{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:39:59Z","timestamp":1787971199977,"version":"build-2784847793"},"reference-count":14,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n<jats:title>Background: <\/jats:title>\n<jats:p>Paracoccidioidomycosis (PCM) is a systemic, progressive, noncontagious, and often chronic disease caused by the fungus <jats:italic>Paracoccidioides brasiliensis<\/jats:italic> that rarely affects the central nervous system (CNS). The condition is usually treated using antifungal drugs, and some cases may require surgery.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st2\">\n<jats:title>Case Description: <\/jats:title>\n<jats:p>A 55-year-old man, a smoker, without known comorbidities, was referred to the neurosurgery team with a history of a single epileptic seizure a week before hospital admission followed by progressive right- sided hemiparesis. Head computed tomography and brain magnetic resonance imaging showed an intra-axial expansive lesion affecting the left parietal lobe, associated with extensive edema and a regional compressive effect producing slight subfalcine herniation that was initially managed as an abscess. After the failure of antibiotic treatment, the patient underwent a neurosurgical procedure for excision of the lesion. Histopathological analysis revealed that it was PCM and there was no evidence of impairment of other systems due to the disease.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"st3\">\n<jats:title>Conclusion: <\/jats:title>\n<jats:p>PCM can be a serious, debilitating disease and is potentially fatal. Although isolated CNS involvement is rare, it must be considered, especially in endemic areas, as late diagnosis and treatment severely decreases good outcome rates.<\/jats:p>\n<\/jats:sec>","DOI":"10.25259\/sni_224_2020","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T05:34:33Z","timestamp":1592026473000},"page":"151","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Isolated neuroparacoccidioidomycosis as a pseudotumoral lesion in the absence of systemic disease"],"prefix":"10.25259","volume":"11","author":[{"given":"Ricardo Salemi","family":"Riechelmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Henrique","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Marques","family":"Avelar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Adolfo","family":"Xander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Henrique","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Fernando","family":"Cannoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Brasileiro","family":"de Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Carlos","family":"Veiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,6,13]]},"reference":[{"key":"10.25259\/SNI_224_2020\/ref-1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.3109\/13693786.2011.654135","article-title":"Treatment of severe forms of paracoccidioidomycosis: Is there a role for corticosteroids?","volume":"50","author":"Benard","year":"2012","journal-title":"Med Mycol"},{"key":"10.25259\/SNI_224_2020\/ref-2","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1590\/S0004-282X2000000400024","article-title":"Paracoccidioidomycosis of the central nervous system: Case report","volume":"58","author":"da Silva","year":"2000","journal-title":"Arq Neuropsiquiatr"},{"key":"10.25259\/SNI_224_2020\/ref-3","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1128\/JCM.43.9.4680-4683.2005","article-title":"Diagnosis of neuroparacoccidioidomycosis by detection of circulating antigen and antibody in cerebrospinal fluid","volume":"43","author":"da Silva","year":"2005","journal-title":"J Clin Microbiol"},{"key":"10.25259\/SNI_224_2020\/ref-4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/myc.12782","article-title":"Geographical evaluation of neuroparacoccidioidomycosis and paracoccidioidomycosis in Southern Brazil","volume":"61","author":"de Almeida","year":"2018","journal-title":"Mycoses"},{"key":"10.25259\/SNI_224_2020\/ref-5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.neurol.2017.10.015","article-title":"Neuroparacoccidioidomycosis mimicking brain tumor in an immunocompetent patient","volume":"174","author":"de Medeiros","year":"2018","journal-title":"Rev Neurol (Paris)"},{"key":"10.25259\/SNI_224_2020\/ref-6","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1016\/j.surneu.2004.09.019","article-title":"Central nervous system paracoccidioidomycosis: Diagnosis and treatment","volume":"63","author":"Elias","year":"2005","journal-title":"Surg Neurol"},{"key":"10.25259\/SNI_224_2020\/ref-7","doi-asserted-by":"crossref","first-page":"134","DOI":"10.4103\/2152-7806.140656","article-title":"Paracoccidioidomycosis simulating brain tumor","volume":"5","author":"Isolan","year":"2014","journal-title":"Surg Neurol Int"},{"key":"10.25259\/SNI_224_2020\/ref-8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4103\/2152-7806.206006","article-title":"Pseudotumoral neuroparacoccidioidomycosis of the posterior fossa: A case report and review of the literature","volume":"8","author":"Jorge","year":"2017","journal-title":"Surg Neurol Int"},{"key":"10.25259\/SNI_224_2020\/ref-9","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1055\/s-0038-1641578","article-title":"Neuroparacoccidioidomycosis: Case report and literature review","volume":"37","author":"Morais","year":"2018","journal-title":"Arq Bras Neurocir Braz Neurosurg"},{"key":"10.25259\/SNI_224_2020\/ref-10","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.wneu.2015.01.053","article-title":"Intracranial fungal granulomas: A single institutional clinicopathologic study of 66 patients and review of the literature","volume":"83","author":"Naik","year":"2015","journal-title":"World Neurosurg"},{"key":"10.25259\/SNI_224_2020\/ref-11","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.ejim.2016.04.009","article-title":"An immunocompetent 49-year-old man with a disseminated infection","volume":"34","author":"Ortiz","year":"2016","journal-title":"Eur J Intern Med"},{"key":"10.25259\/SNI_224_2020\/ref-12","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.trstmh.2006.07.006","article-title":"Neuroparacoccidioidomycosis: Analysis of 13 cases observed in an endemic area in Brazil","volume":"101","author":"Paniago","year":"2007","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.25259\/SNI_224_2020\/ref-13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11046-012-9607-y","article-title":"Neuroparacoccidioidomycosis (NPCM): Magnetic resonance imaging (MRI) findings","volume":"175","author":"Reis","year":"2013","journal-title":"Mycopathologia"},{"key":"10.25259\/SNI_224_2020\/ref-14","first-page":"277","article-title":"Central nervous system paracoccidioidomycosis: Case report and review","volume":"45","author":"Tristano","year":"2004","journal-title":"Invest Clin"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/isolated-neuroparacoccidioidomycosis-as-a-pseudotumoral-lesion-in-the-absence-of-systemic-disease\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/isolated-neuroparacoccidioidomycosis-as-a-pseudotumoral-lesion-in-the-absence-of-systemic-disease\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T05:34:39Z","timestamp":1592026479000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/isolated-neuroparacoccidioidomycosis-as-a-pseudotumoral-lesion-in-the-absence-of-systemic-disease\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,13]]},"references-count":14,"alternative-id":["10.25259\/SNI_224_2020"],"URL":"https:\/\/doi.org\/10.25259\/sni_224_2020","relation":{},"ISSN":["2152-7806"],"issn-type":[{"value":"2152-7806","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,13]]},"article-number":"151"}}