{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:56:28Z","timestamp":1787025388242,"version":"build-2736575974"},"reference-count":54,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec id=\"st1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Primary peripheral T-cell central nervous system lymphoma (PCNSL) is a rare, aggressive tumor that arises in the craniospinal axis and has an increased risk in individuals who are immunocompromised. This lesion often mimics other benign and malignant processes on radiographic imaging, leading to misdiagnosis and delays in treatment. We present a case of a patient with a history of Sj\u00f6gren\u2019s syndrome and progressive neurologic symptoms who underwent craniotomy for diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>Case Description:<\/jats:title>\n                    <jats:p>A 61-year-old woman with a history of Sj\u00f6gren\u2019s syndrome, progressive aphasia, left facial droop, and right-sided paresthesias for 4 months presented for evaluation and management. An enhancing, infiltrative lesion in the left frontal lobe with underlying vasogenic edema was appreciated and suggestive of a primary or metastatic neoplasm. The patient underwent an open biopsy for further evaluation of the lesion. Extensive histopathologic evaluation revealed a diagnosis of T-cell PCNSL. The patient was started on induction methotrexate and temozolomide followed by consolidative radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Autoimmune conditions are a risk factor for T-cell PCNSL development. T-cell PCNSL has radiographic and gross histologic features that are consistent with a broad differential, including gliomas and inflammatory processes. Prompt diagnosis and extensive histopathological evaluation is essential to ensure appropriate treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.25259\/sni_224_2021","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T10:15:07Z","timestamp":1631528107000},"page":"465","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Primary peripheral T-cell central nervous system lymphoma"],"prefix":"10.25259","volume":"12","author":[{"given":"Cylaina E.","family":"Bird","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey I.","family":"Traylor","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Caruso","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Kafka","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Rosado","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas Southwestern Medical Center, Dallas, Texas, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle M.","family":"Blackburn","sequence":"additional","affiliation":[{"name":"Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimmo J.","family":"Hatanpaa","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Texas Southwestern Medical Center, Dallas, Texas, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalil G.","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas, United States."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2021,9,13]]},"reference":[{"key":"10.25259\/SNI_224_2021\/ref-1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11912-019-0794-2","article-title":"Central nervous system involvement of natural killer and T cell neoplasms","volume":"21","author":"Aaroe","year":"2019","journal-title":"Curr Oncol Rep"},{"key":"10.25259\/SNI_224_2021\/ref-2","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1097\/RLU.0000000000002154","article-title":"Prognostic significance of interim 11C-methionine PET\/CT in primary central nervous system lymphoma","volume":"43","author":"Ahn","year":"2018","journal-title":"Clin Nucl Med"},{"key":"10.25259\/SNI_224_2021\/ref-3","doi-asserted-by":"crossref","first-page":"668","DOI":"10.3171\/jns.1991.74.4.0668","article-title":"Primary central nervous system T-cell lymphoma. 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