{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T18:12:46Z","timestamp":1769883166881,"version":"3.49.0"},"reference-count":11,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground: <\/jats:title>\nGorham-Stout disease (GSD), a fibro-lymphovascular entity in which tissue replaces the bone leading to massive osteolysis and its sequelae, rarely leads to spinal deformity\/instability and neurological deficits. Here, we report a 12-year-old female who was diagnosed and treated for GSD.<\/jats:p>\n<\/jats:sec>\n\nCase Description: <\/jats:title>\nA 12-year-old female presented with back pain, and the inability to walk, sit, or stand attributed to three MR\/CT documented L2-L4 lumbar vertebral collapses. Closed biopsies were negative. However, an open biopsy diagnosed GSD. She underwent a dorsal-lumbar-to-pelvis fusion (i.e., T5-T12 through L5\/S1\/S2) using multilevel pedicle screw\/rod stabilization and human leukocyte antigens (HLAs) matched allograft (i.e. from her father). Postoperatively, she was treated with \u201coff-label\u201d teriparatide injections, bisphosphonates, and sirolimus. Four years later, while continuing the bisphosphonate therapy, she remained stable.<\/jats:p>\n<\/jats:sec>\n\nConclusion: <\/jats:title>\nSurgical multirod stabilization from T5 to S2, supplemented with HLA compatible allograft, and multiple medical \u201coff-label\u201d therapies (i.e., teriparatide, sirolimus, and bisphosphonates) led to a good 4-year outcome in a 12-year-old female with GSD.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_221_2022","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T07:30:58Z","timestamp":1649403058000},"page":"136","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gorham-Stout disease: A multirod lumbar reconstruction with off-label suppression-remission therapy"],"prefix":"10.25259","volume":"13","author":[{"given":"Ajay","family":"Krishnan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aditya","family":"Raj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devanand","family":"Degulmadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivanand","family":"Mayi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raviranjan","family":"Rai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiv Kumar","family":"Bali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vatsal","family":"Parmar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prarthan Chirag","family":"Amin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preety","family":"Krishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirant","family":"Dave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharat","family":"Dave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2022,4,8]]},"reference":[{"key":"10.25259\/SNI_221_2022\/ref-1","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1111\/j.1651-2227.2011.02361.x","article-title":"A novel treatment approach for paediatric Gorham-Stout syndrome with chylothorax","volume":"100","author":"Brodszki","year":"2011","journal-title":"Acta Paediatr"},{"key":"10.25259\/SNI_221_2022\/ref-2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/8756-3282(90)90215-K","article-title":"An investigation of vanishing bone disease","volume":"11","author":"Dickson","year":"1990","journal-title":"Bone"},{"key":"10.25259\/SNI_221_2022\/ref-3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/BF02012113","article-title":"Gorham\u2019s disease or vanishing bone disease: Plain film, CT, and MRI findings of two cases","volume":"24","author":"Dominguez","year":"1994","journal-title":"Pediatr Radiol"},{"key":"10.25259\/SNI_221_2022\/ref-4","doi-asserted-by":"crossref","first-page":"565","DOI":"10.21037\/qims.2019.03.17","article-title":"Spinal Gorham-Stout syndrome: Radiological changes and spinal deformities","volume":"9","author":"Du","year":"2019","journal-title":"Quant Imaging Med Surg"},{"key":"10.25259\/SNI_221_2022\/ref-5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0030-4220(83)90185-8","article-title":"Perspectives on massive osteolysis: Report of a case and review of the literature","volume":"55","author":"Heffez","year":"1983","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.25259\/SNI_221_2022\/ref-6","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1016\/j.joms.2015.06.154","article-title":"Fatal progression of Gorham disease: A case report and review of the literature","volume":"73","author":"Kim","year":"2015","journal-title":"J Oral Maxillofac Surg"},{"key":"10.25259\/SNI_221_2022\/ref-7","first-page":"551","article-title":"Gorham-Stout disease in the rib and thoracic spine with spinal injury treated with radiotherapy, zoledronic acid, Vitamin D, and propranolol: A case report and literature review","volume":"11","author":"Koto","year":"2019","journal-title":"Mol Clin Oncol"},{"key":"10.25259\/SNI_221_2022\/ref-8","first-page":"956","article-title":"Cerebrospinal fluid leakage in Gorham-Stout disease due to dura mater involvement after progression of an osteolytic lesion in the thoracic spine: Case report","volume":"21","author":"Molina","year":"2014","journal-title":"J Neurosurg"},{"issue":"7","key":"10.25259\/SNI_221_2022\/ref-9","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3390\/medicina57070681","article-title":"Gorham-Stout disease with multiple bone involvement-challenging diagnosis of a rare disease and literature review","volume":"57","author":"Momanu","year":"2021","journal-title":"Medicina"},{"key":"10.25259\/SNI_221_2022\/ref-10","doi-asserted-by":"crossref","first-page":"694","DOI":"10.5312\/wjo.v5.i5.694","article-title":"Vanishing bone disease (Gorham-Stout syndrome): A review of a rare entity","volume":"5","author":"Nikolaou","year":"2014","journal-title":"World J Orthop"},{"key":"10.25259\/SNI_221_2022\/ref-11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1620\/tjem.241.249","article-title":"Successful management of Gorham-Stout disease in the cervical spine by combined conservative and surgical treatments: A case report","volume":"241","author":"Tateda","year":"2017","journal-title":"Tohoku J Exp Med"}],"container-title":["Surgical Neurology 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