{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T04:03:13Z","timestamp":1745640193936,"version":"3.40.4"},"reference-count":19,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background<\/jats:title>\n<jats:p>Temporal bone paragangliomas are complex pathologies presenting close relationships with many critical neurovascular structures. Exclusively, dopamine-secreting paragangliomas are rare and may present a major hemodynamic challenge during intraoperative and postoperative periods, with great blood pressure lability due to the dose-dependent properties of dopamine. However, preoperative \u03b1 or \u03b2 blockage is usually not advised. Microsurgical resection is the treatment of choice; nevertheless, these tumors commonly present with greater size at diagnosis due to their non-specific clinical manifestations.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description<\/jats:title>\n<jats:p>A 43-year-old male patient presented with headache, tinnitus, hearing loss, hypoglossal and facial nerve compromise, as well as vocal cord palsy. Magnetic resonance imaging depicted a giant posterior fossa mass centered in the left jugular foramen extending to the cervical space, associated with important bone erosion. Laboratory investigation depicted elevated serum dopamine concentration of &gt;2.500 pg\/mL (reference &lt;30 pg\/mL) and increased 24-h urine dosage of 3306 \u03bcg (reference &lt;540 \u03bcg). Values of epinephrine, norepinephrine, and metanephrines were within normal range. The patient underwent preoperative embolization, and microsurgical resection was performed the next day. Serum and urinary dopamine concentrations were normalized following the procedure. The patient presented a favorable outcome, with no new neurological deficits.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Exclusively dopamine-secreting temporal bone paragangliomas may be successfully resected with a favorable outcome. A multidisciplinary, well-trained team is essential to manage intraoperative challenges up to postoperative rehabilitation adequately. Extensive laboratory training is essential to develop the surgical skills to master this skull-based approach.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_188_2024","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T08:13:18Z","timestamp":1745568798000},"page":"147","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Microsurgical resection of a giant exclusively dopamine- secreting jugular foramen paraganglioma: A case report"],"prefix":"10.25259","volume":"16","author":[{"given":"Guilherme H. W.","family":"Ceccato","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Mackenzie Evangelical University Hospital, Curitiba, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falia S.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mackenzie Evangelical University Hospital, Curitiba, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro H.","family":"dos Santos Neto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mackenzie Evangelical University Hospital, Curitiba, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick. D.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mackenzie Evangelical University Hospital, Curitiba, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo A.","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mackenzie Evangelical University Hospital, Curitiba, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius N.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mackenzie Evangelical University Hospital, Curitiba, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitor P.","family":"Barreto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mackenzie Evangelical University Hospital, Curitiba, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo A. R.","family":"Passos","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mackenzie Evangelical University Hospital, Curitiba, Paran\u00e1, Brazil"},{"name":"CANES Laboratory, University of Miami, Miami, Florida, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo A. S.","family":"Kadri","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mackenzie Evangelical University Hospital, Curitiba, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean G","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis A. B.","family":"Borba","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mackenzie Evangelical University Hospital, Curitiba, Paran\u00e1, Brazil"},{"name":"Department of Neurosurgery, Federal University of Paran\u00e1, Curitiba, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"10.25259\/SNI_188_2024\/ref-1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.20344\/amp.17185","article-title":"Head and neck paragangliomas: The experience of a southern European cancer center","volume":"35","author":"Castelhano","year":"2022","journal-title":"Acta M\u00e9d Port"},{"key":"10.25259\/SNI_188_2024\/ref-2","doi-asserted-by":"crossref","first-page":"S385","DOI":"10.1055\/s-0039-1695055","article-title":"Microsurgical resection of multiple giant glomus tumors","volume":"80","author":"Ceccato","year":"2019","journal-title":"J Neurol Surg B Skull Base"},{"key":"10.25259\/SNI_188_2024\/ref-3","first-page":"e361","article-title":"Transmastoid\/infralabyrinthine approach to the jugular foramen: 2-dimensional operative video","volume":"25","author":"Ceccato","year":"2023","journal-title":"Oper Neurosurg"},{"key":"10.25259\/SNI_188_2024\/ref-4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/lio2.706","article-title":"Contemporary management of paragangliomas of the head and neck","volume":"7","author":"Cleere","year":"2022","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"10.25259\/SNI_188_2024\/ref-5","doi-asserted-by":"crossref","first-page":"5210","DOI":"10.1210\/jcem.86.11.8034","article-title":"Benign paragangliomas: Clinical presentation and treatment outcomes in 236 patients","volume":"86","author":"Erickson","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.25259\/SNI_188_2024\/ref-6","first-page":"e89","article-title":"Dopamine-secreting phaeochromocytomas and paragangliomas: Clinical features and management","volume":"51","author":"Foo","year":"2010","journal-title":"Singapore Med J"},{"key":"10.25259\/SNI_188_2024\/ref-7","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.mpdhp.2014.06.002","article-title":"Head and neck paragangliomas: What does the pathologist need to know?","volume":"20","author":"Hayashi","year":"2014","journal-title":"Diagn Histopathol"},{"key":"10.25259\/SNI_188_2024\/ref-8","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1002\/hed.24871","article-title":"Feasibility of a wait-and-scan period as initial management strategy for head and neck paraganglioma","volume":"39","author":"Jansen","year":"2017","journal-title":"Head Neck"},{"key":"10.25259\/SNI_188_2024\/ref-9","doi-asserted-by":"crossref","first-page":"e210088","DOI":"10.1148\/rycan.210088","article-title":"Head and neck paragangliomas: An update on the molecular classification, state-of-the-art imaging, and management recommendations","volume":"4","author":"Lin","year":"2022","journal-title":"Radiol Imaging Cancer"},{"key":"10.25259\/SNI_188_2024\/ref-10","first-page":"123","article-title":"Update from the 5th edition of the world health organization classification of head and neck tumors: Overview of the 2022 WHO classification of head and neck neuroendocrine neoplasms","volume-title":"Head Neck Pathol","volume":"16","author":"Mete","year":"2022"},{"key":"10.25259\/SNI_188_2024\/ref-11","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4158\/EP161377.OR","article-title":"Growth rate of paragangliomas related to germline mutations of the SDHX genes","volume":"23","author":"Micha\u0142owska","year":"2017","journal-title":"Endocr Pract"},{"key":"10.25259\/SNI_188_2024\/ref-12","doi-asserted-by":"crossref","first-page":"bvab163","DOI":"10.1210\/jendso\/bvab163","article-title":"Dopamine-secreting pheochromocytoma and paraganglioma","volume":"5","author":"Miyamoto","year":"2021","journal-title":"J Endocr Soc"},{"key":"10.25259\/SNI_188_2024\/ref-13","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.oraloncology.2003.09.004","article-title":"Paragangliomas of the head and neck","volume":"40","author":"Pellitteri","year":"2004","journal-title":"Oral Oncol"},{"key":"10.25259\/SNI_188_2024\/ref-14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.15586\/paraganglioma.2019.ch6","article-title":"Tympanojugular paragangliomas: Surgical management and clinicopathological features","volume-title":"Paraganglioma: A multidisciplinary approach","author":"Prasad","year":"2019"},{"key":"10.25259\/SNI_188_2024\/ref-15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.eprac.2022.10.002","article-title":"Paraganglioma of the head and neck: A review","volume":"29","author":"Sandow","year":"2023","journal-title":"Endocr Pract"},{"key":"10.25259\/SNI_188_2024\/ref-16","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S2213-8587(23)00038-4","article-title":"Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants","volume":"11","author":"Ta\u00efeb","year":"2023","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.25259\/SNI_188_2024\/ref-17","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s12105-017-0803-4","article-title":"Paragangliomas of the head and neck: An overview from diagnosis to genetics","volume":"11","author":"Williams","year":"2017","journal-title":"Head Neck Pathol"},{"key":"10.25259\/SNI_188_2024\/ref-18","doi-asserted-by":"crossref","first-page":"5897","DOI":"10.1038\/s41598-017-06267-z","article-title":"Risk factors for prolonged hypotension in patients with pheochromocytoma undergoing laparoscopic adrenalectomy: A single-center retrospective study","volume":"7","author":"Wu","year":"2017","journal-title":"Sci Rep"},{"key":"10.25259\/SNI_188_2024\/ref-19","doi-asserted-by":"crossref","first-page":"389","DOI":"10.4174\/jkss.2012.82.6.389","article-title":"An exclusively dopamine secreting paraganglioma in the retroperitoneum: A first clinical case in Korea","volume":"82","author":"Yi","year":"2012","journal-title":"J Korean Surg Soc"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/microsurgical-resection-of-a-giant-exclusively-dopamine-secreting-jugular-foramen-paraganglioma-a-case-report\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/microsurgical-resection-of-a-giant-exclusively-dopamine-secreting-jugular-foramen-paraganglioma-a-case-report\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T08:13:21Z","timestamp":1745568801000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/microsurgical-resection-of-a-giant-exclusively-dopamine-secreting-jugular-foramen-paraganglioma-a-case-report\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":19,"alternative-id":["10.25259\/SNI_188_2024"],"URL":"https:\/\/doi.org\/10.25259\/sni_188_2024","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"article-number":"147"}}