{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T20:13:15Z","timestamp":1769803995761,"version":"3.49.0"},"reference-count":9,"publisher":"Scientific Scholar","content-domain":{"domain":["surgicalneurologyint.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n \n Adjunctive dural sealants such as BioGlue\n \u00ae<\/jats:sup>\n are widely used to reinforce dural closure in cranial and spinal surgery. While generally effective, BioGlue\n \u00ae<\/jats:sup>\n has been associated with inflammatory foreign-body reactions that may lead to delayed mass formation and neural compression. These delayed complications can mimic the original pathology. Here, a 66-year-old male underwent primary dural closure that included the use of BioGlue, which, 6 months later, caused the delayed onset of a cauda equina syndrome.\n <\/jats:p>\n <\/jats:sec>\n \n Case Description:<\/jats:title>\n \n A 66-year-old male presented with sciatica secondary to focal L4-5 lumbar spinal canal stenosis and an intradural schwannoma at the L3 level. He underwent an L3-L5 laminectomy for resection of the tumor and decompression of the stenosis. At surgery, primary dural closure was reinforced with a muscle graft, combined with the utilization of BioGlue\n \u00ae<\/jats:sup>\n and Gel-Foam\n \u00ae<\/jats:sup>\n . Six months later, he developed a partial cauda equina syndrome attributed to an magnetic resonance imaging-documented heterogeneous extradural mass at the prior durotomy site. Surgical re-exploration allowed for resection of a newly occurring granulomatous mass at the prior operative site, comprised largely of residual BioGlue\n \u00ae<\/jats:sup>\n . Histopathology confirmed that this represented a foreign-body granulomatous reaction to the BioGlue. Postoperatively, the patient demonstrated rapid neurological improvement.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n BioGlue\n \u00ae<\/jats:sup>\n -induced granuloma represents an important delayed complication of spinal dural repair that can closely mimic recurrent pathology (i.e., in this case, stenosis and\/or tumor).\n <\/jats:p>\n <\/jats:sec>","DOI":"10.25259\/sni_22_2026","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:21:30Z","timestamp":1769761290000},"page":"60","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Delayed cauda equina compression caused by BioGlue\n \u00ae<\/sup>\n -induced granulomatous reaction following spinal dural repair: A case report"],"prefix":"10.25259","volume":"17","author":[{"given":"Hazem","family":"Alkatreeb","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Al Ahli Hospital, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila Tarek Abbas","family":"Metwaly","sequence":"additional","affiliation":[{"name":"Independent, New York, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El Fatih Bashir","family":"El Malik","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Al Ahli Hospital, Doha, Qatar"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"10.25259\/SNI_22_2026\/ref-1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/WNQ.0b013e31820016d3","article-title":"Acute mass formation of bioglue after spinal dural repair","volume":"20","author":"Abuzayed","year":"2010","journal-title":"Neurosurg Q"},{"key":"10.25259\/SNI_22_2026\/ref-2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0967-5868(02)00262-X","article-title":"Reconstruction of the sellar floor using Bioglue following transsphenoidal procedures","volume":"10","author":"Kumar","year":"2003","journal-title":"J Clin Neurosci"},{"key":"10.25259\/SNI_22_2026\/ref-3","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0967-5868(03)00163-2","article-title":"Evaluation of the use of BioGlue in neurosurgical procedures","volume":"10","author":"Kumar","year":"2003","journal-title":"J Clin Neurosci"},{"key":"10.25259\/SNI_22_2026\/ref-4","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.spinee.2014.09.012","article-title":"Delayed cauda equina compression after spinal dura repair with BioGlue: Magnetic resonance imaging and computed tomography aspects of two cases of \u201cglue-oma\u201d","volume":"15","author":"Lauvin","year":"2015","journal-title":"Spine J"},{"key":"10.25259\/SNI_22_2026\/ref-5","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1007\/s00586-013-3138-1","article-title":"The use of surgical sealants in the repair of dural tears during non-instrumented spinal surgery","volume":"23","author":"Miscusi","year":"2014","journal-title":"Eur Spine J"},{"key":"10.25259\/SNI_22_2026\/ref-6","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00701-017-3411-x","article-title":"BioGlue\u00ae induced granuloma causing symptomatic spinal cord compression: A late complication","volume":"160","author":"Rasul","year":"2018","journal-title":"Acta Neurochir (Wein)"},{"key":"10.25259\/SNI_22_2026\/ref-7","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.jocn.2004.03.018","article-title":"The biocompatibility of BioGlue with the cerebral cortex: A pilot study","volume":"11","author":"Stylli","year":"2004","journal-title":"J Clin Neurosci"},{"key":"10.25259\/SNI_22_2026\/ref-8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.spinee.2012.01.017","article-title":"Dural repairs with spinal sealants","volume":"12","author":"Woo","year":"2012","journal-title":"Spine J"},{"key":"10.25259\/SNI_22_2026\/ref-9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jocn.2004.06.006","article-title":"Persistence of Bioglue in spinal dural repair","volume":"12","author":"Yuen","year":"2005","journal-title":"J Clin Neurosci"}],"container-title":["Surgical Neurology International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/surgicalneurologyint.com\/delayed-cauda-equina-compression-caused-by-bioglue-induced-granulomatous-reaction-following-spinal-dural-repair-a-case-report\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/delayed-cauda-equina-compression-caused-by-bioglue-induced-granulomatous-reaction-following-spinal-dural-repair-a-case-report\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T08:21:31Z","timestamp":1769761291000},"score":1,"resource":{"primary":{"URL":"http:\/\/surgicalneurologyint.com\/surgicalint-articles\/delayed-cauda-equina-compression-caused-by-bioglue-induced-granulomatous-reaction-following-spinal-dural-repair-a-case-report\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,30]]},"references-count":9,"alternative-id":["10.25259\/SNI_22_2026"],"URL":"https:\/\/doi.org\/10.25259\/sni_22_2026","relation":{},"ISSN":["2152-7806","2229-5097"],"issn-type":[{"value":"2152-7806","type":"electronic"},{"value":"2229-5097","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,30]]},"article-number":"60"}}