article-title":"Stereotactic coregistration of 201Tl SPECT and MRI applied to brain tumor biopsies","volume":"46","author":"Hemm","year":"2005","journal-title":"J Nucl Med"},{"key":"10.25259\/SNI_187_2024\/ref-8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.25259\/SNI_824_2020","article-title":"Frame-based versus frameless stereotactic brain biopsies: A systematic review and meta-analysis","volume":"12","author":"Kesserwan","year":"2021","journal-title":"Surg Neurol Int"},{"key":"10.25259\/SNI_187_2024\/ref-9","first-page":"1293","article-title":"Comparison of 18F-FDG and 11C-methionine for PET-guided stereotactic brain biopsy of gliomas","volume":"45","author":"Pirotte","year":"2004","journal-title":"J Nucl Med"},{"key":"10.25259\/SNI_187_2024\/ref-10","first-page":"392","article-title":"Results of positron emission tomography guidance and reassessment of the utility of and indications for stereotactic biopsy in children with infiltrative brainstem tumors","volume":"107","author":"Pirotte","year":"2007","journal-title":"J Neurosurg"},{"key":"10.25259\/SNI_187_2024\/ref-11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3109\/02688697.2012.722239","article-title":"Factors affecting diagnostic yield in needle biopsy for brain lesions","volume":"27","author":"Tsermoulas","year":"2013","journal-title":"Br J Neurosurg"},{"key":"10.25259\/SNI_187_2024\/ref-12","article-title":"Youmans and Winn neurological surgery e-book","volume":"4","author":"Winn","year":"2022"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/computed-tomography-guided-frame-based-stereotactic-brain-biopsy-of-non-enhancing-lesions-using-indirect-evidence-of-target-selection-technical-consideration-and-early-clinical-experience\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/computed-tomography-guided-frame-based-stereotactic-brain-biopsy-of-non-enhancing-lesions-using-indirect-evidence-of-target-selection-technical-consideration-and-early-clinical-experience\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T11:10:27Z","timestamp":1723806627000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/computed-tomography-guided-frame-based-stereotactic-brain-biopsy-of-non-enhancing-lesions-using-indirect-evidence-of-target-selection-technical-consideration-and-early-clinical-experience\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,16]]},"references-count":12,"alternative-id":["10.25259\/SNI_187_2024"],"URL":"https:\/\/doi.org\/10.25259\/sni_187_2024","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,16]]},"article-number":"286"}}